Calcium ion mediated rapid wound healing by nano-ZnO doped calcium phosphate-chitosan-alginate biocomposites

Rahman, Md. Ashiqur; Islam, Md. Sazedul; Haque, Papia; Khan, M. Nuruzzaman; Takafuji, Makoto; Begum, Mst. Marium; Chowdhury, Gawsia Wahidunnessa; Rahman, Mohammed Mizanur

doi:10.1016/j.mtla.2020.100839

Cited by 38 publications

(15 citation statements)

References 37 publications

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“…This awakens the need of search for alternative materials for bone transplantation and reconstruction purposes, standing out the development of 3D scaffolds systems for bone tissue engineering, which are biocompatible, biodegradable, and favor cell adhesion and proliferation. In this sense, scaffolds made of ceramic nanofibers displays interesting characteristics, such as nanorugosity, nanotopography, wettability, bioactivity, and ECM-like morphology, which favor cell multiplication and have shown promising results for the repair and rebuild of damaged bones, including critical defects [ 99 , 100 ].…”

Section: Bone Regenerationmentioning

confidence: 99%

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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Ceramic nanofibers have been shown to be a new horizon of research in the biomedical area, due to their differentiated morphology, nanoroughness, nanotopography, wettability, bioactivity, and chemical functionalization properties. Therefore, considering the impact caused by the use of these nanofibers, and the fact that there are still limited data available in the literature addressing the ceramic nanofiber application in regenerative medicine, this review article aims to gather the state-of-the-art research concerning these materials, for potential use as a biomaterial for wound healing and bone regeneration, and to analyze their characteristics when considering their application.

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Section: Bone Regenerationmentioning

confidence: 99%

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

et al. 2022

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“…These results differ from those reported in previous studies with Alg−Chi polymers in the Vero cell line, as we observed 10% cytotoxicity (cell viability of 90%) [ 42 ]. Alginate and chitosan have been used in studies aimed at drug delivery and as healing polymers for skin wounds owing to their biocompatible properties, with low cytotoxicity in Vero cell lines and BHK-21 cells [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Immobilization Systems of Antimicrobial Peptide Ib−M1 in Polymeric Nanoparticles Based on Alginate and Chitosan

et al. 2022

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The development of new strategies to reduce the use of traditional antibiotics has been a topic of global interest due to the resistance generated by multiresistant microorganisms, including Escherichia coli, as etiological agents of various diseases. Antimicrobial peptides are presented as an alternative for the treatment of infectious diseases caused by this type of microorganism. The Ib−M1 peptide meets the requirements to be used as an antimicrobial compound. However, it is necessary to use strategies that generate protection and resist the conditions encountered in a biological system. Therefore, in this study, we synthesized alginate and chitosan nanoparticles (Alg−Chi NPs) using the ionic gelation technique, which allows for the crosslinking of polymeric chains arranged in nanostructures by intermolecular interactions that can be either covalent or non-covalent. Such interactions can be achieved through the use of crosslinking agents that facilitate this binding. This technique allows for immobilization of the Ib−M1 peptide to form an Ib−M1/Alg−Chi bioconjugate. SEM, DLS, and FT-IR were used to determine the structural features of the nanoparticles. We evaluated the biological activity against E. coli ATCC 25922 and Vero mammalian cells, as well as the stability at various temperatures, pH, and proteases, of Ib−M1 and Ib−M1/Alg-Chi. The results showed agglomerates of nanoparticles with average sizes of 150 nm; an MIC of 12.5 µM, which was maintained in the bioconjugate; and cytotoxicity values close to 40%. Stability was maintained against pH and temperature; in proteases, it was only evidenced against pepsin in Ib−M1/Alg-Chi. The results are promising with respect to the use of Ib−M1 and Ib−M1/Alg−Chi as possible antimicrobial agents.

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“…In the stretching vibrations of -COOasymmetric and -COOsymmetrically, there was a shift from 1620 to 1627 cm −1 and 1419 to 1427 cm −1 [21]. This vibrational shift indicates an ionic interaction between the carboxylate group -COOof alginate and chitosan's amino group (-NH 3 + ) [22]. In addition, a new weak absorption peak at 1527 cm −1 was identified as a Ca 2+ ion as a crosslinker and electrostatically bound to the carboxyl group [23].…”

Section: Characterization Of Cac Using Ftirmentioning

confidence: 94%

Carbon/Alginate/Chitosan Composite as a Sorbent for Solid-Phase Extraction and Preconcentration of Cu(II)

et al. 2022

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Carbon/Alginate/Chitosan Composite (CAC) as a sorbent for solid-phase extraction of Cu(II) (pre-concentration) with atomic absorption spectrometry for analysis was successfully prepared. The sorbent was made with a mass ratio of chitosan:alginate:carbon = 1:1:1. CAC sorbents were characterized using FTIR for functional group analysis while SEM-EDX characterization was performed to determine surface morphology and percentage of elements. SPE parameters were optimized for adsorption-desorption efficiency under various conditions, i.e. of pH 5, Cu(II) concentration of 4 mg/L, the flow rate of Cu(II), and Na2EDTA eluent at 5 mL/min, the volume of Cu(II) sample and Na2EDTA eluent 25 mL and 1.0 M of Na2EDTA eluent concentration. Applying CAC-based SPE for Cu(II) analysis in water samples at optimum conditions gave 80.9–83.6% recovery. In bottled drinking water samples, a pre-concentration factor of 2.5–5 times was obtained, and the Cu(II) concentration of 0.017–0.020 mg/L was detected.

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Calcium ion mediated rapid wound healing by nano-ZnO doped calcium phosphate-chitosan-alginate biocomposites

Cited by 38 publications

References 37 publications

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Ceramic Nanofiber Materials for Wound Healing and Bone Regeneration: A Brief Review

Immobilization Systems of Antimicrobial Peptide Ib−M1 in Polymeric Nanoparticles Based on Alginate and Chitosan

Carbon/Alginate/Chitosan Composite as a Sorbent for Solid-Phase Extraction and Preconcentration of Cu(II)

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