Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics

Montalvo-Quirós, Sandra; Aragoneses-Cazorla, Guillermo; Garcia-Alcalde, Laura; Vallet‐Regí, María; González, Blanca; Luque-García, José L.

doi:10.1039/c8nr07667g

Cited by 46 publications

(34 citation statements)

References 86 publications

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“…Figure 4 shows a schematic representation of the versatility and functionality of MSNs regarding their biomedical applications. Initially, these nanocarriers have shown high interest in cancer treatment due to the wide versatility in their functionalization, being able to design smart nanomaterials with stimulus responsive components [10,111], possessing also cancer cell targeting capability [112] and penetrability towards the deepest areas of solid tumors [113]. Recently, this technology has been also successfully applied to osteoporosis treatment in an animal model [12].…”

Section: Nanomaterials With Unique Features As Potential Weapons Tmentioning

confidence: 99%

Nanomaterials as Promising Alternative in the Infection Treatment

Vallet‐Regí

González

Izquierdo‐Barba

2019

IJMS

Self Cite

143

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Both the prevalence of antibiotic resistance and the increased biofilm-associated infections are boosting the demand for new advanced and more effective treatment for such infections. In this sense, nanotechnology offers a ground-breaking platform for addressing this challenge. This review shows the current progress in the field of antimicrobial inorganic-based nanomaterials and their activity against bacteria and bacterial biofilm. Herein, nanomaterials preventing the bacteria adhesion and nanomaterials treating the infection once formed are presented through a classification based on their functionality. To fight infection, nanoparticles with inherent antibacterial activity and nanoparticles acting as nanovehicles are described, emphasizing the design of the carrier nanosystems with properties targeting the bacteria and the biofilm.

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Section: Nanomaterials With Unique Features As Potential Weapons Tmentioning

confidence: 99%

Nanomaterials as Promising Alternative in the Infection Treatment

Vallet‐Regí

González

Izquierdo‐Barba

2019

IJMS

Self Cite

143

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“…Another notable result agrees where HepG2 cells incased GSH levels (1.1-fold), along with SOD activity. Overall, around 10% cell viability (survival rate) has decreased by AgNPs exposure [130,131]. Also, the cytotoxicity was delivered to induce diminished GSH levels which may reflect an oxidative stress [99,132,133].…”

Section: Topology Of Antioxidant Defense Metabolismmentioning

confidence: 99%

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Ganesan

Jang

Suh

et al. 2020

Cancers

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Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional heterogeneity, microenvironmental differences, and reversible changes in cell properties (e.g., chemotherapy). There is a lack of targets for processes involved in tumor cellular heterogeneity, such as metabolic clampdown, cytotoxicity, and genotoxicity, which hinders microenvironmental biology. Proteogenomics and chemical metabolomics are important tools that can be used to study proteins/genes and metabolites in cells, respectively. Chemical metabolomics have many advantages over genomics, transcriptomics, and proteomics in anticancer therapy. However, recent studies with AgNPs have revealed considerable genomic and proteomic changes, particularly in genes involved in tumor suppression, apoptosis, and oxidative stress. Metabolites interact biochemically with energy storage, neurotransmitters, and antioxidant defense systems. Mechanobiological studies of AgNPs in cancer metabolomics suggest that AgNPs may be promising tools that can be exploited to develop more robust and effective adaptive anticancer therapies. Herein, we present a proof-of-concept review for AgNPs-based proteogenomics and chemical metabolomics from various tumor cells with the help of several technologies, suggesting their promising use as drug carriers for cancer therapy.

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“…In addition to peptidic fragments, the use of biocompatible proteins has also yielded MSNs with high tumor specificity. In this regard, the overexpression of the transferrin receptor in many types of cancer has boosted the use of this protein as recognition moiety [ 57 , 58 , 59 , 60 ]. Additional approximations involve the use of proteins such as concanavalin-A (sialic acids) [ 61 ] or Aleuria Aurantia (sialyl-Lewis X antigen) [ 62 ], among others.…”

Section: Basic Principles Of Cancer Nanomedicinementioning

confidence: 99%

Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

Gisbert-Garzarán

Lozano

Vallet‐Regí

2020

IJMS

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Current chemotherapy treatments lack great selectivity towards tumoral cells, which leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of nanoparticles able to encapsulate and release therapeutic agents has attracted growing attention. In this sense, mesoporous silica nanoparticles (MSNs) have been widely employed as drug carriers owing to their exquisite physico-chemical properties. Because MSNs present a surface full of silanol groups, they can be easily functionalized to endow the nanoparticles with many different functionalities, including the introduction of moieties with affinity for the cell membrane or relevant compartments within the cell, thus increasing the efficacy of the treatments. This review manuscript will provide the state-of-the-art on MSNs functionalized for targeting subcellular compartments, focusing on the cytoplasm, the mitochondria, and the nucleus.

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Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: insights into the action mechanisms using quantitative proteomics

Abstract: An approach for safely delivering AgNPs to cancer cells and the evaluation of the affected cellular mechanism are presented.

Cited by 46 publications

References 86 publications

Nanomaterials as Promising Alternative in the Infection Treatment

Nanomaterials as Promising Alternative in the Infection Treatment

Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review

Mesoporous Silica Nanoparticles for Targeting Subcellular Organelles

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