Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

Duran, Tuğba İzci; Pamukçu, Melih

doi:10.3325/cmj.2022.63.141

Cited by 8 publications

(5 citation statements)

References 27 publications

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“…According to the result of our study there is positive significant correlation between DAPSA score with ESR (rho =o.4o6), CRP (rho=0.482). This result in line with other two studies done by Duran , Pamuk , 2022 (22), and by Tam et al, 2008(23). However, another study by Pamuk et al, (2009) found that CRP not correlated with disease activity (24).…”

Section: Resultssupporting

confidence: 93%

Association Between Mean Platelet Volume And Disease Activity In Patients With Psoriatic Arthritis

Mustafa¹,

Esho²

2022

IJP

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Background: Mean platelet volume is an important marker that shows the activation and function of the platelet which is effective in the inflammatory process. Aim of the study:To show the relationship between mean platelet volume and disease activity score in psoriatic arthritis patients (PsA). Methods: a cross-sectional study was done. A total of 90 patients participated in the study. The sample was collected over 6 months. Mean platelet volume was measured and correlated with disease activity score, and the relation between mean platelet volume with other disease activity markers like erythrocyte sedimentation rate (ESR) and C-reactive proteins (CRP)was determined. The serum of (cholesterol, tri-glycerides, low density lipoproteins, and high density lipoproteins) were estimated and correlated with DAPSA scores. Results: The mean (SD) of MPV was 10.4fl .It is evident in Psoriatic arthritis patients that around two thirds (64.9%) of patients were with high MPV and 39.4% of patients were with normal MPV. There is statistically significant positive correlation between the MPV and the DAPSA score, and the positive significant correlation between disease activity score with ESR, and CRP. Also, there was a positive correlation between s. cholesterol, s. triglyceride, LDL and DAPSA score while a negative significant correlation was found between DAPSA score and HDL. Conclusion: Higher disease activity in PsA patients is associated with correspondingly high MPV and high level of inflammatory markers like ESR and CRP, and lipid profiles.

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Section: Resultssupporting

confidence: 93%

Association Between Mean Platelet Volume And Disease Activity In Patients With Psoriatic Arthritis

Mustafa¹,

Esho²

2022

IJP

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“…The second was to investigate the relationship between CAR, PLR and NLR and the risk of persistent disease activity during follow up. CRP and CAR levels were found to be significantly higher in JIA patients as compared to controls, as reported in previous studies on adult patients with RA, axSpA and psA [8,10,11]. Otherwise, ESR, PLR and NLR were not different between the two groups.…”

Section: Discussionsupporting

confidence: 86%

“…Moreover, He Y. et al demonstrated a correlation between CAR and Th17 cells and cytokine expression in patients with RA [9]. Other authors reported similar results in adult patients with axial spondyloarthritis (axSpA) [10] and psoriasic arthritis (psA) [11]. Besides, several reports have suggested the potential role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as inflammatory markers and complementary diagnostic tools in RA and other rheumatic diseases [12,13].…”

Section: Introductionmentioning

confidence: 82%

“…CRP is synthesized by the liver and reflects systemic inflammation, so that it is widely used as inflammatory Recently, it has emerged as a novel biomarker for evaluating disease activity in some rheumatic diseases [6][7][8][9][10][11]. Furthermore, growing evidence are pointing out the potential prognostic value of blood cell count ratios, like NLR and PLR, as non-specific inflammatory markers [12,13].…”

Section: Discussionmentioning

confidence: 99%

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Associations of C reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio with disease activity in patients with juvenile idiopathic arthritis

