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Rett syndrome is a complex neurodevelopmental disorder that is mainly caused by mutations in MECP2 . However, mutations in FOXG1 cause a less frequent form of atypical Rett syndrome, called FOXG1 syndrome. FOXG1 is a key transcription factor crucial for forebrain development, where it maintains the balance between progenitor proliferation and neuronal differentiation. Using genome-wide small RNA sequencing and quantitative proteomics, we identified that FOXG1 affects the biogenesis of miR200b/a/429 and interacts with the ATP-dependent RNA helicase, DDX5/p68. Both FOXG1 and DDX5 associate with the microprocessor complex, whereby DDX5 recruits FOXG1 to DROSHA. RNA-Seq analyses of Foxg1 cre/+ hippocampi and N2a cells overexpressing miR200 family members identified cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B) as a target of miR200 in neural cells. PRKAR2B inhibits postsynaptic functions by attenuating protein kinase A (PKA) activity; thus, increased PRKAR2B levels may contribute to neuronal dysfunctions in FOXG1 syndrome. Our data suggest that FOXG1 regulates PRKAR2B expression both on transcriptional and posttranscriptional levels. Electronic supplementary material The online version of this article (10.1007/s12035-018-1444-7) contains supplementary material, which is available to authorized users.

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In this work, a simple, nontoxic, and eco-friendly method for recycling organic-based expired medicines into activated carbon was proposed. The formation, structural, and morphological features of the sample were proved by different physico-chemical tools such as Fourier transform infrared, Raman, X-ray diffraction, Brunauer-Emmett-Teller, thermogravimetric analysis, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, and transmission electron microscopy analysis. Further, expired medicine-derived activated carbon (Em AC) was used as electrode material for supercapacitor devices, and its biocompatibility was studied. The cyclic voltammetry and galvanostatic charge-discharge measurement electrochemical impedance spectroscopic analysis were used to investigate the electrochemical properties of the fabricated Em AC@Ni foil electrode. The as-fabricated electrode delivered specific capacitance (C sp ) value of 480 F/g at the current density of 1 A/g. Also, the electrode exhibited superior cyclic stability and maintained 88% of its capacitance value upto the completion of 8000 GCD cycles at the current density of 2 A/g. Further, Em AC-based symmetric device achieved the energy density of 28.33 Wh kg À1 at the power density of 666.01 W kg À1 . Hence, the porous Em AC sample was identified as the promising electrode material for future energy storage devices without distracting any damage to the biological system.

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In this work, we recovered aluminium oxide nanoparticles (Al 2 O 3 NP's) from aluminium based wastes by adopting sonochemical assisted leaching technique. The structural/chemical composition of the as-recovered Al 2 O 3 NP's was explored by various spectral and analytical tools, such as FT-IR, Raman, XRD, XPS, FE-SEM, TEM and BET analysis. The as-recovered Al 2 O 3 NP's were employed as electrode material in supercapacitor, which further revealed an appreciable specific capacitance value (688 Fg −1 ) in 1 M KOH at 1 Ag −1 current density. Further, Al 2 O 3 NP's conserved 86 % capacitance retention even after 3000 GCD cycles. Furthermore, the biocidal activity of the as-recovered Al 2 O 3 was tested and it was found to be lesser toxic to the bacterial and yeast cells. Thus, the study revealed that Al 2 O 3 NP's can be used to develop the ecofriendly superior electrode material for supercapacitor application.