Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Samaro, Aseel; Shaqour, Bahaa; Goudarzi, Niloofar Moazami; Ghijs, Michaël; Cardon, Ludwig; Boone, Matthieu; Verleije, Bart; Beyers, Koen; Vanhoorne, Valérie; Cos, Paul

doi:10.1016/j.ijpharm.2021.120922

Cited by 30 publications

(36 citation statements)

References 39 publications

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“…PCL melting point can be reached at around 60 °C; however, the melt viscosity may vary with and without HA and HNT. This has a direct impact both on the HME and 3D printing process [ 16 , 26 , 27 ]. During HME, there was no large variation in the extrusion temperature (around 10 °C change) because of the relatively large extrusion die.…”

Section: Discussionmentioning

confidence: 99%

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3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice

et al. 2022

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Bacterial infections are a serious healthcare complication in orthopedic and trauma surgery worldwide. Compared to systemic, local antibiotic prophylaxis has been shown to provide a higher antibiotic dose and bioavailability at the bone site with minimum toxic effects. However, there are still not enough biomaterial and antibiotic combinations available for personalized implant sizes for patients. The aim of this study was to develop a bone fixation plate coating made of a composite of poly-ε-caprolactone, hydroxyapatite and halloysite nanotubes loaded with gentamicin sulphate and fabricated via fused filament fabrication 3D printing technology. The mechanical and thermal properties of the biomaterial were analyzed. The in vitro release kinetics of gentamicin sulphate were evaluated for 14 days showing a burst release during the first two days that was followed by a sustained release of bactericidal concentrations. The composite loaded with 2 and 5% gentamicin sulphate exhibited complete antimicrobial killing of Staphylococcus aureus in an ex vivo mouse femur fixation plate infection model. Moreover, a fixation plate of the composite loaded with 5% of gentamicin sulphate was able to prevent S. aureus infection in the bone and surrounding tissue in an in vivo mouse bone fixation plate infection model 3 days post-surgery. In conclusion, the newly developed composite material successfully prevented infection in vivo. Additionally, the ability to use fused filament fabrication 3D printing to produce patient-specific implants may provide a wider range of personalized solutions for patients.

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Section: Discussionmentioning

confidence: 99%

“…The mechanical properties of the produced filaments were tested using tensile and three-point bending tests ( n = 5) [ 16 ]. A texture analyzer (TA.HDplusC, Stable Micro Systems, Surrey, UK) equipped with a 50 kg load cell was used.…”

Section: Methodsmentioning

confidence: 99%

3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice

et al. 2022

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“…[48,49] Moreover, several prototype printers with screwbased extrusion systems have been explored for the pharmaceutical and food engineering fields. [50][51][52][53] Thus, the development of a novel 3D printing strategy based on the screw extrusion device is expected to overcome the problem that only high-modulus magnetic materials can be printed by the FDM in previous studies.…”

Section: Introductionmentioning

confidence: 99%

3D Printing Ultraflexible Magnetic Actuators via Screw Extrusion Method

et al. 2022

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Soft magnetic actuators with programmable structure design and controllable deformation ability based on 3D printing technology have attracted extensive attention. In this paper, a novel 3D printing strategy is developed to manufacture the ultraflexible magnetic actuator, in which the printed material is composed of magnetic particles and thermoplastic rubber materials. Different from the traditional fused deposition printing, this printing strategy introduces screw extrusion technology to the heating components of the printer to overcome the problem of filament buckling in the flexible material. Thus, the tensile modulus of the printed products can be reduced to as low as ≈2 MPa. Based on the above method, biomimetic magnetic actuators of the sucker and the pump are constructed for adhering and releasing object and pumping liquid. The contraction performance of the magnetic actuator is studied via a series of experiments and the magnetic field-induced deformation is analyzed by the multiphysics-based finite element model. This work proves that ultraflexible magnetic actuators fabricated by this 3D printing strategy show broad prospects in the fields of soft robotics and bionics.

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“…In PBAM, polymers in the form of granules instead of filaments are fed in small single-screw extruders (SSEs) to allow for material deposition and solidification. 1,2,[13][14][15][16][17][18][19][20][21] Such extrusion-based AM (EAM) overcomes limitations of filament-based AM, allowing applications for soft and brittle polymers that can be more challenging to 3D print. 22,23 The cost of the pellet feedstock material is also lower compared to the filament counterpart 23 and EAM allows to bypass the filament production extrusion process so that less degradation of the material is expected.…”

Section: Introductionmentioning

confidence: 99%

Comparing pellet‐ and filament‐based additive manufacturing with conventional processing for ABS and PLA parts

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et al. 2022

J of Applied Polymer Sci

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More recently pellet‐based additive manufacturing or so‐called micro‐extrusion has become more popular for final polymeric part production. In the present work, it is evaluated how pellet‐based AM (PBAM) performs for its extrudates and specimens compared to the more established fused filament fabrication technique, considering both commercial acrylonitrile butadiene styrene polymer and poly(lactic acid) pellets and filaments as feedstocks. For benchmarking purposes, a comparison with conventional techniques, that is, single screw extrusion and injection molding, is also included. To support the performance interpretation a theoretical analysis is conducted regarding the melting finalization point as well as void measurements and Fourier transfer infrared spectroscopic analysis for degradation effects are included. It is demonstrated that for the extrudates comparable results are obtained among the different manufacturing techniques, whereas for the specimens the situation is dissimilar. It is highlighted that PBAM/ME has a large market potential implementation, provided that its operating settings are further optimized.

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Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Cited by 30 publications

References 39 publications

3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice

3D-Printed Gentamicin-Releasing Poly-ε-Caprolactone Composite Prevents Fracture-Related Staphylococcus aureus Infection in Mice

3D Printing Ultraflexible Magnetic Actuators via Screw Extrusion Method

Comparing pellet‐ and filament‐based additive manufacturing with conventional processing for ABS and PLA parts

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