2020
DOI: 10.3390/cancers12061624
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Exploring the Therapeutic Potential of Membrane Transport Proteins: Focus on Cancer and Chemoresistance

Abstract: Improving the therapeutic efficacy of conventional anticancer drugs represents the best hope for cancer treatment. However, the shortage of druggable targets and the increasing development of anticancer drug resistance remain significant problems. Recently, membrane transport proteins have emerged as novel therapeutic targets for cancer treatment. These proteins are essential for a plethora of cell functions ranging from cell homeostasis to clinical drug toxicity. Furthermore, their association with carcinogen… Show more

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Cited by 17 publications
(19 citation statements)
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References 292 publications
(309 reference statements)
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“…In view of the critical role of cell plasma membrane transport proteins, modulation of their basal performance is associated with multiple pathologies [ 2 , 4 , 6 , 7 ]. Targeting these transport proteins, which include channels and pores, ATP-powered pumps and porters ( Figure 1 E), would be of therapeutic interest [ 2 , 5 , 8 , 9 ].…”
Section: Structure and Function Of Cell Plasma Membrane Transport mentioning
confidence: 99%
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“…In view of the critical role of cell plasma membrane transport proteins, modulation of their basal performance is associated with multiple pathologies [ 2 , 4 , 6 , 7 ]. Targeting these transport proteins, which include channels and pores, ATP-powered pumps and porters ( Figure 1 E), would be of therapeutic interest [ 2 , 5 , 8 , 9 ].…”
Section: Structure and Function Of Cell Plasma Membrane Transport mentioning
confidence: 99%
“…Therapeutic nanobodies targeting cell plasma membrane transport proteins are being developed to interfere with the function of these channels and pores, ATP-powered pumps and porters [ 2 , 5 , 8 , 9 ]. Such therapeutic nanobodies may exert these functional effects via different mechanisms.…”
Section: Antibodies and Nanobodies To Target Cell Plasma Membrane mentioning
confidence: 99%
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“…The available information allows hypothesizing that electroporation may be an effective method against ovarian cancer. Additionally, the controlled concentration of 17β-estradiol may have a protective or toxic effect on the MDAH-2774 ovarian cancer cell line, which expresses estrogen receptors (ERs) [ 40 , 41 ]. The presented research aimed to evaluate the modulating effect of 17β-estradiol on the effectiveness of chemotherapy and electrochemotherapy with the use of cisplatin and calcium chloride in human ovarian cancer.…”
Section: Introductionmentioning
confidence: 99%