Can the CRP/albumin Ratio be Used as a New Indicator of Activation in Patients with Uveitis?

Bozkurt, Erdinç; Muhafız, Ersin; Sengul, Dilek; Uçak, Turgay; Atum, Mahmut

doi:10.1080/09273948.2020.1714061

Cited by 17 publications

(10 citation statements)

References 39 publications

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“…Although no previous studies evaluated the relationship between the CAR and PsAID-12 scores in PsA, some studies showed an increased CAR in patients with cancer and those in intensive care, as well as the association of CAR with inflammation ( 21 - 23 ). In addition, in a study by Bozkurt et al ( 24 ) on 35 patients with uveitis episodes and 35 healthy controls, the CAR was an important indicator of uveitis activation. However, few studies investigated acute phase reactants and the CAR in autoimmune diseases.…”

Section: Discussionmentioning

confidence: 92%

Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

Duran

Pamukçu

2022

Croat Med J

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Aim To evaluate the relationships between the C-reactive protein (CRP)/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and Disease Activity in Psoriatic Arthritis (DAPSA) and Psoriatic Arthritis Impact of Disease 12-item-questionnaire (PsAID-12) scores in patients with psoriatic arthritis (PsA). Methods This cross-sectional study involved 160 (121 female) patients with PsA who were >18 years old and treated in the rheumatology clinic of Dışkapı Yıldırım Beyazıt Education and Research Hospital between January 2020 and January 2021. Demographic and clinical data, PsAID-12 and DAPSA scores, CRP, erythrocyte sedimentation rate (ESR), albumin level, neutrophil, lymphocyte, and platelet counts were recorded. Results The mean age was 46.49 ± 11.12 years; median (min-max) disease duration was 2 years (0.5-34). The PsAID score was ≥4 (high disease impact) in 74.4% of patients. Patients with high disease impact had significantly higher CRP, ESR, CAR, NLR, PLR, neutrophil counts, and DAPSA scores ( P < 0.001). PsAID scores significantly highly correlated with CRP (rho 0.864, P < 0.001), DAPSA significantly highly correlated with the CAR (rho 0.890, P < 0.001). Receiver operating characteristic curve analysis showed that the CAR (area under the curve [AUC] 0.901, P < 0.05, 95% confidence interval [CI] 0.855-0.947, NLR (AUC 0.759, P < 0.05, 95% CI 0.680-0.838), and PLR (AUC 0.686, P < 0.05, 95% CI 0.591-0.782) predicted high disease impact. The cut-off value for the CAR was 0.98. Conclusion The CAR can be useful in daily practice as a simple and quick assessment method to evaluate disease impact in PsA.

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Section: Discussionmentioning

confidence: 92%

Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

Duran

Pamukçu

2022

Croat Med J

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“…Among several laboratory parameters assessed in many studies, lymphocyte, platelet, albumin, C-reactive protein (CRP), fibrinogen, procalcitonin, D-dimer, interleukin-6, and their derived neutrophil/lymphocyte ratio (NLR) and fibrinogen/albumin ratio (FAR) have been proposed as predictive markers for the severity of COVID-19 [5][6][7][8][9] . The CRP/albumin ratio (CAR) is a novel index calculated by dividing the CRP to albumin level, and many studies have shown that CAR can be used to predict the activity, severity, and prognosis of various conditions [10][11][12][13] . However, whether CAR is an efficient indicator in determining the severity of COVID-19 has not been investigated so far.…”

Section: Introductionmentioning

confidence: 99%

The value of C-reactive protein/albumin, fibrinogen/albumin, and neutrophil/lymphocyte ratios in predicting the severity of CoVID-19

