Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Zhang, Xiao; He, Shuqing; Ding, Bingbing; Qu, Chunrong; Zhang, Qing; Chen, Hao; Sun, Yu; Fang, Hanyi; Lei, Yu; Zhang, Ruiping; Lan, Xiaoli; Cheng, Zhen

doi:10.1016/j.cej.2019.123959

Cited by 96 publications

(66 citation statements)

References 35 publications

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“…Although surface coating of Ln 3+ -containing NIR-II nanoprobes with inorganic shells or organic polymers has been demonstrated to improve their biocompatibility, the targeting efficiency is still unsatisfied because of the poor accumulation ability and insufficient retention time. Hence, the surface engineering with bioactive agents such as antibodies ( You et al., 2018 ), DNA strings ( Dumont et al., 2012 ), cancer cell membrane ( Zhang et al., 2020b ), and viruses ( Zhang et al., 2017 ) was developed, which can significantly improve the selectivity of Ln 3+ -containing NIR-II nanoprobes toward specific targets and enhance their targeting efficiency. For instance, human serum albumin (HSA) was modified on the surface of NaYF 4 :Yb 3+ , Er 3+ @NaYF 4 NPs and magnified the accumulation of the NPs in tumor tissue by more than 10 times as compared with the uncoated counterparts ( Naczynski et al., 2013 ).…”

Section: Surface Functional Modificationmentioning

confidence: 99%

“…Recently, cancer cell membrane was reported to modify NaYF 4 :Nd 3+ @NaYF 4 nanoprobes for improved performance in tumor detection and tumor surgery navigation. Cancer cell membrane can camouflage nanoprobes to avoid fast clearance and macrophage ( Zhang et al., 2020b ). Thus, such cancer-cell-membrane coated nanoprobes exhibited significantly higher accumulation in the tumor and significantly enhanced blood retention compared to the counterparts with PEG encapsulation.…”

Section: Surface Functional Modificationmentioning

confidence: 99%

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Recent advances in design of lanthanide-containing NIR-II luminescent nanoprobes

Yang

Zhang

et al. 2021

iScience

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Summary Luminescent biosensing in the second near-infrared window (NIR-II, 1000–1700 nm) region, which has weak tissue scattering and low autofluorescence, draws extensive attention owing to its deep tissue penetration, good spatial resolution and high signal-to-background ratio. As a new generation of NIR-II probes, lanthanide (Ln 3+ )-containing nanoprobes exhibit several superior properties. With the rapid development of Ln 3+ -containing NIR-II nanoprobes, many significant advances have been accomplished in their optical properties tuning and surface functional modification for further bioapplications. Rather than being exhaustive, this review aims to survey the recent advances in the design strategies of inorganic Ln 3+ -containing NIR-II luminescent nanoprobes by highlighting their optical performance optimization and surface modification approaches. Moreover, challenges and opportunities for this kind of novel NIR-II nanoprobes are envisioned.

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Section: Surface Functional Modificationmentioning

confidence: 99%

Section: Surface Functional Modificationmentioning

confidence: 99%

Recent advances in design of lanthanide-containing NIR-II luminescent nanoprobes

Yang

Zhang

et al. 2021

iScience

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“…As a natural progression, another up-conversion particles accumulation in tumour site was made use of by Zhang et al The author showed that NaYF 4 :Nd5@NaYF 4 nanoparticles were prepared with an optimized proportion of 5% Nd 3 + for imaging-guided tumour surgery using NIR laser. [86] The formulation was excitable at 808 nm and had emission at 1064 nm. Two methods such as coating with PEG and/or cancer cell membrane were further cross-checked against each other.…”

Section: Other Unique Uses Of Membrane Coatingmentioning

confidence: 99%

Cancer Cell Membrane Technology for Cancer Therapy

et al. 2020

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Even after decades of research, one of the most significant challenges in nanotechnology-based cancer therapy is to increase the target specificity and to reduce the side effects. As a result, even after substantial progress in lab-scale research, clinical trials have mostly failed. One of the emerging new strategies to increase the target specificity and to increase the chemotherapeutic efficacy is to mimic biological moieties using cellular membranes. Owing to its preferential accumulation at the tumor site, cancer cell membrane presents itself as a promising surface functionalization to the nanocarriers. This review aims to summarize recent reports on the cancer cell membrane and the hybrid membrane-associated research for the comprehensive understanding of their successful implementation in cancer therapy.

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“…2 Recent studies, including those regarding the detection of metastatic lymph nodes, 3 tumor and vessel imaging, [4][5][6] and intraoperative guidance, 7,8 have shown that biological imaging advantages significantly improves as wavelengths increase. Thus far, quantum dots, [9][10][11] carbon nanotubes, 12,13 rare earth-doped nanoparticles, 14,15 squaraine dyes, 16,17 semiconducting polymer nanoparticles, 18 and small-molecule dyes 5,19,20 have all been actively used for NIR-II imaging. The recent rapid development of small molecule dyes, in particular, has led to the use of effective probes for NIR-II fluorescence bioimaging.…”

Section: Introductionmentioning

confidence: 99%

<p>Facile Synthesis of Melanin-Dye Nanoagent for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal Therapy</p>

Sun¹,

Cai²,

Sun³

et al. 2020

IJN

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Background Laryngeal cancer is the second most common type of primary epithelial malignant tumor in the head and neck region, and the development of therapies that are more precise, efficient, and safe is necessary to preserve patient speech and swallowing functions as much as possible. Multi-modal imaging-guided photothermal therapy (PTT) can precisely delineate tumors, monitor the real-time accumulation of photothermal agents at the tumor site, accurately select the optimal region for irradiation, and predict the best time for laser treatment. Compared with exogeneous photothermal agents, endogenous melanin materials have better biosafety in vivo, in terms of native biocompatibility and biodegradability, as well as good near-infrared (NIR) absorbance. An NIR-II dye can be attached to melanin via a facile method, and applying a melanin-dye-based nanoprobe could be an excellent choice for the elimination of superficial laryngeal cancer while avoiding total laryngectomy. Methods In this work, a promising nanoprobe was constructed using a facile EDC/NHS strategy involving an NIR-II dye and melanin nanoparticles. Results The nanoprobe exhibited good water solubility, dispersibility, strong NIR-II fluorescence and photoacoustic (PA) signals, and higher photothermal performance. Cellular studies showed that the nanoprobe had low toxicity, excellent biocompatibility, and significantly enhanced imaging properties. After the nanoprobe was intravenously injected into Hep-2 laryngeal xenografts, superior dual-modal images were obtained at various time points, which revealed that the optimal photothermal treatment time was 8 h. Subsequently, PTT was carried out in vivo, and laryngeal tumors were completely eliminated after laser irradiation without any obvious side effects. Conclusion These results indicate the immense potential of nanoprobes for the NIR-II fluorescence/PA imaging-guided photothermal therapy of laryngeal cancer.

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Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window

Cited by 96 publications

References 35 publications

Recent advances in design of lanthanide-containing NIR-II luminescent nanoprobes

Recent advances in design of lanthanide-containing NIR-II luminescent nanoprobes

Cancer Cell Membrane Technology for Cancer Therapy

<p>Facile Synthesis of Melanin-Dye Nanoagent for NIR-II Fluorescence/Photoacoustic Imaging-Guided Photothermal Therapy</p>

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