Cancer treatment and survivorship statistics, 2014

Abstract

The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment. In order for the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborated to estimate the number of current and future cancer survivors using data from the Surveillance, Epidemiology, and End Results (SEER) program registries. In addition, current treatment patterns for the most common cancer types are described based on information in the National Cancer Data Base and the SEER and SEER-Medicare linked databases; treatment-related side effects are also briefly described. Nearly 14.5 million Americans with a history of cancer were alive on January 1, 2014; by January 1, 2024, that number will increase to nearly 19 million. The 3 most common prevalent cancers among males are prostate cancer (43%), colorectal cancer (9%), and melanoma (8%), and those among females are cancers of the breast (41%), uterine corpus (8%), and colon and rectum (8%). The age distribution of survivors varies substantially by cancer type. For example, the majority of prostate cancer survivors (62%) are aged 70 years or older, whereas less than one-third (32%) of melanoma survivors are in this older age group. It is important for clinicians to understand the unique medical and psychosocial needs of cancer survivors and to proactively assess and manage these issues. There are a growing number of resources that can assist patients, caregivers, and health care providers in navigating the various phases of cancer survivorship.

Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity

“…41,42 In addition, melanomas are exceptionally resistant to chemotherapy treatment and have a high incidence of relapse. [43][44][45][46][47] Our previous 8 and current studies have revealed a prominent role of deregulated guanylate pools in melanoma progression. Altered expression of enzymes involved in guanylates biosynthesis priming the cells toward an increase in guanylates production occurs already in primary melanomas (GMPR) and peaks at the metastatic stage (IMPDH2, GMPR, and GMPS) (Wawrzyniak et al 8 and Figure 3 and Supplementary Figure S2).…”

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

“…Surgical resection of a tumor is the preferred option, especially at early stages of disease 3. However, surgery is often not possible for several reasons, including the type, location, stage of cancer, and underlying diseases.…”

Qualidade de vida relacionada à saúde de idosos em tratamento quimioterápico

“…2 Dentre as formas de tratamento das neoplasias, a quimioterapia é a mais frequente, e até 70% dos tumores necessitarão de tratamento quimioterápico em algum momento do curso da doença. 3 A avaliação da qualidade de vida (QV) de pacientes em tratamento quimioterápico possibilita melhor compreensão da intensidade e quantidade dos sintomas do paciente e da importância que isso tem na sua saúde, permitindo também melhorar o planejamento da estratégia terapêutica. 3 A QV é uma noção eminentemente humana, que tem sido correlacionada ao grau de satisfação encontrado na vida familiar, amorosa, social e ambiental, e à própria estética existencial.…”

“…3 A avaliação da qualidade de vida (QV) de pacientes em tratamento quimioterápico possibilita melhor compreensão da intensidade e quantidade dos sintomas do paciente e da importância que isso tem na sua saúde, permitindo também melhorar o planejamento da estratégia terapêutica. 3 A QV é uma noção eminentemente humana, que tem sido correlacionada ao grau de satisfação encontrado na vida familiar, amorosa, social e ambiental, e à própria estética existencial. 4 Na área de saúde, o conceito mais utilizado tem sido o de "qualidade de vida relacionada à saúde" (QVRS) que carece de definição única.…”