Cancer control-A global perspective

Olver, Ian

doi:10.1111/ecc.12654

Cited by 12 publications

(12 citation statements)

References 32 publications

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“…The IAEA are currently focusing to introduce radiotherapy to many of these countries. Moreover, it could be seen that investing in radiotherapy will save lives as well as have positive impact over economic benefits [2]. gradually rising in many countries.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line

R¹,

Iyer²

2020

Egypt Liver Journal

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Background: Currently, nanomaterials (NMs) research and development is at a fastest pace due to the enhanced implication in different areas of applications. The synthesis of such NMs through biosynthesis methods is gaining much importance because of low cost involved and environment-friendly approach. In this present study, the nanoparticles (NPs) are synthesized using a medicinal plant, with anticancer properties so as to incorporate the therapeutic activity within the NPs, such that the NPs will have the attributes of NMs alongside the phytoactivity. Results: The synthesis of gold nanoparticles (AuNPs) using Graviola, the fruit of Annona muricata (Ramaphal fruit) commonly referred as Mullu seetha fruit (Tamil), was successfully carried out. The initial confirmations of the NPs were using UV-vis spectra, which showed the characteristic peak for the NPs. HRSEM analysis gave an insight on the size and morphology of the NPs. The zeta potential was measured to check the stability of the NPs. The cytotoxicity was carried out in VERO cell line and anticancer study in Hep2 liver cancer cell line. The surface plasmon resonance (SPR) band showed the characteristic peak at 536 nm for the AuNPs. In SEM micrographs, the size was ranging between 20 and 30 nm, on an average of 15 nm with spherical morphology. On the various tested concentrations in VERO cell line, the nanoparticles were non-toxic to the cells. The anticancer study gave an IC50 value at 10.94 μg/ml. Conclusions:The NPs showed anticancer activity in treated Hep2 liver cancer cell line and as well as commendable non-toxic effect on normal VERO cell line. The results pose a positive impact to expand further studies in the development of potential drug molecules to tackle the disease of interest.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line

R¹,

Iyer²

2020

Egypt Liver Journal

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“…Comprehensive cancer care requires a number of interventions, ranging from specialized diagnostics to various treatments including: surgery, radiotherapy, and chemotherapy [1,2]. Low-cost and effective medicines to treat several cancers exist in generic form [3].…”

Section: Introductionmentioning

confidence: 99%

Availability, prices, and affordability of selected essential cancer medicines in a middle-income country – the case of Mexico

Moye-Holz

Ewen

Dreser

et al. 2019

Preprint

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Background: More alternatives have become available for the diagnosis and treatment of cancer in low- and middle-income countries. Because of increasing demands, governments are now facing a problem of limited affordability and availability of essential cancer medicines. Yet, precise information about the access to these medicines is limited, and the methodology is not very well developed. Objective: To assess the availability and affordability of essential cancer medicines in Mexico, and compare their prices against those in other countries of the region. Methods: We surveyed 21 public hospitals and 19 private pharmacies in 8 states of Mexico. Data were collected on the availability and prices of 49 essential cancer medicines. Prices were compared against those in Chile, Peru, Brazil, Colombia and PAHO’s Strategic Fund. Results: Of the various medicines, mean availability in public and private sector outlets was 61.2% and 67.5%, respectively. In the public sector, medicines covered by the public health insurance “People’s Health Insurance” were more available. Only seven (public sector) and five (private sector) out of the 49 medicines were considered affordable. Public sector procurement prices were 41% lower than in other countries of the region. Conclusions: The availability of essential cancer medicines, in the public and private sector, falls below World Health Organization’s 80% target. The affordability remains suboptimal as well. A national health insurance scheme could serve as a mechanism to improve access to cancer medicines in the public sector. Comprehensive pricing policies are warranted to improve the affordability of cancer medicines in the private sector.

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“…The main data of articles were tabulated as follows: (1) basic characteristics: first author's last name, publication year, country, and ethnicity; (2) clinical data: tumor type, gender, case number, age, treatment, tumor stage, follow-up duration, and detected method; (3) cut-off value and high expression number; and (4) HRs for OS, DFS, DSS, PFS, RFS, as well as their 95% CIs. In cases wherein the study provided the results of univariate and multivariate analyses, we chose the latter.…”

Section: Data Extraction and Conversionmentioning

confidence: 99%

Prognostic Role of High Stathmin 1 Expression in Patients with Solid Tumors: Evidence from a Meta-Analysis

Mao

Chen

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Several recent studies have demonstrated that Stathmin 1expression may be closely associated with prognosis in patients with various types of cancers. In the present study, we conducted a meta-analysis of all available studies in the English literature to assess the prognostic value of Stathmin 1expression in patients with solid cancers. Methods: The online databases PubMed, Embase, and Web of Science were searched for literature regarding Stathmin 1 and its association with patient outcomes associated with solid cancers. Results: A total of 23 articles including 26 studies that contained 5 335 patients were retrieved and analyzed. Our results indicated that high Stathmin 1 expression yielded a worse overall survival (OS) (hazard ratio [HR] = 2.17, 95% confidence interval [CI]: 1.81–2.60), disease-free survival (DFS) (HR = 2.46, 95% CI: 2.00–3.02), disease-specific survival (DSS) (HR = 1.98, 95% CI: 1.58– 2.47) and progression-free survival (PFS)/recurrence-free survival (RFS) (HR = 2.09, 95% CI: 1.51–2.89). Furthermore, the association of high Stathmin 1 expression with poor survival was significant even for sub-group analyses of different tumor types, ethnicities, methods used to calculate HRs, detected methods, and analysis types. Conclusion: In summary, this meta-analysis determined that high Stathmin 1 expression is associated with poor prognosis in patients with solid cancers and expression of this protein could be a clinically useful prognostic biomarker.

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Cancer control-A global perspective

Cited by 12 publications

References 32 publications

Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line

Antiproliferative effects on tumor cells of the synthesized gold nanoparticles against Hep2 liver cancer cell line

Availability, prices, and affordability of selected essential cancer medicines in a middle-income country – the case of Mexico

Prognostic Role of High Stathmin 1 Expression in Patients with Solid Tumors: Evidence from a Meta-Analysis

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