Abstract:Isoquinoline alkaloids have multiple biological activities, which might be associated with positive pharmacological effects as well as negative adverse reactions. As bleeding was suggested to be a side effect of the isoquinoline alkaloid berberine, we decided to ascertain if different isoquinoline alkaloids could influence hemocoagulation through the inhibition of either platelet aggregation or blood coagulation. Initially, a total of 14 compounds were screened for antiplatelet activity in whole human blood by… Show more
“… 52 Various oxidized lipids derived from the ω-6 arachidonic acid have the potential to increase platelet aggregation. 53 Alterations in oxylipin levels correlate with platelet counts, indicating a robust connection between inflammation and platelet aggregation in alcohol use disorders and AH. 54 …”
“… 52 Various oxidized lipids derived from the ω-6 arachidonic acid have the potential to increase platelet aggregation. 53 Alterations in oxylipin levels correlate with platelet counts, indicating a robust connection between inflammation and platelet aggregation in alcohol use disorders and AH. 54 …”
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