Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Li, Jie; Zhou, Peng; Attarilar, Shokouh; Shi, Hongyuan

doi:10.3390/coatings11060647

Cited by 26 publications

(22 citation statements)

References 217 publications

(256 reference statements)

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“…Surface modification of Ti based implants can be achieved by various physical, mechanical, or chemical treatments [11][12][13]. Some of these surface modification techniques include air-born abrasion [14], chemical treatment [15], and anodic oxidation [16].…”

Section: Of 16mentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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The current research aim is to biofunctionalize pure titanium (Ti, grade IV) substrate with titania nanotubes and Zn doped hydroxyapatite-based coatings by applying a duplex electrochemical treatment, and to evaluate the influence of Zn content on the physico-chemical properties of hydroxyapatite (HAp). The obtained nanostructured surfaces were covered with HAp-based coatings doped with Zn in different concentrations by electrochemical deposition in pulsed galvanostatic mode. The obtained surfaces were characterized in terms of morphology, elemental and phasic composition, chemical bonds, roughness, and adhesion. The nanostructured surface consisted of titania nanotubes (NT), aligned, vertically oriented, and hollow, with an inner diameter of ~70 nm. X-Ray Diffraction (XRD) analysis showed that the nanostructured surface consists of an anatase phase and some rutile peaks as a secondary phase. The morphology of all coatings consisted of ribbon like-crystals, and by increasing the Zn content the coating became denser due to the decrement of the crystals’ dimensions. The elemental and phase compositions evidenced that HAp was successfully doped with Zn through the pulsed galvanostatic method on the Ti nanostructured surfaces. Fourier Transform Infrared spectroscopy (FTIR) and XRD analysis confirmed the presence of HAp in all coatings, while the adhesion test showed that the addition of a high quantity leads to some delamination. Based on the obtained results, it can be said that the addition of Zn enhances the properties of HAp, and through proper experimental design, the concentration of Zn can be modulated to achieve coatings with tunable features.

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Section: Of 16mentioning

confidence: 99%

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

et al. 2022

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“…Tailoring the biomimetic titanium surface on Ti material has attracted much attention for it advantages in biocompatibility and osseointegration. 52 In natural condition, the structure of bone tissue varies at the micro- and macro-size scales. 53 Cortical bone reveals different scale of porous structures with the cancellous bone.…”

Section: Discussionmentioning

confidence: 99%

Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals

Yang¹,

Lin²,

Xu³

et al. 2022

IJN

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Background and Purpose In clinical application of dental implants, the functional state of dendritic cells (DCs) has been suggested to have a close relationship with the implant survival rate or speed of osseointegration. Although microscale surfaces have a stable osteogenesis property, they also incline to trigger unfavorable DCs activation and threaten the osseointegration process. Nanoscale structures have an advantage in regulating cell immune response through orchestrating cell adhesion, indicating the potential of hierarchical micro/nanostructured surface in regulation of DCs’ activation without sacrificing the advantage of microscale topography. Materials and Methods Two micro/nanostructures were fabricated based on microscale rough surfaces through anodization or alkali treatment, the sand-blasted and acid-etched (SA) surface served as control. The surface characteristics, in vitro and in vivo DC immune reactions and β2 integrin-FAK signal expression were systematically investigated. The DC responses to different surface topographies after FAK inhibition were also tested. Results Both micro/nano-modified surfaces exhibited unique composite structures, with higher hydrophilicity and lower roughness compared to the SA surface. The DCs showed relatively immature functional states with round morphologies and significantly downregulated β2 integrin-FAK levels on micro/nanostructures. Implant surfaces with micro/nano-topographies also triggered lower levels of DC inflammatory responses than SA surfaces in vivo. The inhibited FAK activation effectively reduced the differences in topography-caused DC activation and narrowed the differences in DC activation among the three groups. Conclusion Compared to the SA surface with solely micro-scale topography, titanium surfaces with hybrid micro/nano-topographies reduced DC inflammatory response by influencing their adhesion states. This regulatory effect was accompanied by the modulation of β2 integrin-FAK signal expression. The β2 integrin-FAK-mediated adhesion plays a critical role in topography-induced DC activation, which represents a potential target for material–cell interaction regulation.

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“…This process treats the surface of the implant with strong acids. After applying this procedure as a result, it produces uniform surface roughness, it also activates more amount of surface area [29][30][31][32].…”

Section: Acid Etchingmentioning

confidence: 99%

Detailed study on basic methodology of dental implant and surface modification techniques

Alagatu

Dhapade

Gajbhiye

et al. 2022

IOP Conf. Ser.: Mater. Sci. Eng.

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Dental implant can be defined as the process of inserting an artificial tooth in the place of natural tooth. This artificial tooth consists of: a) abutment b) Custom made crown and c) an implant. Since it is replacing the natural tooth, it should resemble and work in the same manner. It should not break under the chewing load. Dental implant shows great success rate but over the years. They are regarded as a significant contribution to dentistry since they have changed the process of replacing lost teeth. The capacity of the implant material to integrate with the surrounding tissue is critical to its success. Dental implants are artificial dental roots that are used to replace missing teeth. Dental implant is slightly expensive and patient has to go through plenty of processes like surgery. Moreover, even after taking all the preventive measures there are still chances of failing the implant and hence material selection and surface modification techniques used in Dental implant plays a crucial role. In this review paper we will see the different material used in dental implant and different surface modification techniques.

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Innovative Surface Modification Procedures to Achieve Micro/Nano-Graded Ti-Based Biomedical Alloys and Implants

Cited by 26 publications

References 217 publications

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Electrochemical Surface Biofunctionalization of Titanium through Growth of TiO2 Nanotubes and Deposition of Zn Doped Hydroxyapatite

Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals

Detailed study on basic methodology of dental implant and surface modification techniques

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