Can hamartoma of the breast be distinguished from fibroadenoma using fine‐needle aspiration cytology?

Herbert, Mehrdad; Mendlovic, Sonia; Liokumovich, Pavel; Segal, Michael; Zahavi, S.; Rath‐Wolfson, Lea; Sandbank, Judith

doi:10.1002/dc.20404

Cited by 18 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of a well-circumscribed breast lesion with intact lobular units admixed with various amounts of adipose tissue and a relative paucity of stroma in aspirate form may support the diagnosis of hamartoma pathologically (14). This feature is also useful to differentiate the tumor from a fibroadenoma, with which it may share a clinical and histological resemblance (15).…”

Section: Discussionmentioning

confidence: 99%

Giant breast hamartoma in a 41-year-old female: A case report and literature review

Wang

2015

Oncology Letters

View full text Add to dashboard Cite

Abstract. Breast hamartoma is an uncommonly reported benign breast lesion of uncertain cause and pathogenesis. The diagnosis of breast hamartoma by a single method such as mammography, magnetic resonance imaging or sonography is inadequate. In the majority of cases, the breast hamartoma is excised a few years after it has occurred when it is not too big. In the present report, however, a particularly large lesion with a long history is described. Such a case has rarely been reported and shows the necessity of early surgery to reduce trauma as much as possible. Excision of hamartoma was successfully performed and an 11x9x3.5-cm tumor was completely excised. The present study also reviews the literature on breast hamartoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Giant breast hamartoma in a 41-year-old female: A case report and literature review

Wang

2015

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Therefore, it is important to stress the adequacy of tissue sampling and correlation with radiographic and clinical findings when making a diagnosis of hamartoma without surgical excision. The pathologic findings of disorganized lobules and varying amounts of adipose tissue on a core needle biopsy of a clinically palpable and radiologically evident mass suggests the diagnosis of hamartoma, particularly if a discrete boundary between the lesion and normal tissue is appreciable (6,13). The histologic findings are distinct from those of fibroadenoma, which is characterized by a proliferation of specialized, intralobular stroma and an intracanalicular or pericanalicular ductular pattern; lobules and fat are typically absent (14).…”

Section: Discussionmentioning

confidence: 99%

Breast Hamartomas in Adolescent Females

2009

View full text Add to dashboard Cite

Breast hamartomas are uncommon lesions that have not been extensively characterized in the adolescent population. A search of patient records at our institution over a 17-year period identified seven cases of breast hamartomas in patients less than 18 years of age. We examine and report the clinical, radiographic, and pathologic characteristics of these cases. Breast hamartomas present as painless, palpable masses in the adolescent population. Ultrasonography reveals a well-defined, solid, oval mass, similar to the more common fibroadenoma. Two of the patients underwent core needle biopsy for diagnosis as the only intervention with the remainder undergoing surgical excision. None of the patients had any complications from surgery. There was one recurrence 9 months after initial excision. Histologically, the hamartomas consisted of densely packed, enlarged lobules set within a fibrous stroma. Breast hamartomas are rare in the adolescent population. The clinical and radiographic features are similar to the more common fibroadenoma, but the pathologic findings are diagnostic. Recurrence can occur if excision is incomplete. Increased recognition and accurate diagnosis will improve our understanding of the natural history of these lesions.

show abstract

“…Important cytologic findings include the presence of intact lobular units, abundant adipose tissue, and paucity of stroma; all considered as clues to the diagnosis. [32][33][34] Most FNAC cases are signed out in a benign descriptive fashion.…”

Section: Cytologic Differential Diagnosismentioning

confidence: 99%

“…The paucity of stromal fragments, the presence of adipose tissue, and intact round lobular units may be helpful features favoring hamartoma over fibroadenoma. [32][33][34]…”

Section: Cytologic Differential Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

Mammary mesenchymal and fibroepithelial lesions: An illustrated cytomorphologic update with differential diagnoses

Khattab

Rowe

Booth

et al. 2019

Diagnostic Cytopathology

View full text Add to dashboard Cite

The Uniform Approach to Breast Fine Needle Aspiration Biopsy was put forward by a learned group of breast physicians in 1997. This landmark manuscript focused predominantly on diagnosis and reporting of mammary epithelial lesions. Today, most American practitioners turn initially to core biopsy rather than aspiration biopsy for the first line diagnosis of solid breast lesions; however, recent efforts from the International Academy of Cytology have produced a system called the Standardized Reporting of Breast Fine Needle Aspiration Biopsy Cytology (colloquially labeled in 2017 as the “Yokohama System”), suggesting a new interest in breast fine needle aspiration (FNA), especially in resource limited settings or clinical practice settings with experienced breast cytopathologists. Fibroepithelial lesions of the breast comprise a heterogeneous group of biphasic tumors with epithelial and stromal elements. Mesenchymal lesions of the breast include a variety of neoplasms of fibroblastic, myofibroblastic, endothelial, neural, adipocytic, muscular, and osteo‐cartilaginous derivations. The cytology of mesenchymal breast lesions is infrequently described in the literature and is mainly limited to case reports and small series. This illustrated review highlights the cytologic features of fibroepithelial and mesenchymal mammary proliferations and discusses differential diagnoses and histomorphologic correlates.

show abstract

Can hamartoma of the breast be distinguished from fibroadenoma using fine‐needle aspiration cytology?

Cited by 18 publications

References 12 publications

Giant breast hamartoma in a 41-year-old female: A case report and literature review

Giant breast hamartoma in a 41-year-old female: A case report and literature review

Breast Hamartomas in Adolescent Females

Mammary mesenchymal and fibroepithelial lesions: An illustrated cytomorphologic update with differential diagnoses

Contact Info

Product

Resources

About