Can Panton Valentine Leukocidin Gene And Clindamycin Susceptibility Serve As Predictors of Community Origin of Mrsa From Skin and Soft Tissue Infections?

Abstract

Both Clindamycin susceptibility and pvl gene carriage were found to be independent predictors of community origin of MRSA, but taken together the association was highly significant.

Molecular Epidemiology of Panton-Valentine Leukocidin Harboring Hospital-Associated Methicillin-Resistant Staphylococcus aureus in Septicemic Children, Northeastern Iran, Bojnurd

“…It seems that PVL carrying phages were integrated into pre-existing endemic MRSA strains; therefore, a previously accepted hypothesis about markers of CA-MRSA strains could be speculated. Our findings and some previous studies suggest that the PVL gene could not be an appropriate marker for CA-MRSA (9,10,27,(37)(38)(39). Altogether, these findings are alarming with respect to the genetic background of these HA-MRSA strains (ST239/SCCmec III), since it is possible that these highly virulent strains spread to other hospitals in various geographical regions.…”

“…This is a twocomponent toxin encoded by phage that can be inserted into the S. aureus genome (9). This toxin was introduced as one of the CA-MRSA markers, especially in skin and soft tissue infections (10). In Asia, the most prevalent MRSA clone is ST239 that is different from the USA and European clones (11)(12)(13).…”

Association of Virulence Factor (Panton–valentine Leukocidin) With Meca Gene in Staphylococcus Aureus Isolates in Tertiary Care Hospital

“…The occurrence of pvl gene in previous stud ies has been reported from 2% to 35% [27,28]. The pvl positive strains lead to infections with different clinical appearance even in immunocompramised patients lead to necrotic pneumonia, which its mortality can be as much as 75% [29].…”

The role of methicillin-resistant Staphylococcus aureus in skin and soft tissue infections

“…Patients usually do not present significant comorbidities or contacts with healthcare system [15]. CA-MRSA frequently encodes the genes for Panton-Valentine leukocidin and a wide spectrum of other exotoxins, leading to a higher virulence compared with HA-MRSA and resulting in high disease severity and possible tissue necrosis [16]. As compared to HA-MRSA, which tends to be multiresistant, CA-MRSA is usually susceptible to narrow-spectrum non-b-lactams such as fluoroquinolones, clindamycin, trimethoprim-sulfamethoxazole and tetracyclines [16].…”