Can nanotechnology help in the fight against COVID-19?

Palestino, Gabriela; García-Silva, Ileana; González‐Ortega, Omar; Rosales‐Mendoza, Sergio

doi:10.1080/14787210.2020.1776115

Cited by 88 publications

(76 citation statements)

References 73 publications

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“…In theory, general detection techniques may also be applicable. Various diagnostic methods based on gold nanoparticles or carbon nanotubes have been proposed as efficacious approaches for sensing SARSCoV-1 and MERS-CoV and other respiratory viruses ( Nasrollahzadeh et al, 2020 ; Palestino et al, 2020 ; Zhang et al, 2020b ), which can serve as prominent models to guide the development of SARS-CoV-2 biosensors based on MOF. As a potential detection platform for SARS-CoV-2, MOF has the following advantages: (1) MOF can be used as an adsorption and fluorescence quenching platform; (2) MOFs can serve as a simple and effective fluorescence anisotropy amplification platform ( Guo et al, 2015 ); (3) MOF with unique structure can be designed using molecular imprinting technology.…”

Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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Virus severely endangers human life and health, and the detection of viruses is essential for the prevention and treatment of associated diseases. Metal-organic framework (MOF), a novel hybrid porous material which is bridged by the metal clusters and organic linkers, has become a promising biosensor platform for virus detection due to its outstanding properties including high surface area, adjustable pore size, easy modification, etc. However, the MOF-based sensing platforms for virus detection are rarely summarized. This review systematically divided the detection platforms into nucleic acid and immunological (antigen and antibody) detection, and the underlying sensing mechanisms were interpreted. The nucleic acid sensing was discussed based on the properties of MOF (such as metal ion, functional group, geometry structure, size, porosity, stability, etc.), revealing the relationship between the sensing performance and properties of MOF. Moreover, antibodies sensing based on the fluorescence detection and antigens sensing based on molecular imprinting or electrochemical immunoassay were highlighted. Furthermore, the remaining challenges and future development of MOF for virus detection were further discussed and proposed. This review will provide valuable references for the construction of sophisticated sensing platform for the detection of viruses, especially the 2019 coronavirus.

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Section: Discussion and Prospectivementioning

confidence: 99%

Metal-organic frameworks for virus detection

Wang

et al. 2020

Biosensors and Bioelectronics

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“…Using nanopore target sequencing method enables simultaneous detection of SARS-CoV-2 and other viruses implicated in the respiratory tract infections within 6–10 h [ 90 ]. Photonic crystals, Metallic NPs, grapheme, and carbon nanotubes (CNTs) with suitable surface chemistry for bio-conjugation and capable of signal amplification are promising candidates for viral detection [ 91 , 92 ], ( Fig. 3 ).…”

Section: Nanomaterials Against the Covid-19mentioning

confidence: 99%

Nanotheranostics against COVID-19: From multivalent to immune-targeted materials

Hassanzadeh

2020

Journal of Controlled Release

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Destructive impacts of COVID-19 pandemic worldwide necessitates taking more appropriate measures for mitigating virus spread and development of the effective theranostic agents. In general, high heterogeneity of viruses is a major challenging issue towards the development of effective antiviral agents. Regarding the coronavirus, its high mutation rates can negatively affect virus detection process or the efficiency of drugs and vaccines in development or induce drug resistance. Bioengineered nanomaterials with suitable physicochemical characteristics for site-specific therapeutic delivery, highly-sensitive nanobiosensors for detection of very low virus concentration, and real-time protections using the nanorobots can provide roadmaps towards the imminent breakthroughs in theranostics of a variety of diseases including the COVID-19. Besides revolutionizing the classical disinfection procedures, state-of-the-art nanotechnology-based approaches enable providing the analytical tools for accelerated monitoring of coronavirus and associated biomarkers or drug delivery towards the pulmonary system or other affected organs. Multivalent nanomaterials capable of interaction with multivalent pathogens including the viruses could be suitable candidates for viral detection and prevention of further infections. Besides the inactivation or destruction of the virus, functionalized nanoparticles capable of modulating patient’s immune response might be of great significance for attenuating the exaggerated inflammatory reactions or development of the effective nanovaccines and medications against the virus pandemics including the COVID-19.

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“…Hyperbranched, monodispersed, easily biodegradable organic dendrimers have gained importance for more than a decade in the field of nanomedicine because they act as targeted carriers for biological systems. The antiviral activity of dendrimers is still under scientific investigations, which may be facilitated through conjugated drug delivery mechanisms ( Patil et al (2020) ; Palestino et al (2020) ). The efficacy of such nanoparticulated dendrimer system can be observed for the inhibition of HSV-1/influenza virus, where antibody mediated response/CD8 + T cell activation and regulation of gene expressions are achieved through small RNAs inactivation ( Shang et al, 2020 ; Sportelli et al, 2020 ).…”

Section: Mode Of Action and Biomedical Applications Of Biocompatible mentioning

confidence: 99%

Biomedical application, drug delivery and metabolic pathway of antiviral nanotherapeutics for combating viral pandemic: A review

Mukherjee

Mazumder

Joshi

et al. 2020

Environmental Research

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a neoteric virus belonging to the beta coronavirus class has created a global health concern, responsible for an outbreak of severe acute respiratory illness, the COVID-19 pandemic. Infected hosts exhibit diverse clinical features, ranging from asymptomatic to severe symptoms in their genital organs, respiratory, digestive, and circulatory systems. Considering the high transmissibility (R 0 : ≤6.0) compared to Middle East respiratory syndrome coronavirus (MERS-CoV) and SARS-CoV, the quest for the clinical development of suitable antiviral nanotherapeutics (NTPs) is incessant. We are presenting a systematic review of the literature published between 2003 and 2020 to validate the hypothesis that the pharmacokinetics, collateral acute/chronic side effects of nano drugs and spike proteins arrangement of coronaviruses can revolutionize the therapeutic approach to cure COVID-19. Our aim is also to critically assess the slow release kinetics and specific target site chemical synthesis influenced competence of NTPs and nanotoxicity based antiviral actions, which are commonly exploited in the synthesis of modulated nanomedicines. The pathogenesis of novel virulent pathogens at the cellular and molecular levels are also considered, which is of utmost importance to characterize the emerging nano-drug agents as diagnostics or therapeutics or viral entry inhibitors. Such types of approaches trigger the scientists and policymakers in the development of a conceptual framework of nano-biotechnology by linking nanoscience and virology to present a smart molecular diagnosis/treatment for pandemic viral infections.

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Can nanotechnology help in the fight against COVID-19?

Cited by 88 publications

References 73 publications

Metal-organic frameworks for virus detection

Metal-organic frameworks for virus detection

Nanotheranostics against COVID-19: From multivalent to immune-targeted materials

Biomedical application, drug delivery and metabolic pathway of antiviral nanotherapeutics for combating viral pandemic: A review

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