Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Luo, Dandan; Carter, Kevin A.; Miranda, Dyego; Lovell, Jonathan F.

doi:10.1002/advs.201600106

Cited by 352 publications

(269 citation statements)

References 231 publications

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“…Chemophototherapy, the combination of chemotherapy and phototherapy, is an emerging approach for tumor treatment and more effective than monotherapy. [15] The NIR light-induced cytotoxicity of DOX-loaded yolk-shell Fe 3 O 4 @Au NPs was further assessed by methyl thiazolyl tetrazolium (MTT) assay. As can be seen in Figure 3e, the viability of U87MG human glioma cells treated with DOX-loaded yolkshell Fe 3 O 4 @Au NPs plus NIR irradiation was significantly lower than that of cells treated with yolk-shell Fe 3 O 4 @Au NPs plus NIR irradiation or free DOX alone, which could be ascribed to the synergistic effect of chemotherapy and photothermal therapy ( Figure S11, Supporting Information).…”

Section: Doi: 101002/adma201606681mentioning

confidence: 99%

Yolk–Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic–Plasmonic Hybrid Theranostic Platform

et al. 2017

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Magnetic-plasmonic hybrid nanoparticles (MPHNs) have attracted great interest in cancer theranostics. However, the relaxivity of the magnetic component is typically reduced by the plasmonic component in conventional core-shell structured MPHNs, due to the presence of a water-impenetrable coating which severely restricts the proximity of protons to the magnetic portion. To circumvent this issue, yolk-shell structured MPHNs comprising a Fe O core within a hollow cavity encircled by a porous Au outer shell are designed. As expected, the introduction of hollow cavity between the magnetic and plasmonic portions significantly prevents the decline in relaxivity of the Fe O core caused by the Au layer. Moreover, in addition to conferring high near-infrared absorption to plasmonic component, the hollow cavity and the pores in the outer shell can also provide a large storage space and release channels for anticancer drugs. Furthermore, the multicomponent nanoparticles (NPs) still have a compact size of less than 100 nm to ensure efficient tumor accumulation. Taken together, the yolk-shell Fe O @Au NPs can be regarded as an ideal magnetic-plasmonic theranostic platform for magnetic resonance/photoacoustic/positron emission tomography multimodal imaging and light-activated chemothermal synergistic therapy.

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Section: Doi: 101002/adma201606681mentioning

confidence: 99%

Yolk–Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic–Plasmonic Hybrid Theranostic Platform

et al. 2017

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“…Upon RFRT mediated PDT, endothelial gaps increased resulting in superior vascular permeability and massive nanoparticle accumulation[48, 49]. Given that PLZ4 also interacts with integrin αvβ3, it would be interesting to explore the potential similar vascular effects through PLZ4-tumor endothelial cell interaction.…”

Section: Discussionmentioning

confidence: 99%

Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer

Lin

Liu

et al. 2016

Biomaterials

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The overall prognosis of bladder cancer has not been improved over the last 30 years and therefore, there is a great medical need to develop novel diagnosis and therapy approaches for bladder cancer. We developed a multifunctional nanoporphyrin platform that was coated with a bladder cancer-specific ligand named PLZ4. PLZ4-nanoporphyrin (PNP) integrates photodynamic diagnosis, image-guided photodynamic therapy, photothermal therapy and targeted chemotherapy in a single procedure. PNPs are spherical, relatively small (around 23 nm), and have the ability to preferably emit fluorescence/heat/reactive oxygen species upon illumination with near infrared light. Doxorubicin (DOX) loaded PNPs possess slower drug release and dramatically longer systemic circulation time compared to free DOX. The fluorescence signal of PNPs efficiently and selectively increased in bladder cancer cells but not normal urothelial cells in vitro and in an orthotopic patient derived bladder cancer xenograft (PDX) models, indicating their great potential for photodynamic diagnosis. Photodynamic therapy with PNPs was significantly more potent than 5-aminolevulinic acid, and eliminated orthotopic PDX bladder cancers after intravesical treatment. Image-guided photodynamic and photothermal therapies synergized with targeted chemotherapy of DOX and significantly prolonged overall survival of mice carrying PDXs. In conclusion, this uniquely engineered targeting PNP selectively targeted tumor cells for photodynamic diagnosis, and served as effective triple-modality (photodynamic/photothermal/chemo) therapeutic agents against bladder cancers. This platform can be easily adapted to individualized medicine in a clinical setting and has tremendous potential to improve the management of bladder cancer in the clinic.

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“…PDT enhances vascular permeability leading to increased tumoral accumulation of macromolecular therapeutic agents 188. Snyder et.…”

Section: Harnessing Local and Systemic Biological Responses To Enhancmentioning

confidence: 99%

Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy

Mallidi¹,

Anbil

Bulin³

et al. 2016

Theranostics

320

226

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Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the generation of cytotoxic species through the interactions of a photosensitizer molecule with light irradiation of an appropriate wavelength. PDT is an approved therapeutic modality for several cancers globally and in several cases has proved to be effective where traditional treatments have failed. The key parameters that determine PDT efficacy are 1. the photosensitizer (nature of the molecules, selectivity, and macroscopic and microscopic localization etc.), 2. light application (wavelength, fluence, fluence rate, irradiation regimes etc.) and 3. the microenvironment (vascularity, hypoxic regions, stromal tissue density, molecular heterogeneity etc.). Over the years, several groups aimed to monitor and manipulate the components of these critical parameters to improve the effectiveness of PDT treatments. However, PDT is still misconstrued to be a surface treatment primarily due to the limited depths of light penetration. In this review, we present the recent advances, strategies and perspectives in PDT approaches, particularly in cancer treatment, that focus on increasing the 'damage zone' beyond the reach of light in the body. This is enabled by a spectrum of approaches that range from innovative photosensitizer excitation strategies, increased specificity of phototoxicity, and biomodulatory approaches that amplify the biotherapeutic effects induced by photodynamic action. Along with the increasing depth of understanding of the underlying physical, chemical and physiological mechanisms, it is anticipated that with the convergence of these strategies, the clinical utility of PDT will be expanded to a powerful modality in the armamentarium for the management of cancer.

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Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Cited by 352 publications

References 231 publications

Yolk–Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic–Plasmonic Hybrid Theranostic Platform

Yolk–Shell Nanostructure: An Ideal Architecture to Achieve Harmonious Integration of Magnetic–Plasmonic Hybrid Theranostic Platform

Novel theranostic nanoporphyrins for photodynamic diagnosis and trimodal therapy for bladder cancer

Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy

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