Callophycin A loaded chitosan and spicules based nanocomposites as an alternative strategy to overcome vaginal candidiasis

Arumugam, G; Rajendran, R.

doi:10.1016/j.ijbiomac.2020.06.119

Cited by 9 publications

(6 citation statements)

References 48 publications

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“…Callophycin A-loaded CNPs showed significant anticandidal activity both in vitro and in the vulvovaginal candidiasis animal model after six days of treatment. The CNPs alone did not exhibit antifungal activity; however, a synergetic effect between Callophycin A and CNPs was determined [286].…”

Section: Particles and Carriersmentioning

confidence: 94%

“…Clotrimazole Decreased antifungal activity in vitro but improved safety profile for CNP-associated clotrimazole [285] Callophycin A Synergetic and improved antifungal effect both in vitro and in vivo by Callophycin A in CNPs [286] Thiosemicarbazide CNP-associated thiosemicarbazide obtained a prominent reduction of fungal burden in vivo [287] Miconazole CNPs containing a seven-fold lower miconazole concentration than conventional miconazole cream obtained equal therapeutic effect [288] Miconazole and farnesol…”

Section: Candidiasismentioning

confidence: 99%

“…Many natural substances show promise as alternatives to antibiotics in treating infections. Arumugam and Rajendran incorporated Callophycin A, a seaweed-derived metabolite, into CNPs and studied in vitro and in vivo anticandidal effects [286]. Callophycin A-loaded CNPs showed significant anticandidal activity both in vitro and in the vulvovaginal candidiasis animal model after six days of treatment.…”

Section: Particles and Carriersmentioning

confidence: 99%

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The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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Chitosan is one of the most studied natural origin polymers for biomedical applications. This review focuses on the potential of chitosan in localized antimicrobial therapy to address the challenges of current rising antimicrobial resistance. Due to its mucoadhesiveness, chitosan offers the opportunity to prolong the formulation residence time at mucosal sites; its wound healing properties open possibilities to utilize chitosan as wound dressings with multitargeted activities and more. We provide an unbiased overview of the state-of-the-art chitosan-based delivery systems categorized by the administration site, addressing the site-related challenges and evaluating the representative formulations. Specifically, we offer an in-depth analysis of the current challenges of the chitosan-based novel delivery systems for skin and vaginal infections, including its formulations optimizations and limitations. A brief overview of chitosan’s potential in treating ocular, buccal and dental, and nasal infections is included. We close the review with remarks on toxicity issues and remaining challenges and perspectives.

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Section: Particles and Carriersmentioning

confidence: 94%

Section: Candidiasismentioning

confidence: 99%

Section: Particles and Carriersmentioning

confidence: 99%

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The Expanded Role of Chitosan in Localized Antimicrobial Therapy

2021

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“…Also, chitosan nanoparticles have been used in various diseases, for example, anxiety disorders [115]; and Neuroprotection in Alzheimer's disease [116]. Further, the mucoadhesive property of chitosan may also be useful for the administration of drugs for controlled oral, nasal, ocular [84], vaginal [117] local, and transdermal administration [81].…”

Section: Applications Of Chitosan Nanoparticles and Nanocapsulesmentioning

confidence: 99%

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Shoueir

El-Desouky

Rashad

et al. 2021

International Journal of Biological Macromolecules

118

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“…The treatment using the CS NPs with miconazole nitrate provided the same therapeutic efficacy as miconazole nitrate in a commercial cream formulation but using the antifungal content about seven-fold lower. In another work, Arumugam et al [211] studied the killing effects of seaweed-derived metabolite Callophycin A (Cal) loaded in both chitosan (Cal-CS) and marine spongederived spicules (Cal-Spi) NPs. Vaginal candidiasis-induced animal model experiments confirmed that the candidicidal activity of Cal-CS NPs resulted in a significant reduction in the fungal burden of vaginal lavage.…”

Section: Vaginal Drug Deliverymentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

248

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Callophycin A loaded chitosan and spicules based nanocomposites as an alternative strategy to overcome vaginal candidiasis

Cited by 9 publications

References 48 publications

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

The Expanded Role of Chitosan in Localized Antimicrobial Therapy

Chitosan based-nanoparticles and nanocapsules: Overview, physicochemical features, applications of a nanofibrous scaffold, and bioprinting

Advances in Chitosan-Based Nanoparticles for Drug Delivery

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