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PVF mesh induces less inflammation than PP mesh, and in both mesh types steroid soaking further decreases inflammation without changing the pore size.

Objectives Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. Methods This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. Results The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p = 0.002, p = 0.000, p = 0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p = 0.028, p = 0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65 ± 1,84 vs 2,06 ± 1,76 respectively; p = 0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50 ± 0,82 vs 2,43 ± 1,59 respectively; p = 0.049). Integrin beta-4 was not statistically different between groups. Conclusions Cellular interaction may be responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.

Objectives Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. Methods This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. Results The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p = 0.002, p = 0.000, p = 0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p = 0.028, p = 0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65 ± 1,84 vs 2,06 ± 1,76 respectively; p = 0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50 ± 0,82 vs 2,43 ± 1,59 respectively; p = 0.049). Integrin beta-4 was not statistically different between groups. Conclusions Cellular interaction is responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE.

Objectives: Cellular interactions and cell adhesion underlie preeclampsia (PE). The aim of the current study is to investigate the role of cell adhesion molecules such as CD97, neural (N)-cadherin, epithelial (E) -cadherin and integrin beta-4 in PE. Methods: This prospective study included 20 pregnant women with PE and a control group of 16 healthy pregnant women who were matched for age, gestational age, gravida and parity. Standard blood tests and placental cell adhesion molecule immunohistochemical staining were examined. Results: The creatinine, uric acid and lactate dehydrogenase (LDH) levels from standard blood tests were found to be statistically higher in the PE group (p=0.002, p=0.000, p=0.001; respectively). In the PE group, the CD97 maternal serum level was statistically significantly lower, as was its immunohistochemical expression in placental sections (p=0.028, p=0.000; respectively). The E-cadherin expression score was statistically higher in the PE group compared to the control group (3,65±1,84 vs 2,06±1,76 respectively; p=0.003). The N-cadherin expression score was statistically lower in the PE group compared to the control group (1,50±0,82 vs 2,43±1,59 respectively; p=0.049). Integrin beta-4 was not statistically different between groups. Conclusions: Cellular interaction is responsible for PE as in cancer. A balance in intercellular communication, as researched in cancer therapy, may offer the solution in PE. Keywords: Preeclampsia, Cadherins, CD97, E-cadherin, N-cadherin, Integrin beta-4

Mitokondriler, eritrositler dışında bütün hücrelerde bulunur ve kendi genetik materyaline sahiptir. [1,2] Mitokondrilerde 16,5 bp uzunluğunda küçük çift sarmal yapıda daire şeklinde DNA, iki ribozomal RNA, 23 tRNA ve 13 proteini kodlayan 37 gen vardır. [3] Mitokondri metabolik olaylarda, kalsiyum homeostasında, yağ asitleri oksidasyonunda ve apoptoziste önemli rol oynar. [4] Mitokondrilerin şekilleri küremsi veya uzun silindiriktir. Sayıları hücre tipine veya fonksiyonuna göre değişir. Mitokondriler hücrede hareket ederken şekil değiştirebilir. Sayı, dağılım ve morfolojik yapı bakımından oosit ve sperm mitokondrileri arasında bazı farklılıklar vardır. MtDNA'da (mitokondriyal DNA) histonlar yoktur ve DNA koruyucu mekanizmalardan yoksundur. Ayrıca mitokondri DNA'sı çekirdek DNA'sına