Biologically active isoquinoline alkaloids covering 2019–2022

Wang, Dengtuo; Qin, Lulu; Jing, Chenxin; Wang, Guanghan; Zhou, Han; Deng, Peng; Zhang, Shaoyong; Wang, Yirong; Ding, Yanyan; Zhang, Zhijun; Wu, Zhengrong; Liu, Yingqian

doi:10.1016/j.bioorg.2024.107252

Bioorganic Chemistry

2024

DOI: 10.1016/j.bioorg.2024.107252

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Biologically active isoquinoline alkaloids covering 2019–2022

Dengtuo Wang,

Lulu Qin,

Chenxin Jing

et al.

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2024

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Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

Milusheva,

Stoyanova,

Gledacheva

et al. 2024

Biomedicines

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This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption and the ability to cross the blood–brain barrier, which is a very important parameter in the drug discovery processes. In silico simulation predicted smooth muscle relaxant activity for all the compounds. Since smooth muscle contractile failure is a characteristic feature of many disorders, in the current paper, we concentrate on the parameters of the spontaneous contractile responses of smooth muscle (SM) cells compared to the well-known drug mebeverine. Two of the newly synthesized substances can be identified as essential modulating regulators and potentially used as therapeutic molecules. One of these molecules also showed significant DPPH antioxidant activity compared to rutin.

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Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

Milusheva,

Stoyanova,

Gledacheva

et al. 2024

Biomedicines

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show abstract

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Biologically active isoquinoline alkaloids covering 2019–2022

Cited by 1 publication

References 451 publications

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines

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