Can antioxidants supplementation improve ICSI/IVF outcomes in women undergoing IVF/ICSI treatment cycles? Randomised controlled study

Aboulfoutouh, Ismail; Youssef, Mohamed; Khattab, S.

doi:10.1016/j.fertnstert.2011.07.928

Cited by 4 publications

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“…The importance of this issue is determined by the fact that the age of childbearing has been postponed to the fourth decade of life in the modern societies [34]. As a result of declined fertility, such women will have more need to assisted reproductive techniques (ART) to have children [5]. ART, in turn, has high cost and more complications in advanced maternal age which is undesired [67].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, useful effects of vitamin C on metabolism, collagen synthesis, vasculogenesis, aging, cell proliferation, and differentiation has been reported previously [21222324]. Although, so far, several studies have investigated the role of vitamin C in combination with other antioxidants on female infertility [51925], there are scarcely data regarding to the effect of vitamin C alone on ovarian aging. In the present study, we aimed to evaluate the effects of vitamin C on NMRI mice ovarian aging according to the stereological study.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin C restores ovarian follicular reservation in a mouse model of aging

et al. 2019

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Ovarian aging is related to the reduction of oocyte quality and ovarian follicles reservation leading to infertility. Vitamin C is a natural antioxidant which may counteract with adverse effects of aging in the ovary. The aim of this study was to evaluate the possible effect of vitamin C on NMRI mice ovarian aging according to the stereological study. In this experimental study, 36 adult female mice (25–30 g) were divided into two groups: control and vitamin C. Vitamin C (150 mg/kg/day) were administered by oral gavage for 33 weeks. Six animals of each group were sacrificed on week 8, 12, and 33, and right ovary samples were extracted for stereology analysis. Our data showed that the total volume of ovary, cortex, medulla and corpus luteum were significantly increased in vitamin C group in comparison to the control groups ( P ≤0.05). In addition, the total number of primordial, primary, secondary, and antral follicles as well as granulosa cells were improved in vitamin C group in compared to the control groups ( P ≤0.05). No significant difference was observed in total volume of oocytes in antral follicles between control and vitamin C groups. Our data showed that vitamin C could notably compensate undesirable effects of ovarian aging in a mouse model.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin C restores ovarian follicular reservation in a mouse model of aging

et al. 2019

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2013

Cochrane Database of Systematic Reviews

117

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Antioxidants for female subfertility

Showell

Mackenzie‐Proctor

Jordan

et al. 2017

Cochrane Database of Systematic Reviews

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Background A couple may be considered to have fertility problems if they have been trying to conceive for over a year with no success. This may affect up to a quarter of all couples planning a child. It is estimated that for 40% to 50% of couples, subfertility may result from factors affecting women. Antioxidants are thought to reduce the oxidative stress brought on by these conditions. Currently, limited evidence suggests that antioxidants improve fertility, and trials have explored this area with varied results. This review assesses the evidence for the effectiveness of different antioxidants in female subfertility. Objectives To determine whether supplementary oral antioxidants compared with placebo, no treatment/standard treatment or another antioxidant improve fertility outcomes for subfertile women. Search methods We searched the following databases (from their inception to September 2016) with no language or date restriction: Cochrane Gynaecology and Fertility Group (CGFG) specialised register, the Cochrane Central Register of Studies (CENTRAL CRSO), MEDLINE, Embase, PsycINFO, CINAHL and AMED. We checked reference lists of appropriate studies and searched for ongoing trials in the clinical trials registers. Selection criteria We included randomised controlled trials (RCTs) that compared any type, dose or combination of oral antioxidant supplement with placebo, no treatment or treatment with another antioxidant, among women attending a reproductive clinic. We excluded trials comparing antioxidants with fertility drugs alone and trials that only included fertile women attending a fertility clinic because of male partner infertility. Data collection and analysis Two review authors independently selected eligible studies, extracted the data and assessed the risk of bias of the included studies. The primary review outcome was live birth; secondary outcomes included clinical pregnancy rates and adverse events. We pooled studies using a fixed-effect model, and calculated odds ratios (ORs) with 95% confidence intervals (CIs) for the dichotomous outcomes of live birth, clinical pregnancy and adverse events. We assessed the overall quality of the evidence by applying GRADE criteria.

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Can antioxidants supplementation improve ICSI/IVF outcomes in women undergoing IVF/ICSI treatment cycles? Randomised controlled study

Cited by 4 publications

References 0 publications

Vitamin C restores ovarian follicular reservation in a mouse model of aging

Vitamin C restores ovarian follicular reservation in a mouse model of aging

Antioxidants for female subfertility

Antioxidants for female subfertility

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