Canine gastrointestinal tract tumours: a restrospective study of 74 cases

Abstract

The aim of our study was to investigate histopathologically the incidence of gastrointestinal tract tumours in dogs in the Czech Republic in relation to their age, sex and breed. In total, 29 gastric and 45 intestinal tumours from 3827 gastrointestinal tract biopsies were investigated. The average age of dogs with gastric lymphoma, adenocarcinoma, and other mesenchymal tumours was 7.3 years, 9.5 years, and > 10 years, respectively. Breed predisposition to adenocarcinoma was evidenced in the Belgian Shepherd and Leonberger, to lymphoma in the Doberman (P < 0.01). The most frequent site of adenocarcinoma was antrum pyloricum (66.7%); lymphomas involved gastric wall diffusely. The average age of dogs with intestinal adenoma, adenocarcinoma, lymphoma, leiomyoma or leiomyosarcoma and carcinoid was 7.5, 8.5, 8.5, 12, and 14 years, respectively. The age predisposition to intestinal adenoma and lymphoma was 7-8 years (P < 0.01) and to adenocarcinoma 7-8 years (P < 0.05); mesenchymal tumours occurred at the age of 11-12 years (P < 0.01). Breed predisposition to intestinal adenoma was evidenced in the Pug, Leonberger and English Setter (P < 0.01), to adenocarcinoma in the English Setter (P < 0.01) and Hovawart (P < 0.05), to lymphoma in the Doberman and Hovawart (P < 0.05). The most frequent site of occurrence of intestinal tumours was the colorectal region. The study revealing breed, sex and age predisposition to gastrointestinal tumours in dogs has not been described yet in the literature.

A histopathological study on spontaneous gastrointestinal epithelial tumors in dogs

“…2E) The present study, we reviewed 131 canine gastrointestinal epithelial tumors. While, information on the average age, location of tumor lesions, or predisposition towards a particular gender is already well-established [15][16][17] , the present study revealed that in Japan, gastrointestinal epithelial tumors occur more frequently in Jack Russell Terriers and Miniature Dachshunds. Previous reports on the subject revealed diverse results, with some authors stating that there was no predisposition towards any particular breed, in canine gastric neoplasms 15,18 , whereas others showed that Belgian Shepherd Dogs 19 , Collies 15 , German Shepherds 15,20 and West Highland White terriers 20 have increased risks of gastric or intestinal carcinoma.…”

Intestinal mucinous adenocarcinoma with metastases to epididymis, testis and tunica albuginea in a dog

“…Adenocarcinoma is one of the most common intestinal neoplasms in dogs, and comprises 20% to 53% of intestinal tumors, and 37 to 55% of intestinal malignancies (14,27). It carries a poor prognosis, and due to lack of specific clinical signs and late diagnosis, evidence of nodal or angiolymphatic invasion is noted in 52% and visceral metastases in 38% of cases at the time of diagnosis (25).…”

“…Intestinal adenocarcinoma is one of the most common malignant tumors in canine gastrointestinal tract, together with lymphoma and sarcomas (leiomyosarcomas and gastrointestinal stromal tumors) (14,27). It presents generally with a high level of intestinal wall infiltration at the time of diagnosis, often with lymph node metastases, rendering a poor prognosis to the condition (25).…”

Remarkably long overall survival of a 15‐month‐old Australian shepherd dog with gastric T‐cell lymphoma

“…While most alimentary lymphomas are restricted to the gastrointestinal tract, one-third occur concomitantly with the multicentric form (Couto and others 1989, Rassnick and others 2009). Median age of affected dogs ranges between 8.2 and 10 years (Frank and others 2007, Rassnick and others 2009, Frgelecova and others 2013). …”