Can follicular Emmprin and BMP 4 levels predict ICSI outcome?

Takmaz, Özgüç; Yozgatli, Dilara; Ozaltin, Selin; Ozbasli, Esra; Kocyigit, Yucel; Kuran, Sibel Bulgurcuoğlu; Bulut, Huri; Güngör, Mete; Buyru, Faruk; Baştu, Ercan

doi:10.1007/s10815-019-01459-0

Cited by 3 publications

(2 citation statements)

References 29 publications

(46 reference statements)

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“…In addition, BSG gene expression has been shown to cause mouse infertility with an abnormal fertilization process and impaired embryo implantation [ 10 ]. Moreover, it was found that the concentration of BSG protein in the follicular fluid is associated with clinical pregnancy rate in patients undergoing in vitro fertilization, more specifically intracytoplasmic sperm injection (ICSI); at lower concentrations of this protein, the clinical pregnancy rate was higher, therefore, this protein was proposed as a marker for predicting ICSI outcomes [ 41 ]. Taking these functions into account, SARS-CoV-2 might disturb the female reproductive functions through regulating the ACE2 and BSG gene expression.…”

Section: Discussionmentioning

confidence: 99%

Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?

Virant‐Klun

Strle

2021

Stem Cell Rev and Rep

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Section: Discussionmentioning

confidence: 99%

Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?

Virant‐Klun

Strle

2021

Stem Cell Rev and Rep

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“…The discovery of these proteins was due to their ability to induce bone and cartilage formation. BMPs are now thought of as a group of axial morphogenic messengers that harmonize tissue architecture throughout the body (47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

The effect of cellular and physiological indicators on gender determination

Haje

2021

Cell Mol Biol (Noisy-le-grand)

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Gender determination, in addition to having special value to parents, has particular importance in sex-linked diseases. This study aimed to investigate the cellular indicators (i.e. BMP-6 protein and PPAR? protein expression levels in granulosa cells) and the physiological indicators on gender determination. For this purpose, on 68 infertile patients referred to the clinic, ovarian stimulation was performed by different protocols and then ruptured by different HCG. Follow-up of patients was performed after they became pregnant after five months. U/S was done for knowing the gender of the baby then after labor rechecked another time. Also, granulosa-luteal cells (GLCs) were isolated from the follicular fluid of 68 women participating in the study. BMP-6 protein and PPAR? protein were measured using Western blotting. Results showed that the total number of delivered babies was 68, 41 males (60.3%) and 27 females (39.7%). About physiological indicators results, there was no significant association between the age of the mother and sex of the baby (P=0.934). No significant association was detected between the month during which the conception occurred and the sex of the baby (P=0.734). The same result was obtained for the follicle side (P=0.236), and follicle size (P=0.659), there was no significant association between the sex of the baby with the following factors: protocol of treatment (P=0.417), IVF after HCG (P=0.237), HCG type (P=0.572), parity (P=0.282), and type of infertility (P=0.376). The cellular indicators results showed that the BMP-6 protein level in granulosa cells of mothers with daughters was almost twice as high as mothers with sons (P=0.043). But there was no significant difference between mothers with daughters and mothers with sons in PPAR? protein level (P=0.12). It can be concluded that except for BMP-6 protein level, none of the cellular and physiological indicators affects gender determination. Therefore, this cell indicator can probably be evaluated as an effective indicator in determining gender.

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The Roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in Folliculogenesis and In Vitro Fertilization

Fountas,

Petinaki,

Bolaris

et al. 2024

JCM

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Growth differentiation factor 9 (GDF-9) contributes to early ovarian development and oocyte survival. Higher concentrations of GDF-9 in follicular fluid (FF) are associated with oocyte nuclear maturation and optimal embryo development. In in vitro fertilization (IVF), GDF-9 affects the ability of the oocyte to fertilize and subsequent embryonic development. Bone morphogenetic protein 15 (BMP-15) is involved in the regulation of ovarian function and affects oocyte development. During IVF, BMP-15 contributes to the formation of competent blastocysts. BMP-15 may play a role in embryo implantation by affecting endometrial receptivity. Bone morphogenetic protein 4 (BMP-4) is involved in the regulation of follicle growth and development and affects granulosa cell (GC) differentiation. In relation to IVF, BMP-4 is important for embryonic development, influences cell fate and differentiation, and plays a role in facilitating embryo–endometrial interactions during the implantation process. Extracellular matrix metalloproteinase inducer (EMMPRIN) is associated with ovulation and follicle rupture, promotes the release of mature eggs, and affects the modification of the extracellular matrix of the follicular environment. In IVF, EMMPRIN is involved in embryo implantation by modulating the adhesive properties of endometrial cells and promotes trophoblastic invasion, which is essential for pregnancy to occur. The purpose of the current article is to review the studies and recent findings of GDF-9, BMP-15, BMP-4 and EMMPRIN as fundamental factors in normal follicular development and in vitro fertilization.

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Can follicular Emmprin and BMP 4 levels predict ICSI outcome?

Cited by 3 publications

References 29 publications

Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?

Human Oocytes Express Both ACE2 and BSG Genes and Corresponding Proteins: Is SARS-CoV-2 Infection Possible?

The effect of cellular and physiological indicators on gender determination

The Roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in Folliculogenesis and In Vitro Fertilization

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