Canine Hepatic Neoplasms: A Clinicopathologic Study

Abstract

Abstract. One hundred ten primary hepatic neoplasms, excluding hematopoietic and vascular tumors, were diagnosed in 12,245 canine necropsies. Included were 55 hepatocellular carcinomas, 24 bile duct carcinomas, 2 combined hepatocellular and cholangiocarcinomas, 15 carcinoids and 14 sarcomas. A majority of the dogs with hepatocellular carcinoma (80%), bile duct carcinoma (65%) and sarcoma (61%) were 10 years old or older; 71% of the dogs with carcinoid were under 10 years old. Hepatocellular carcinoma and sarcoma occurred more often in males, bile duct carcinoma in females, and no sex predisposition was found in dogs with carcinoid. All dogs had hematologic and biochemical abnormalities relating to liver function. The aspartate amino transferase/alanine amino transferase ratio was less than one in cases of hepatocellular carcinoma and bile duct carcinoma, and more than one in cases of carcinoid and sarcoma. A massive lesion in one of the liver lobes was the most common gross morphologic feature in cases of hepatocellular carcinoma and bile duct carcinoma, with the left lateral lobe affected most often. In cases of carcinoid, most of the lesions were diffuse. The most common sites of metastases were lymph nodes and lungs for hepatocellular carcinoma and bile duct carcinoma, lymph nodes and peritoneum for carcinoid, and spleen for sarcoma.Neoplasms of the liver and biliary tracts are uncommon in domestic animals [3,6,15,16,22,23,26,31, 361. Frequency in the dog vanes from 0.6% to 1.3% of all neoplasms [6,9,15,16,18,31,33]. Only a few studies deal with the clinicopathologic features of a large number of canine primary hepatic neoplasms [4, 12,14,15,28,31,331. Materials and MethodsCase records and histologic specimens from dogs with hepatic neoplasms seen between 1962 and 1977 at The Animal Medical Center were reviewed. AU cases with enough slides to confirm the diagnosis were included in the study. Details of the 110 dogs' clinical and gross pathologic fmdings were collected from the medical and necropsy records. Because neoplasms arising from the hematopoietic and vascular systems usually involve several organs, they were excluded from this study. Hepatocellular adenoma, intrahepatic bile duct adenoma and bile duct cyst adenoma also were excluded because of their high frequency and because of the difficulty in distinguishing between nodular hyperplasia and hepatocellular adenoma.The hepatic neoplasms were grouped under hepatocellular carcinoma, bile duct carcinoma, 553

Transitional carcinoma with extensive invasion of the bony orbit in a dog

“…Transitional carcinoma of the respiratory epithelium is infrequently reported in dogs (Patnaik, 1989;Wilson and Dungeword, 2002;Lopez, 2007). The term transitional carcinoma is recommended by the World Health Organization for this kind of tumor in dogs (Dungworth et al, 1999), despite sometimes being reported as respiratory epithelial carcinoma, non-keratinizing squamous cell tumor or undifferentiated carcinoma (Dungworth et al, 1999;Wilson and Dungword, 2002;Caswell and Williams, 2007).…”

Diabetes Mellitus after Resection of Hepatocellular Carcinoma with Hypoglycemia in a Dog

“…Sci. 68 (7): [765][766][767] 2006 Hepatocellular carcinoma (HCC), the most common primary liver tumor in dogs [7,8], has previously been reported to be associated with hypoglycemia as paraneoplastic syndrome in a dog [6]. In general, hypoglycemia of non-islet cell tumors such as HCC is improved by resection and reappears after recurrence of a tumor [6].…”

“…In these non-islet cell tumors, the serum insulin concentration is low in dogs [1,3,8,10]. Hypoglycemia is detected in these tumors, which are generally very large and found in the abdominal cavity.…”

"Utilização da ultra-sonografia em cães com suspeitas de neoplasias do sistema digestório (fígado, intestinos e pâncreas)"

“…Alguns desses agentes químicos seriam os peptídios e as citocinas (FOLKMAN et al, 1971). A angiogênese normal ocorre durante o desenvolvimento embrionário e na vida adulta normal, durante a ovulação e a cicatrização de feridas (CERRI; MÓLNAR; VEZOZZO, 1998 PAITNAIK et al, 1980;STRAW, 1996). O exame ultra-sonográfico é uma técnica extremamente útil na avaliação hepática quando da suspeita de neoplasias primárias ou metastáticas (WHITELEY et al, 1989).…”

“…O tumor benigno dos hepatócitos é denominado adenoma hepatocelular (ou hepatoma), enquanto o tumor maligno epitelial é denominado carcinoma hepatocelular. O carcinoma hepatocelular é a neoplasia maligna primária hepática mais comum em cães (HAMMER; SIKKEMA, 1995;PAITNAIK et al, 1980;STRAW, 1996). Em relação às neoplasias linfóides que acometem o fígado, o linfoma é predominante em animais da espécie felina e, embora se acredite que a mesma prevalência ocorra em cães, nem sempre o parênquima hepático de cães com linfoma é biopsiado (HAMMER; SIKKEMA, 1995).…”