Calcium Phosphate Cement

Ishikawa, Kunio

doi:10.1007/978-3-642-53980-0_7

Cited by 20 publications

(7 citation statements)

References 78 publications

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“…Therefore, the new idea was to use a coating with a faster precipitation rate, which could provide a more uniform coating. Since brushite cement has a short setting time and also reduces the pH of the medium [41,42], it can be used as a coating on calcium silicate samples. According to the solubility phase diagram of calcium phosphates as a function of pH, the most stable phase would be DCPD at a pH lower than 4.2 and a calcium concentration of more than 32 mM [41].…”

Section: Characterization Of Coatingmentioning

confidence: 99%

“…Since brushite cement has a short setting time and also reduces the pH of the medium [41,42], it can be used as a coating on calcium silicate samples. According to the solubility phase diagram of calcium phosphates as a function of pH, the most stable phase would be DCPD at a pH lower than 4.2 and a calcium concentration of more than 32 mM [41]. Therefore, 1% MCP solution with a pH of about 3.8 provides an acidic medium, and also acts as a source of phosphate ions for the acid-base reaction and DCPD precipitation via the following reactions:…”

Section: Characterization Of Coatingmentioning

confidence: 99%

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Novel calcium phosphate coated calcium silicate-based cement: in vitro evaluation

et al. 2020

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Calcium silicate-based cements are known for their wide applications in dentistry and orthopedics. The alkaline pH (up to 12) of these cements limits their application in other orthopedic areas. In this study, the effect of dicalcium phosphate dihydrate (DCPD) coating on set cement on pH reduction and biocompatibility improvement was examined. Samples with 0 and 10 weight ratio DCPD were prepared and characterized by XRD, FTIR, and SEM. The DCPD coating on the set cement was performed by a 7 d immersion in 1% monocalcium phosphate (MCP) solution and characterized by XRD, FTIR, SEM, and EDX. Also, the compressive strength and cytotoxicity of the samples were tested. The results showed that DCPD coating did not significantly change the compressive strength of the cement, but by decreasing the pH of the culture medium to the physiological range, it led to enhance adhesion, spreading and proliferation of human osteosarcoma cell line (Saos-2). The novel DCPD coated calcium silicate-based cement could be served as a bulk or porous bone substitute and scaffold.

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Section: Characterization Of Coatingmentioning

confidence: 99%

Section: Characterization Of Coatingmentioning

confidence: 99%

Novel calcium phosphate coated calcium silicate-based cement: in vitro evaluation

et al. 2020

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“…These demonstrate properties extending from bioresorbable to bioactive class A. Clinically, β-TCP (bioresorbable) and synthetic hydroxyapatite (HA) (bioactive) are the more widely used traditionally [1,7,8], but their slow dissolution rate is a limiting factor [9,10]. Indeed, concerns have been addressed pertaining to the limited resorption of those ceramics, in-vivo, when used in cements [11]. BAG is a sub-category of ceramics showing not only osteoconduction, as in synthetic HA, but also osteoinduction [12].…”

Section: Introductionmentioning

confidence: 99%

Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass

Houaoui

Lyyra

Agniel

et al. 2020

Materials Science and Engineering: C

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“…Clearly, this requirement arose from the self-setting mechanism of calcium phosphate cements, including apatite- and DCPD-forming cements. 1,13–22 In the case of apatite-forming cements, the dissolution–precipitation reaction requires a neutral pH, as apatite is stable at neutral pH. For example, the apatite cement proposed by Monma and Kanazawa 22 employed a α-TCP powder, which dissolves in water, releasing Ca 2+ and PO42− into solution (equation (2)).…”

Section: Discussionmentioning

confidence: 99%

Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution

et al. 2018

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Bridging beta-tricalcium phosphate (b-TCP) granules with dicalcium phosphate dihydrate (DCPD) creates a porous, interconnected b-TCP granular cement (GC) that is useful for reconstructing bone defects: the interconnected pores can accelerate new bone ingrowth and the set cement prevents the loss of granules from the bone defect area. However, the setting time of b-TCP GC in an acidic calcium phosphate solution is too short (<1 min) for handling in clinical applications, such as in orthopedic surgery. To address this issue, we sought to optimize the setting time of b-TCP GC using b-TCP granules and NaHSO 4 solution, as SO 2À 4 is a known inhibitor of DCPD formation. Both DCPD and calcium sulfate dihydrate (CSD) precipitated on the surface of b-TCP granules and bridged b-TCP granules to one another. Increasing NaHSO 4 concentration (from 0.5 mol/L to 5 mol/L) led to an increase in the amount of precipitant from 2.6 AE 0.2% to 21.6 AE 1.3% for DCPD and 1.3 AE 0.3% to 10.1 AE 0.5% for CSD. The diametral tensile strength was also increased from 0.03 AE 0.01 MPa to 2.0 AE 0.1 MPa with increasing NaHSO 4 concentration. When 2 mol/L NaHSO 4 solution was used as the liquid phase, setting time became 5.3 AE 0.2 min, which is suitable for handling in clinical applications to repair bone defects. In conclusion, b-TCP GC using NaHSO 4 solution as the liquid phase has good potential value as bone augmentation cement.

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Calcium Phosphate Cement

Cited by 20 publications

References 78 publications

Novel calcium phosphate coated calcium silicate-based cement: in vitro evaluation

Novel calcium phosphate coated calcium silicate-based cement: in vitro evaluation

Dissolution, bioactivity and osteogenic properties of composites based on polymer and silicate or borosilicate bioactive glass

Fabrication of self-setting β-TCP granular cement using β-TCP granules and sodium hydrogen sulfate solution

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