Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

Küçükkaya, Bahire; Başoğlu, Harun; Erdag, Demet; Akbaş, Fahri; Süsgün, Seda; Yalcintepe, Leman

doi:10.4149/gpb_2019013

Cited by 15 publications

(10 citation statements)

References 60 publications

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“…Similarly, OSW-1, a natural saponin, and potential anticancer treatment blocks NCX activity in acute leukemia cell line (HL-60) and induces cytotoxicity via accumulation of excess Ca 2+ ion in the cytosol [ 252 ]. In cancer cells exposed to hypoxia, the reverse mode NCX functioning is coupled to carbonic anhydrase IX (CA1X) and sodium-hydrogen exchanger (NHE1) for converting the intracellular proton load (occurring due to metabolic changes during hypoxia) into interstitial acidosis [ 253 , 254 ]. This allows the breakdown of the extracellular matrix and consequently, promotes tumor cell migration and invasion [ 253 , 255 ].…”

Section: Redistribution Of Intracellular Ca 2+ and Hijack Of Its Regulatory Machinery In Cancer Cellsmentioning

confidence: 99%

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

2021

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Intracellular Ca2+ distribution is a tightly regulated process. Numerous Ca2+ chelating, storage, and transport mechanisms are required to maintain normal cellular physiology. Ca2+-binding proteins, mainly calmodulin and calbindins, sequester free intracellular Ca2+ ions and apportion or transport them to signaling hubs needing the cations. Ca2+ channels, ATP-driven pumps, and exchangers assist the binding proteins in transferring the ions to and from appropriate cellular compartments. Some, such as the endoplasmic reticulum, mitochondria, and lysosomes, act as Ca2+ repositories. Cellular Ca2+ homeostasis is inefficient without the active contribution of these organelles. Moreover, certain key cellular processes also rely on inter-organellar Ca2+ signaling. This review attempts to encapsulate the structure, function, and regulation of major intracellular Ca2+ buffers, sensors, channels, and signaling molecules before highlighting how cancer cells manipulate them to survive and thrive. The spotlight is then shifted to the slow pace of translating such research findings into anticancer therapeutics. We use the PubMed database to highlight current clinical studies that target intracellular Ca2+ signaling. Drug repurposing and improving the delivery of small molecule therapeutics are further discussed as promising strategies for speeding therapeutic development in this area.

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Section: Redistribution Of Intracellular Ca 2+ and Hijack Of Its Regulatory Machinery In Cancer Cellsmentioning

confidence: 99%

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

2021

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“…Interestingly, the aberrant expression of SERCAs is also associated with chemoresistance. In this aspect, several studies reported that SERCA1–3 are markedly decreased in cisplatin-resistant MDAH-2774 ovarian cancer cell lines [ 67 ], and in low-level cisplatin-resistant non-small-cell lung cancer cells H1339 [ 68 ]. A link between altered SERCA and cancer has led to the development of several modulators to either activate/restore or inhibit SERCA for the treatment of different cancers with dysregulated or impaired SERCA.…”

Section: Membrane Pumpsmentioning

confidence: 99%

Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

Almasi

Hiani

2020

Cancers

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Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogenesis and chemoresistance has opened new vistas for pharmacology-based cancer research. This review provides a comprehensive update of our current knowledge on the functional expression profile of membrane transport proteins in cancer and chemoresistant tumours that may form the basis for new cancer treatment strategies.

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“…Mounting evidence indicates that many SERCAs are down-regulated in cancer. For instance, the SERCA1 isoform is decreased in cisplatin-resistant epithelial ovarian cancer cell line MDAH-2774 [ 160 ]. SERCA2b expression is significantly reduced in small cell lung cancer, thyroid cancer, oral squamous cell carcinoma and colon cancer [ 161 , 162 , 163 , 164 ].…”

Section: Er Ca 2+ Transporters and Cancer Pathomentioning

confidence: 99%

Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection

Zhai

Sterea

Hiani

2020

Cells

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Ca2+ is an integral mediator of intracellular signaling, impacting almost every aspect of cellular life. The Ca2+-conducting transporters located on the endoplasmic reticulum (ER) membrane shoulder the responsibility of constructing the global Ca2+ signaling landscape. These transporters gate the ER Ca2+ release and uptake, sculpt signaling duration and intensity, and compose the Ca2+ signaling rhythm to accommodate a plethora of biological activities. In this review, we explore the mechanisms of activation and functional regulation of ER Ca2+ transporters in the establishment of Ca2+ homeostasis. We also contextualize the aberrant alterations of these transporters in carcinogenesis, presenting Ca2+-based therapeutic interventions as a means to tackle malignancies.

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Calcium homeostasis in cisplatin resistant epithelial ovarian cancer

Cited by 15 publications

References 60 publications

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

Advances in Intracellular Calcium Signaling Reveal Untapped Targets for Cancer Therapy

Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

Lessons from the Endoplasmic Reticulum Ca2+ Transporters—A Cancer Connection

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