Can highly purified collagen coating modulate polypropylene mesh immune-inflammatory and fibroblastic reactions? Immunohistochemical analysis in a rat model

Dias, Fernando Goulart Fernandes; Prudente, Alessandro; Siniscalchi, Rodrigo Teixeira; Vidal, Benedicto de Campos; Riccetto, Cássio

doi:10.1007/s00192-014-2529-0

Cited by 15 publications

(7 citation statements)

References 25 publications

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“…However, Dias et al . reported a decrease in the average density of MMP-2 expression in the collagen-coated polypropylene mesh after 90 days and there was no significant difference in the immunological response (IL-1) and tissue necrosis/apoptosis (TNF-α)17 in contrast with our findings. This aspect of collagen-coated mesh needs to be looked into as the effect of prolonged inflammatory reaction in this type of mesh is still not clear.…”

Section: Discussioncontrasting

confidence: 97%

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Lin

Yusoff

et al. 2016

Sci Rep

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Our aim is to study the inflammatory response towards the collagen-coated and non-coated polypropylene meshes in rats and the urodynamic investigation post-operatively. Forty-two female Sprague Dawley were divided into 7 groups of 6 rats; Control, Day 7 and 30 for Sham, Avaulta Plus (MPC), Perigee (MP). UDS were taken at days 7 and 30. Mesh with the vagina and bladder wall was removed and sent for immunohistochemical examination. Results showed intense inflammatory reaction on day 7 in the study groups which decreased on day 30. IL-1, TNF-α, MMP-2 and CD31 were observed to decrease from day 7 to day 30. NGF was almost normal on day 30 in all groups. UDS showed no difference in voiding pressure. Both Study and Sham groups had shorter voiding interval (VI) on day 7 but significantly lower in MPC. VI had significantly increased on day 30 in all groups. Voided volume was significantly lower in the mesh groups even when an increase was seen on day 30. In conclusion, the higher levels of IL-1, TNF-α and MMP-2 in collagen-coated polypropylene mesh imply greater inflammation than the non-coated polypropylene mesh. Mesh implantation can lead to shorter voiding interval and smaller bladder capacity.

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Section: Discussioncontrasting

confidence: 97%

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Lin

Yusoff

et al. 2016

Sci Rep

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“…The host's reaction to the implant is related to the type of material used; for example, an autologous fascia promotes lower inflammation and produces less collagen ( 7 ). Various protocols tested bioactive substances that act on inflammation and accelerate the repair process ( 8 , 9 ). However, the complexity of the implant-host interaction impedes their use and causes controversy.…”

Section: Introductionmentioning

confidence: 99%

Histological response to platelet-rich plasma added to polypropylene mesh implemented in rabbits

et al. 2016

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Introduction:The platelet-rich plasma (PRP) is part of a set of biotechnologies, providing some growth factors that promote repair of different tissues. The polypropylene meshes (PPM) are applied in the correction of abdominal defects, pelvic floor and urinary incontinence, however, they induce many significant complications, as a result of an inappropriate inflammatory response.Purpose:To investigate the changes caused by PRP associated with the implantation of PPM in the abdomen of female rabbits, in the production of collagen I and III and the inflammatory infiltrate (ININ).Materials and Methods:We performed implant meshes with and without PRP in adult rabbits (n=30) and euthanasia at 7, 30 and 90 days. Two plates were prepared from each animal and analyzed in five different fields. The ININ was evaluated by quantification of inflammatory cells using hematoxylin-eosin and the collagen by Sirius red method. The results were analyzed applying the Wilcoxon, Kruskal-Wallis, Junckheere and Friedmann tests.Results:There was a significant difference in the number of inflammatory cells between the groups with and without PRP (p=0.01) at 90 days. There was increased production of collagen I, III and total with the use of PRP, at seven days.Conclusion:The PPM coating with PRP was associated with increased ININ at the implant area, and an increasing trend during the process of tissue repair. The PPM coated with PRP was related to increased concentration of collagen I, collagen III and the concentration of total collagen increased after seven days of implantation.

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“…There was a higher vessel density compared to simple polypropylene meshes, more stability of MMP-3 with the decrease of MMP-3 after 14 and 90 days and a decrease in average density of MMP-3 after 21 days in the simple polypropylene meshes and after 90 days in the polypropylene meshes covered with collagen. This can improve the mesh biocompatibility for pelvic floor surgery 39 .…”

Section: Polypropylene Meshes and Polypropylene Covered With Collagenmentioning

confidence: 99%

Polypropylene meshes and other alloplastic implants for soft tissue and cartilage nasal reconstructive surgery – a literature review

Ionita

Popescu

Lascăr

2015

Romanian Journal of Rhinology

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Can highly purified collagen coating modulate polypropylene mesh immune-inflammatory and fibroblastic reactions? Immunohistochemical analysis in a rat model

Abstract: Highly purified collagen coating causes significant changes in angiogenesis and in the immune reaction of metalloproteinase around mesh implants in rats. These findings can be useful for improving mesh biocompatibility for pelvic floor surgery if such effects could be properly controlled.

Cited by 15 publications

References 25 publications

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

The immunohistochemical and urodynamic evaluation towards the collagen-coated and non-coated polypropylene meshes implanted in the pelvic wall of the rats

Histological response to platelet-rich plasma added to polypropylene mesh implemented in rabbits

Polypropylene meshes and other alloplastic implants for soft tissue and cartilage nasal reconstructive surgery – a literature review

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