Candida esophagitis: species distribution and risk factors for infection

Kliemann, Dimas Alexandre; Pasqualotto, Alessandro C.; Falavigna, Maicon; Giaretta, Thiane; Severo, Luiz Carlos

doi:10.1590/s0036-46652008000500002

Cited by 47 publications

(42 citation statements)

References 21 publications

(21 reference statements)

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“…An increase in the percentage of colonized people has been observed according to their age and the presence of predisposing local or general factors (1,2). The first stage of the infection includes adhesion to cellular surfaces.…”

Section: Introductionmentioning

confidence: 99%

Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans

Se¹,

Ma²,

Barembaum³

et al. 2011

Med Oral

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Objective: The aim of this work was to assess the antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on virulence factors of Candida albicans. Study Design: Ten isolated strains of Candida albicans obtained from 10 patients with oral candidiasis and a collection strain of C. albicans were treated with antifungal agents in different concentrations or combinations of them. Virulence factors analyzed were the cell surface hydrophobicity, the germinative tube development, the phospholipase activity and the post-antifungal effect of that exposure. Results: Virulence factors of the isolated strains obtained from patients together with the collection strain showed significant decreases with the different antifungal treatments, except for hydrophobicity and phospholipase activity. The development of germinative tube was the most sensitive factor to all the antifungal agents used. Untreated strains as well as the ones treated with antifungal agents showed a positive correlation among the virulence factors analyzed. No synergic effects arose from the combinations of the used drugs. Conclusions: C. albicans isolated strains from patients showed high phospholipase activity and germinative tube production, which corroborates their capacity to infect the oral mucosa and the high prevalence of species. As a whole, our results imply that short exposures to sub-inhibitory concentrations of the antifungal agents under analysis, isolated or combined, can modulate the way virulence factors get manifested, thus decreasing their pathogenicity.

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Section: Introductionmentioning

confidence: 99%

Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans

Se¹,

Ma²,

Barembaum³

et al. 2011

Med Oral

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show abstract

“…Candidiasis of the gastrointestinal system mostly affects the esophagus and the infection is seen as patch plaques on the mucosa [12] . Although a typical fungal infection was not detected in the esophagus of our patient, such contamination can not be excluded and may have occurred during endoscopic intervention, i.e.…”

Section: Discussionmentioning

confidence: 99%

A case of asymptomatic fungal and bacterial colonization ofan intragastric balloon

Coşkun¹,

Bozkurt²

2009

WJG

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Intragastric balloon therapy, as a part of a multidisciplinary weight management program, is an effective short-term intervention for weight loss. Although the insertion procedure is easy and generally well tolerated by patients, a few complications can occur. We report here a heavy smoker with intragastric balloon insertion complicated by colonization with opportunistic organisms. The 27-year-old female, body mass index 35.5 kg/m 2 , had a BioEnterics ® Intragastric Balloon inserted under conscious sedation without any perioperative complications. Six months later, when the standard removal time arrived, the balloon was seen to be covered with a necrotic white-gray material. Microbiological examination revealed Enterobacter cloacae and Candida species yeast colonies. We recommend that asymptomatic fungal and/or bacterial colonization should be considered among the complications of the intragastric balloon procedure, despite its rarity.

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“…Der häufigste Erreger einer Pilzinfektion des Ösophagus ist Candida albicans, seltenere Vertreter sind Candida tropicalis und Candida parapsylosis [20,21] [24].…”

Section: Candida-ösophagitisunclassified

Differentialdiagnose Ösophagitis: Eosinophile Ösophagitis, Candida, Cytomegalievirus

Miehlke¹

2011

Viszeralmedizin

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Nach der Refluxösophagitis sind die eosinophile Ösophagitis und die infektiösen Ösophagitiden, allen voran die Candida- und die Cytomegalievirus(CMV)-Ösophagitis, häufige Ursache entzündlicher Veränderungen der Speiseröhre. Insbesondere die eosinophile Ösophagitis stellt eine wichtige und zunehmend häufiger diagnostizierte Differentialdiagnose dar. Die sichere Abgrenzung der eosinophilen Ösophagitis von der gastroösophagealen Refluxkrankheit (GERD) kann zuweilen schwierig sein, da auch die GERD zu einer vermehrten Eosinophilie der Ösophagusschleimhaut führen und das Symptomspektrum dieser beiden Entitäten überlappen kann. Die Candida-Ösophagitis kann gelegentlich ein ähnliches endoskopisches Bild wie eine eosinophile Ösophagitis bieten und stellt daher eine wichtige Differentialdiagnose dar. Die CMV-Ösophagitis kommt praktisch nur bei immunkompromittierten Patienten vor. Die Symptomatik kann der einer Candida-Ösophagitis ähneln. Die sichere Differenzierung gelingt nur durch den endoskopisch-bioptischen Befund.

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Candida esophagitis: species distribution and risk factors for infection

Cited by 47 publications

References 21 publications

Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans

Antifungal and post-antifungal effects of chlorhexidine, fluconazole, chitosan and its combinations on Candida albicans

A case of asymptomatic fungal and bacterial colonization ofan intragastric balloon

Differentialdiagnose Ösophagitis: Eosinophile Ösophagitis, Candida, Cytomegalievirus

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