Cancer Cell Membrane Technology for Cancer Therapy

Abstract

Even after decades of research, one of the most significant challenges in nanotechnology-based cancer therapy is to increase the target specificity and to reduce the side effects. As a result, even after substantial progress in lab-scale research, clinical trials have mostly failed. One of the emerging new strategies to increase the target specificity and to increase the chemotherapeutic efficacy is to mimic biological moieties using cellular membranes. Owing to its preferential accumulation at the tumor site, cancer cell membrane presents itself as a promising surface functionalization to the nanocarriers. This review aims to summarize recent reports on the cancer cell membrane and the hybrid membrane-associated research for the comprehensive understanding of their successful implementation in cancer therapy.

Amphiphilic and Zwitterionic Multi Arylpyrroles with Near‐Infrared Aggregation‐Induced Emission for Cell Membrane Imaging

“…Generally, the morphology of the plasma membrane can reflect the spontaneous state of the cell. Moreover, fluorescent imaging is an efficient tool to illuminate cell membranes and monitor the cellular enrichment and internalization of therapeutic nanoparticles [7] . Therefore, how to clearly target the cell membrane through specific fluorescent dyes has been of great interest in recent years.…”