Can 4D bioprinting revolutionize drug development?

Lukin, Izeia; Musquiz, Saioa; Erezuma, Itsasne; Al‐Tel, Taleb H.; Golafshan, Nasim; Dolatshahi-Pirouz, Alireza; Orive, Gorka

doi:10.1080/17460441.2019.1636781

Cited by 25 publications

(13 citation statements)

References 26 publications

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“…A considerable number of publications, especially review papers, are focused at the fundamental aspects of 3D bioprinting, and are included within the class of process-driven papers. For instance, a basic theme such as biomimicry shows steady growth from 2010, while there are newer ideas, including four-dimensional (4D) bioprinting that first appeared in 2016 and is already the subject of 28 papers [33][34][35][36][37][38][39][40][41]. Some publications show the bioprinting workflow [27][28][29] and areas [42], while the ethical aspects of bioprinting are still relatively underrepresented [43].…”

Section: Bioprinting Research Landscape: Main Applications and Emerging Topicsmentioning

confidence: 99%

3D bioprinting: current status and trends—a guide to the literature and industrial practice

et al. 2021

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The multidisciplinary research field of bioprinting combines additive manufacturing, biology and material sciences to create bioconstructs with three-dimensional architectures mimicking natural living tissues. The high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine, thus allowing bioprinting to establish itself in the field of biomedical research, and attracting extensive research efforts from companies, universities, and research institutes alike. In this context, this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex position. The scientific literature and patenting results for 2000–2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries, institutions, journals, authors and topics, and identifying the technology hubs worldwide. This review paper thus offers a guide to researchers interested in this field or to those who simply want to understand the emerging trends in additive manufacturing and 3D bioprinting. Graphic abstract

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Section: Bioprinting Research Landscape: Main Applications and Emerging Topicsmentioning

confidence: 99%

3D bioprinting: current status and trends—a guide to the literature and industrial practice

et al. 2021

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“…Considering SMPs processing into the original shape, the advent of 3D printing technologies has further widened the range of applications of these materials by providing the tool for 4D printing [79 [80][81][82][83][84][85]. This term was used for the first time in 2013 by Tibbits during a TED talk to highlight time as a new dimension for the development of 3D objects.…”

Section: D Printingmentioning

confidence: 99%

Shape memory materials and 4D printing in pharmaceutics

Melocchi

Uboldi

Cerea

et al. 2021

Advanced Drug Delivery Reviews

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“…In addition, 4D printing technology can be used in drug delivery systems, scaffolds [213], and stents [214]. The 4D printed drug delivery systems can be stimulated by external parameters to release drugs, and 4D-printed containers [215,216] are popular examples, with the other example being expandable gastroretentive devices [217].…”

Section: Four-dimensional (4d) Printingmentioning

confidence: 99%

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Zhou

Attarilar

et al. 2021

Coatings

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Due to the growing aging population of the world, and as a result of the increasing need for dental implants and prostheses, the use of titanium and its alloys as implant materials has spread rapidly. Although titanium and its alloys are considered the best metallic materials for biomedical applications, the need for innovative technologies is necessary due to the sensitivity of medical applications and to eliminate any potentially harmful reactions, enhancing the implant-to-bone integration and preventing infection. In this regard, the implant’s surface as the substrate for any reaction is of crucial importance, and it is accurately addressed in this review paper. For constructing this review paper, an internet search was performed on the web of science with these keywords: surface modification techniques, titanium implant, biomedical applications, surface functionalization, etc. Numerous recent papers about titanium and its alloys were selected and reviewed, except for the section on forthcoming modern implants, in which extended research was performed. This review paper aimed to briefly introduce the necessary surface characteristics for biomedical applications and the numerous surface treatment techniques. Specific emphasis was given to micro/nano-structured topographies, biocompatibility, osteogenesis, and bactericidal effects. Additionally, gradient, multi-scale, and hierarchical surfaces with multifunctional properties were discussed. Finally, special attention was paid to modern implants and forthcoming surface modification strategies such as four-dimensional printing, metamaterials, and metasurfaces. This review paper, including traditional and novel surface modification strategies, will pave the way toward designing the next generation of more efficient implants.

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Can 4D bioprinting revolutionize drug development?

Cited by 25 publications

References 26 publications

3D bioprinting: current status and trends—a guide to the literature and industrial practice

3D bioprinting: current status and trends—a guide to the literature and industrial practice

Shape memory materials and 4D printing in pharmaceutics

Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

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