Cancer mortality after radiotherapy for a skin hemangioma during childhood

Dondon, Marie-Gabrielle

doi:10.1016/s0167-8140(04)00203-8

Cited by 3 publications

(6 citation statements)

References 8 publications

(11 reference statements)

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“…Careful examination is recommended in these cases not to bypass possible radio-induced lesions [36]. The increased cancer-related mortality was observed in patients who underwent radiotherapy for skin vascular anomalies and they should be followed up later on [6].…”

Section: Discussionmentioning

confidence: 99%

“…Radiotherapy was one of the most common ways to treat vascular anomalies in Europe until the 1960s. In those days this approach to the vascular anomalies seemed to be harmless and generally accepted as a non-invasive treatment causing no scaring [2,6,7]. It was advocated to initiate the therapy as early as possible to stop the evolution of this lesion because it was believed that vascular anomalies in younger children is much sensitive to radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

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Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy

Mańkowski¹,

Osmola‐Mańkowska²,

Olszański³

et al. 2012

pdia

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A b s t r a c tIn the past, vascular anomalies were divided into vascular malformations and vascular tumors. Radiotherapy was one of the leading methods of treatment for vascular malformations and infantile haemangiomas in the past and considered as harmless in those days. Many years later it turned out that management was not necessary and dangerous, even responsible for possible skin cancers appeared within areas exposed to radiotherapy in the future. The case report shows the presence of squamous cell carcinoma within the irradiated vascular malformation of the frontotemporal area in early childhood. The lesion was surgically removed, the defect was covered by split thickness skin graft. The histopathological evaluation confirmed the carcinoma as well as its complete resection. Assessing the adult patients with vascular anomaly one should be aware of possible radiation therapy for that malformation in the past, then the evaluation of the skin must be careful and focused on possible neoplasmatic lesions. K Ke ey y w wo or rd ds s: : radiotherapy, vascular malformations, squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy

Mańkowski¹,

Osmola‐Mańkowska²,

Olszański³

et al. 2012

pdia

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“…7 Ionizing radiation from radon containing gold seeds and radium-containing tubes, sheets, and needles was routinely used to treat a variety of benign and malignant tumors and skin conditions until the early 1970s. 8 Throughout the 1950s and 1960s, ionizing radiation was commonly used to successfully treat cutaneous hemangiomas in children. 8,9 One popular treatment method entailed inserting radon seeds into the skin and leaving them in place indefinitely.…”

Section: Discussionmentioning

confidence: 99%

“…8 Throughout the 1950s and 1960s, ionizing radiation was commonly used to successfully treat cutaneous hemangiomas in children. 8,9 One popular treatment method entailed inserting radon seeds into the skin and leaving them in place indefinitely. These gold seeds contained radon-222 (alpha particle emitter, t 1/ 2 = 3.8 days), and most useful radiation from these radon seeds lasted only 1 to 8 weeks.…”

Section: Discussionmentioning

confidence: 99%

“…A number of long-term studies have revealed a significantly increased rate of various malignancies, including BCCs, in patients who underwent radiotherapy for hemangiomas. 8,9,12,13 As well, numerous case reports have documented BCCs arising at sites of previously irradiated tinea capitis, 14 port-wine stains, 15,16 and hemangiomas. 17,18 In these reports, BCCs typically arose 10 to 50 years after low-dose irradiation of the skin.…”

Section: Discussionmentioning

confidence: 99%

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