Can Placental Histopathological Lesions Be a Guide  to Maternal and Neonatal Outcomes in Patients With  Preeclampsia?

Atıgan, Ayhan; Kılıç, Derya; Güler, Ömer Tolga; Karakaya, Yeliz Arman

doi:10.26650/iuitfd.982918

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…When the villous cytotrophoblast integrates into the syncytium, the aged or damaged multinucleated syncytiotrophoblast passes through the maternal vascular compartment. According to one study, the decreased placental perfusion seen in preeclampsia affects the turnover of villous trophoblast cells [4]. Integrin beta-4 participates in hemidesmosomes responsible for cell proliferation, migration, and invasion [17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…Adhesion, proliferation and migration transactions are considerable for early pregnancy and the build up of a healthy placenta [3]. Although the etiology of PE has not been fully elucidated, placental defects may be due to insufficient or incomplete trophoblast cell invasion [4]. There is an increase in maternal placental vascular endothelial permeability [5].…”

Section: Introductionmentioning

confidence: 99%

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CD97 expression level and its effect on cell adhesion in Preeclampsia

Atıgan

Tan

Çetin

et al. 2022

BMC Pregnancy Childbirth

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Objectives Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. Methods This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. Results The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p = 0.002, p = 0.000, p = 0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p = 0.028, p = 0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65 ± 1,84 vs 2,06 ± 1,76 respectively; p = 0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50 ± 0,82 vs 2,43 ± 1,59 respectively; p = 0.049). Integrin beta-4 was not statistically different between groups. Conclusions Cellular interaction may be responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

CD97 expression level and its effect on cell adhesion in Preeclampsia

Atıgan

Tan

Çetin

et al. 2022

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…Adhesion, proliferation and migration transactions are considerable for early pregnancy and the build up of a healthy placenta [3]. Although the etiology of PE has not been fully elucidated, placental defects may be due to insu cient or incomplete trophoblast cell invasion [4]. There is an increase in maternal placental vascular endothelial permeability [5].…”

Section: Introductionmentioning

confidence: 99%

CD97 Expression Level and Its Effect on Cell Adhesion in Preeclampsia

Atıgan

Tan²,

Çetin³

et al. 2022

Preprint

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Objectives Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. Methods This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. Results The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p = 0.002, p = 0.000, p = 0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p = 0.028, p = 0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65 ± 1,84 vs 2,06 ± 1,76 respectively; p = 0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50 ± 0,82 vs 2,43 ± 1,59 respectively; p = 0.049). Integrin beta-4 was not statistically different between groups. Conclusions Cellular interaction is responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.

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“…Atigan et al en 2022, informaron que el peso de las placentas fue menor en el grupo de preeclampsia en comparación con el grupo de control. (41).…”

Section: Discussionunclassified

Alteraciones anatomopatológicas de la placenta con preeclampsia: una revisión sistemática

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Durán C. et al. Una revisión sistemática: Alteraciones anatomopatológicas de la placenta con preeclampsia: una revisión sistemática [Protocolo]. Se utilizarán cuatro bases de datos: SciELO, Lilacs, Google Scholar y Embase, para la revisión sistemática de estudios controlados aleatorizados y estudios observacionales de diseños transversales, cohorte, casos y controles, estudios de casos y series de casos, entre el 2002 a 2022.

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Can Placental Histopathological Lesions Be a Guide to Maternal and Neonatal Outcomes in Patients With Preeclampsia?

Cited by 4 publications

References 22 publications

CD97 expression level and its effect on cell adhesion in Preeclampsia

CD97 expression level and its effect on cell adhesion in Preeclampsia

CD97 Expression Level and Its Effect on Cell Adhesion in Preeclampsia

Alteraciones anatomopatológicas de la placenta con preeclampsia: una revisión sistemática

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