Torun

Çakırca

Çakırca³

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE: This retrospective study aimed to determine the predictive values of the C-reactive protein (CRP)/albumin ratio (CAR), fibrinogen/albumin ratio (FAR), and neutrophil/lymphocyte ratio (NLR) parameters, which reflect the systemic inflammatory status, for the severity of COVID-19.METHODS: A total of 188 patients diagnosed with COVID-19 were enrolled in this study. Among them, 118 were in the severe group, and 70 were in the non-severe group. Levels of albumin, CRP, D-dimer, procalcitonin, fibrinogen, and hemoglobin; leukocyte, neutrophil, lymphocyte, and monocyte counts; and the FAR, CAR, and NLR were compared between the two groups. RESULTS:The CAR, FAR, and NLR values were significantly higher in the severe group compared to the non-severe group. CAR, FAR, and NLR were positively correlated with leukocyte and neutrophil counts and CRP, procalcitonin, and fibrinogen levels. On the other hand, they were inversely correlated with monocyte (except for NLR) and lymphocyte counts. Receiver operator characteristic analysis showed that the area under the curve (AUC) for CAR, FAR, and NLR was 0.841, 0.737, and 0.802, respectively. CONCLUSIONS: Our investigation revealed that the CAR, FAR, and NLR indices can be used to predict the severity of COVID-19, among which CAR was the best predictor of severe COVID-19.

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“…In a prior study, serum levels of another acute phase protein, alpha-1-acid glycoprotein (also termed ORM), was related to the severity of inflammation in patients with idiopathic AAU [15]. A recent study suggested that the acute phase response protein c-reactive protein (CRP) in serum could be an indicator of the degree of inflammation in anterior uveitis [6]. This finding is in accordance with our study, in which SERPINA3 was correlated with the degree of anterior chamber flare in the affected eyes of AAU patients.…”

Section: Discussionmentioning

confidence: 99%

The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis

Eidet

Akopian

Olstad

et al. 2021

J Ophthal Inflamm Infect

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Background To identify candidate tear fluid biomarkers in patients with unilateral acute anterior uveitis (AAU) that can aid in the differentiation between these patients and patients with bacterial keratitis or healthy controls. Methods Thirteen patients (40.1 ± 16.2 years of age) with unilateral AAU, seven patients with unilateral bacterial keratitis (40.2 ± 15.3 years of age), and 14 healthy subjects (41.1 ± 11.6 years of age) were included. The tear proteome of affected eyes was compared with that of the unaffected eye or healthy controls. Proteins were identified by liquid chromatography tandem mass spectrometry and enzyme-linked immunosorbent assay. Results Relative protein ratios were detected and calculated for 272 unique proteins. Compared with healthy controls and the unaffected eye, the top upregulated proteins in AAU eyes were submaxillary gland androgen regulated protein 3B (SMR3B) and SMR3A. Similarly, the top upregulated proteins in bacterial keratitis were S100 calcium-binding protein A9 and orosomucoid 2. The acute phase response protein Serpin Family A Member 3 (SERPINA3) was increased in the healthy eye of AAU patients (P = 0.019) compared with healthy controls. Laser flare measurements in affected eyes of AAU patients showed positive logarithmic correlation with SERPINA3 in tear samples of the unaffected eye (P = 0.022). The use of SERPINA3 as a tear biomarker yielded a sensitivity of 85% and a specificity of 71% in detecting patients with AAU in the study population. Conclusions The acute phase response protein SERPINA3 was increased in tear samples of unaffected eyes of patients with unilateral AAU compared with healthy controls. This study highlights SERPINA3 as a potential biomarker for AAU. Future research should explore the dynamic properties of SERPINA3 in the tear fluid of active and quiescent uveitis eyes.

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Can the CRP/albumin Ratio be Used as a New Indicator of Activation in Patients with Uveitis?

Cited by 17 publications

References 39 publications

Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

The value of C-reactive protein/albumin, fibrinogen/albumin, and neutrophil/lymphocyte ratios in predicting the severity of CoVID-19

The acute phase response protein SERPINA3 is increased in tear fluid from the unaffected eyes of patients with unilateral acute anterior uveitis

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