Candida Markers of Urogenital Biotopes Diseases: Reactivity to Lectins of Probiotics

Lakhtin, M. V.; Lakhtin, V. M.; Afanasiev, S. S.; Bayrakova, A. L.; Алешкин, В. А.; Afanasiev, M. S.

doi:10.29413/abs.2018-3.1.7

Cited by 5 publications

(4 citation statements)

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“…• • Synergism between aLL and LB in antistaphylococcal actions LSSM possess potential of diagnostics and prognostics of biotope diseases [37]. Results support important principle approach that diseases of MB (as in the case of CBF according to the principle "there is the body-there are diseases") reflect own "biotope diseases" in organism [39].…”

Section: Anticandidosis Activitiesmentioning

confidence: 61%

“…According to the multifunctional potential of artificial GC used, resulting events in biotope can be the following ones: antipathogenic actions (the use of GC-imitating pathogenic cell surface structures), prebiotic and symbiotic (synbiotic) actions (the use of GC-imitating prebiotic structures), increasing own human organism protective systems (the use of GC-interacting and GC-regulating macrophages and macrophage-like lymphocytes through their systemic receptor lectins), antitumor actions (potential using antigenic GC together with LSSM as antagonists and synergists in intercellular antitumor and anti-infectious communications [37]), and cytokine lectin/lectin-like cascades initiated/regulated with LSSM potentially influencing redistribution of cytokine network in organism.…”

Section: Membrane Technological Prospects Of Lssmmentioning

confidence: 99%

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Metabolite Multiprobiotic Formulas for Microbial Health

Lakhtin¹,

Lakhtin²,

Алешкин³

et al. 2019

Oral Health by Using Probiotic Products

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On example of Lactobacillus and Bifidobacterium strains, approaches in creation of human multistrain probiotic metabolite mixtures for different goals were proposed. Human probiotic lectin systems (LS) (mucosal, others) reveal functions needed for organism. Advanced features of such systems include capability to recognize synthetic polymeric polyvalent glycoconjugates (GC)-imitators of natural ones (modified polysaccharides, glycoantigens of medical significance). Probiotic lectin systems function as imitators of multipro-/sym-/synbiotics in their resulting actions. They serve as carriers of the biotope glycoconjugate décor including glycoprebiotics, glycometabiotics, glycodrugs, and agents supporting décor organization and resistance. Probiotic lectin systems represent new perspective system agents to improve the health of mucosal microbiocenoses (MB) organized as communicative bodies to be corrected according to the principle "there is bodythere are diseases." They act as metabolomebiotics according to the principle "the network in the network." They deepen biotope resistance allowing quicker return to balance. They support prophylactic and therapeutic procedures directed to prolong aging and improve quality of life. Multistrain metabolite constructions can predict perspective cellular formulas of multipro-/synbiotics for prophylaxis, supporting and accompanying therapy. Approaches developed are universal. They are useful in the study of any Gram-positive and eukaryotic (yeasts and yeast-like fungi) monoand mixed cultures. The methodological principles proposed and described are of value for extended fields of clinical microbiology and medical bio-/nanotechnology.

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Section: Anticandidosis Activitiesmentioning

confidence: 61%

Section: Membrane Technological Prospects Of Lssmmentioning

confidence: 99%

Metabolite Multiprobiotic Formulas for Microbial Health

Lakhtin¹,

Lakhtin²,

Алешкин³

et al. 2019

Oral Health by Using Probiotic Products

View full text Add to dashboard Cite

show abstract

“…*PB in connection with diseases of growth disorders, the use of antibiotics (PB in weight control of industrial animals, instead of subdoses of antibiotics, against antibiotic-induced diseases); substitution of antibiotics for PB as promoters of animal weight; the use of PB to solve the problem of obesity of individuals [15,25,[37][38][39]). *New PB system groups: Probiotic lectins recognizing GC as conversion sources of the potential therapeutic PB [14,22,[40][41][42].…”

Section: Areas Of Pb Researchmentioning

confidence: 99%

Postbiotics as Factors Against Diseases Along Metabolic Axes

Lakhtin

Melikhova

et al. 2022

ASJ

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The review represents an analysis of recent year publications in connection with preventive and therapeutic use of postbiotics (PB). Postbiotics are widely used as immunomodulators, anti-inflammatory agents, protectors and the normalizers of metabolism of the open cavity mucosal biotopes, liver, brain and other organs, tissues and innate immunity cell populations that co-function to intestinal microbial metabolites as a network (cofunction within a number of metabolic axes “intestine-other locations”). They act in combination with other effectors as auxiliary agents prolonging the effect of drugs and supporting them. Prophylactic and therapeutic uses of PB are directed against groups of intestinal infection diseases, hepatitis, tumors, neurodegenerative brain disorders, other metabolic disorders and pathologies. New aspects of research of PB include the study and application of recognizing and binding therapeutic PB according to and in connection with a network of “Probiotic lectins—Glycoconjugates” interactions. The data indicate the prospects of a search and application of the new groups and combinations of PB directed at glycoconjugate exposed targets in accompanying and supportive therapy. Probiotic bifidobacteria, lactobacilli, baker’s yeast and probiotic lectins are perspective resources of synergistic sets of metabolite-cellular PB against diseases, pathologies and groups of infections.

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“…Lectins are related to protein/ (oligo) peptide molecules and their complexes which are capable to recognize and reversibly bind carbohydrates and carbohydrate moiety of glycoconjugates (GC). Lectins of the cultural probiotic strains of lactobacilli and bifidobacteria (from the healthy adult donor intestines) were isolated and characterized by us [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][21][22][23][24][25]. Probiotic lectins studied were from the Russian multi-strain lactobacillar probiotic -Acilact (its properties as the sum of three ingredient strains) and bifidobacterial mixture of consortium type [1,2,5,7,19].…”

Section: Introductionmentioning

confidence: 99%

Antimycotic systems of bifidobacteria

Lakhtin¹,

Lakhtin²,

Davydkin³

et al. 2021

World J. Adv. Res. Rev.

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Based on own data, the basis positions concerning probiotic bifidobacteria as producers of adaptable and controlled network of functionally coupled antimycotics of the recognition type (lectin and lectin-like type) were described. Such antimycotics act as an organized ordered system of metabolomebiotics which are distinct from the classical antibiotics, acting with other (expanded) mechanisms resulting in increase of resistance of the organism protective network. Bifidobacterial antimycotics are represented by probiotc lectin and postbiotic systems of promised prophylactic and therapeutic significance in future.

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Candida Markers of Urogenital Biotopes Diseases: Reactivity to Lectins of Probiotics

Cited by 5 publications

References 0 publications

Metabolite Multiprobiotic Formulas for Microbial Health

Metabolite Multiprobiotic Formulas for Microbial Health

Postbiotics as Factors Against Diseases Along Metabolic Axes

Antimycotic systems of bifidobacteria

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