Di Donato,

Attanasi,

Mariarita d’ Angelo

et al. 2024

BMC Rheumatol

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Introduction Recent works in the scientific literature reported the role of C reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as biomarkers of disease activity in rheumatic diseases. Objectives To investigate the role of CAR, PLR and NLR as potential markers of disease activity in children with non-systemic JIA (nsJIA) and their correlation with the risk of persistent disease activity of flare during follow up. Methods Our prospective, cross-sectional study involved 130 nsJIA patients (74 with active disease and 56 with inactive disease according to Wallace criteria) and 62 healthy controls. Demographic, clinical and laboratory data were collected at baseline (T0) and at 3 (T1), 6 (T2), 12 (T3) and 18 months (T4) during follow up. Disease activity was evaluated through Juvenile Arthritis Disease Activity Score (JADAS-27). Results At baseline, CRP and CAR were higher in patients than in controls (p = 0.046), while no differences were found for NLR and PLR. However, there was no positive correlation between CAR, NLR, PLR and JADAS-27 in JIA patients. To better investigate the role of CAR, NLR and PLR as markers of disease activity, we used a generalized estimating equation (GEE) model, applied to all patients either with or without active disease. According to this analysis, CAR and NLR baseline levels were predictive of higher risk of disease activity at 6 months follow up (p < 0.001). Conclusions CAR and NLR could indicate persistent disease activity in patients with JIA. Their predictive value could be increased by their combined use and by the observation of their trend during follow up, since increasing CAR values over time could predict a disease flare in the brief time.

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“…Te neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), and platelet-to-lymphocyte ratio (PLR) have been associated with arthritis infammation, such as rheumatoid arthritis (RA) [4,5]. Both NLR and PLR are found to be higher in patients with a high impact of PsA [6]. Yorulmaz et al found that the systemic immune-infammation (SII) index was higher in patients with PsA than in those without, and it might serve as an independent prognostic indicator for patients with psoriasis and PsA [7].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Significance of the Derived Neutrophil‐to‐Lymphocyte Ratio in Differentiating Occult Psoriatic Arthritis from Psoriasis Alone

Yu,

Huang,

Jiang

et al. 2023

Dermatologic Therapy

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Background. Occult psoriatic arthritis (PsA) refers to a subset of psoriasis patients showing lesions on imaging but do not exhibit arthritis symptoms. Objective. This study was aimed to discover a simple biomarker that could be easily incorporated in clinical practice to identify occult PsA patients, defined as psoriasis patients with lesions on imaging but without arthritis symptoms, among silent psoriasis (PsO) patients, defined as psoriasis patients without any arthritis symptoms. Methods. A total of 149 silent PsO patients, including 83 PsO alone patients, defined as psoriasis patients without any arthritis symptoms and evidence of lesions on imaging, and 66 occult PsA patients, were enrolled in this cross-sectional study, and they all underwent blood tests to determine hematological inflammation biomarkers. Results. Occult PsA patients had a higher derived neutrophil-to-lymphocyte ratio (dNLR) (1.6 (1.3–2.2) vs. 1.3 (0.9–1.8), p < 0.001), body mass index (BMI) (25.2 (23.7–28.1) vs. 24.0 (21.9–26.0), p = 0.002), diabetes mellitus (DM) rate (30.3% vs. 7.2%, p < 0.001), and nail involvement rate (65.2% vs. 41.0%, p = 0.003) than patients with PsO alone. A prediction nomogram was established, and the area under the curve (AUC) was 0.843. The sensitivity and specificity of the model for identifying occult PsA patients were 77.3% and 81.9%, respectively. Conclusion. Our findings suggest that dNLR is a valuable diagnostic biomarker for occult PsA, and our prediction nomogram could provide clinicians with a useful tool for differentiating occult PsA patients from PsO alone patients.

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Relationship between disease impact scores and C-reactive protein/albumin ratio in patients with psoriatic arthritis

Cited by 8 publications

References 27 publications

Association Between Mean Platelet Volume And Disease Activity In Patients With Psoriatic Arthritis

Association Between Mean Platelet Volume And Disease Activity In Patients With Psoriatic Arthritis

Associations of C reactive protein to albumin ratio, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio with disease activity in patients with juvenile idiopathic arthritis

The Clinical Significance of the Derived Neutrophil‐to‐Lymphocyte Ratio in Differentiating Occult Psoriatic Arthritis from Psoriasis Alone

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