New aspects of human mucosal cavity protection systems are under consideration. On the basis of own data it was suggested that mucosal cavities function as mucosal organs. New players of mucosal organ were proposed. They included system probiotic lectins and probiotic microorganisms, and system synthetic polymeric multivalence pattern glycoconjugates. Lectins and glycoconjugates (mucin-like or imitating, antigens, polysaccharides and other high molecular mass metabolites and postbiotics) were suggested to communicate to other glycoconjugates-recognizing molecules and receptors of the human higher hierarchic protection systems.
Concept of functioning mucosal organs is supported by own proposals, strategies, approaches, methods and algorithms. The data are useful for constructing biotope ordered pro/synbiotic microbiocenoses for application in medical biotechnology.
The main dominated factors and strategies of non-antibody immunity (the human innate and others, microbial probiotic) aimed at maintaining and strengthening health in connection with the pandemic disease COVID-19 are considered and currently systematized. An integrated current evaluation of the non-antibody immunity is given and preventive and therapeutic approaches to its use for combating diseases accompanying COVID-19 (or on the it’s background) are indicated. Innate immunity is considered as the basic and deep support for the antibody level immunity as the higher and super-structure. The concept of increasing sensitivity to be infected with COVID-19 in population groups depending on the presence and/or the progress of spectrum pathologies and diseases and in connection with the waves of the pandemic COVID-19 is proposed.
Examples of the nomenclature enzymes of all known classes with intrinsic lectin properties are represented, described and ordered. Such bi/multifunctional enzymes (enzybiotics) act as communicative agents, possess independent carbohydrate binding motifs, domains, epitopes or modules within subunit/molecule or supra-molecular assembly (free or solid-phased). Lectin part serve as modulator, switch and/or navigator of the whole resulting pattern enzyme (involving both catalytic center and lectinic sites) specificities toward targets. These enzybiotics (native and recombinant) as well as lectinbiotics (lectin-biotics) with intrinsic enzyme activities and high communicative potential possess promising broad prospects in food industry, medical biotechnology, prophylaxis and therapy. Among examples there are probiotic lectin enzybiotics (mainly from bifidobacteria and lactobacilli) that can serve perspective metabolite postbiotic systems for support or correction of the healthy individual or the patient mucosal open cavity biotope pathological status, respectively. Lectin-enzyme relationships improve platform for constructing advanced autoregulated systems influencing interactome at all levels of the organism. They support a lot of possible innovations in industrial biotechnology and medicine.
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