Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*

Kett, Daniel H.; Azoulay, Élie; Echeverria, Pablo; Vincent, Jean‐Louis

doi:10.1097/ccm.0b013e318206c1ca

Cited by 347 publications

(302 citation statements)

References 42 publications

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“…Approximately 80% of IFIs are due to Candida species. In a worldwide ICU prevalence study, Candida was the third most frequently isolated microorganism accounting for 17% of all infections [7,8]. The rank order of Candida in bloodstream infections varies by country and is influenced by the type of patients studied.…”

Section: Invasive Candidiasismentioning

confidence: 99%

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

et al. 2017

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Purpose:To describe concisely the current standards of care, major recent advances, common beliefs that have been contradicted by recent trials, areas of uncertainty, and clinical studies that need to be performed over the next decade and their expected outcomes with regard to Candida and Aspergillus infections in non-neutropenic patients in the ICU setting. Methods:A systematic review of the medical literature taking account of national and international guidelines and expert opinion. Results:Severe invasive fungal infections (IFIs) are becoming increasingly frequent in critically ill patients. Approximately 80% of IFIs are due to Candida spp. and 0.3-19% to Aspergillus spp. Recent observations emphasize the necessity of building a worldwide sentinel network to monitor the emergence of new fungal species and changes in susceptibility. Robust data on the attributable mortality are essential for the design of clinical studies with mortality endpoints. Although early antifungal therapy for Candida has been recommended in patients with risk factors, sepsis of unknown cause, and positive Candida serum biomarkers [β-1 → 3-d-glucan (BDG) and Candida albicans germ tube antibody (CAGTA)], its usefulness and influence on outcome need to be confirmed. Future studies may specifically address the optimal diagnostic and therapeutic strategies for patients with abdominal candidiasis. Better knowledge of the pharmacokinetics of antifungal molecules and tissue penetration is a key issue for intensivists. Regarding invasive aspergillosis, further investigation is needed to determine its incidence in the ICU, its relationship with influenza outbreaks, the clinical impact of rapid diagnosis, and the significance of combination treatment. Conclusions:Fundamental questions regarding IFI have to be addressed over the next decade. The clinical studies described in this research agenda should provide a template and set priorities for the clinical investigations that need to be performed.

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Section: Invasive Candidiasismentioning

confidence: 99%

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

et al. 2017

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“…Candida spp. is a normal commensal of the skin and gastrointestinal and genitourinary tracts, and Candida albicans is the most frequent species isolated from clinical specimens (Kett et al, 2011;Enoch et al, 2006). Among the Candida species, C. albicans is associated with bloodstream infections in 44% of cases in Latin America and 62% in Europe (Richardson & Lass-Flörl, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-Candida albicanseffectiveness of citral and investigation of mode of action

Lima

Nóbrega

Oliveira

et al. 2012

Pharmaceutical Biology

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“…are a leading cause of bloodstream infection (BSI), associated with high mortality and increased hospital costs [1]. The annual incidence of Candida BSI varies greatly by region based on epidemiological studies from Blood samples were collected and processed using either the Bactec™ 9120 (Beckton Dickinson) or BacT/ALERT ® 3D (BioMérieux) automated blood culture systems.…”

Section: Introductionmentioning

confidence: 99%

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

Pongrácz

Juhász

Iván

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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The incidence of Candida bloodstream infection (BSI) has increased during the past decades. Species distribution is changing worldwide, and non-albicans Candida spp. are becoming more prevalent. Acquired resistance to antifungal agents has been documented in several reports. The aim of our study was to assess the epidemiology and antifungal susceptibility of Candida isolates from BSI at our institute. The incidence of Candida BSI increased during the fi rst four years of our investigation, from 1.7 to 3.5 episodes / 10 000 admissions, then dropped to 2.66 episodes / 10 000 admissions in the last year. The most frequently isolated species was C. albicans (63%), followed by C. glabrata (13%), C. parapsilosis (10.2%), C. tropicalis (9.3%), and C. krusei (3.7%). One isolate each of C. kefyr, C. fabianii and C. inconspicua were detected. The percentage of C. albicans remained stable throughout the study period. The most frequent risk factors of Candida BSI in our patient population were intensive care treatment (60.4%), abdominal surgery (52.5%), and solid malignancy (30.7%). All isolates were wild-type organisms, no acquired antifungal resistance was detected.

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Candida bloodstream infections in intensive care units: Analysis of the extended prevalence of infection in intensive care unit study*

Cited by 347 publications

References 42 publications

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

Intensive care medicine research agenda on invasive fungal infection in critically ill patients

Anti-Candida albicanseffectiveness of citral and investigation of mode of action

Significance of yeasts in bloodstream infection: Epidemiology and predisposing factors of Candidaemia in adult patients at a university hospital (2010–2014)

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