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CRD42016041301.

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Background: The aim of this study was to determine whether the treatment with doxycycline before and after oocyte retrieval is as effective as salpingectomy in minimizing the detrimental effect of hydrosalpinx on the outcomes of IVF-ET. Methods: A retrospective analysis was done for the outcomes of the IVF-ET cycles of patients with hydrosalpinx who underwent laparoscopic salpingectomy prior to IVF cycle (n = 260) or were treated with extended doxycycline treatment during the IVF cycle (n = 45). In doxycycline group, doxycycline (100 mg twice daily) was started 1 week before anticipated oocyte retrieval and was continued for 1 week after oocyte retrieval. In salpingectomy group, the mesosalpinx was coagulated as close as possible to the fallopian tube. Results: The implantation, clinical pregnancy, ongoing pregnancy and live birth rates were significantly higher in the salpingectomy group (20.87% Vs. 9.91%, P value =0.007, 44.62% Vs. 20%, P value = 0.002, 39.62% Vs. 17.78%, P value = 0.005 and 37.31% Vs. 15.56%, P value = 0.005 respectively). Conclusion: Salpingectomy is more effective than extended doxycycline treatment in improving the outcomes of IVF-ET in patients with hydrosalpinx undergoing IVF-ET. Further, larger well designed randomized controlled trials should be conducted to confirm the findings of this study.

In this review, a systematic meta-analysis on randomized controlled trials that evaluate the effectiveness of supplementation of chelated zinc (Zn) on milk production in dairy cow has been performed. A total of 2106 transition dairy cows belonging to 23 studies from 7 papers were finally selected (treated, n = 1053; control, n = 1053). A meta-analysis of the effect of chelated Zn on milk production in dairy cow during lactation period was conducted following a search of literature. The data of cows either treated or controlled were extracted and analyzed by using comprehensive meta-analysis software program. I 2 statistic was used to estimate the degree of heterogeneity. Forest plot was used to present the means and their confidence intervals in a graphic manner and heterogeneous degree were explored with meta-regression; also, Begg’s test was conducted to investigate the publication bias. Overall, trial analysis of trials revealed that there was no significant effect of chelated Zn on milk production based on effect size (ES) and the confidence interval (95% CI) in comparison with the control cows (milk production ES = (0.941–1.183) 1.057, p value =0.337). A forest plot for the impact of chelated Zn on milk production was presented. The forest plots indicated that there is no heterogeneity between treated and control cows in response to supplementation of chelated Zn on milk production. The results of Begg’s test for publication bias were not significant. In conclusion, chelated Zn supplementation among dairy cows during lactation period provided a non-significant impact on milk yield.

Background Myopia is the most prevalent form of refractive error that has a major negative impact on visual function and causes blurring of vision. We aimed to determine if Repeated Low-Level Red Light (RLRL) treatment is beneficial in treating childhood myopia in terms of axial length (AL), spherical equivalent refraction (SER), and sub foveal choroidal thickness (SFCT).Methods This systematic review was performed on RLRL for treatment of myopia in Children compared to singe vision spectacles (SVS). We employed the search strategy with key terms myopia and low-level light therapy then we searched PubMed, Scopus, Cochrane, and Web of Science databases. The mean differences (MD) were used to evaluate the treatment effects. Heterogeneity was quantified using I2 statistics and explored by sensitivity analysis.Results Five randomized controlled trials (RCTs) were included in our meta-analysis with a total of 833 patients, 407 in treatment group and 426 in control group. At a 3 month follow up period, pooled studies show a statistical difference in AL between RLRL and SVS group (MD = -0.16; 95% CI [-0.19, -0.12], SER (MD = 0.33; 95% CI [0.27, 0.38]), and SFCT (MD = 43.65; 95% CI [23.72, 45.58]). At a 6 month follow up period, pooled studies show a statistical difference in AL between RLRL and SVS group (MD = -0.21; 95% CI [-0.28, -0.15]), SER (MD = 0.46; 95% CI [0.26, 0.65]), and SFCT (MD = 25.07; 95% CI [18.18, 31.95]). At a 12 month follow up period, pooled studies show a statistical difference in AL between RLRL and SVS group (MD = -0.31; 95% CI [-0.42, -0.19]) and SER (MD = 0.63; 95% CI [0.52, 0.73]).Conclusion This is the first systematic review and meta-analysis investigating evidence supporting the efficacy of 650 nm RLRL for myopia control in the short term of 3, 6, and 12 months follow up. The present review revealed the clinical significance of RLRL as a new alternative treatment for myopia control with good user acceptability and no documented functional or structural damage. However, the effect of long-term RLRL treatment and the rebound effect after cessation require further investigation.

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