Electrochemotherapy with Calcium Chloride and 17β-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer

Łapińska, Zofia; Dębiński, Michał; Szewczyk, Anna; Choromańska, Anna; Kulbacka, Julita; Saczko, Jolanta

doi:10.3390/pharmaceutics13010019

Cited by 12 publications

(7 citation statements)

References 54 publications

(69 reference statements)

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“…36 In general, the use of CaEP revealed similar effects. 35,37 Electrochemotherapy has a promising potential and can be used for inoperable, chemoresistant and radioresistant tumors that do not respond to the current standard of treatment. 38 Preliminary clinical studies on BC metastasis to the skin and subcutaneous tissue demonstrated the high effectiveness of ECT as a palliative treatment, with a significant improvement in the patient's quality of life.…”

Section: Studies On Ep and Ect In Breast Cancermentioning

confidence: 99%

Novel electroporation-based treatments for breast cancer

Łapińska¹,

Saczko²

2022

Adv Clin Exp Med

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Breast cancer (BC) is the most common cancer in women, and its incidence is increasing every year. Current treatment is based on surgical resection, chemotherapy (CT), radiotherapy, and hormone therapy (HT). Unfortunately, these methods are ineffective and are associated with a wide range of side effects (e.g., nausea, hair loss and fertility disorders). Electrochemotherapy (ECT), which exposes tumor cells to electric pulses (known as electroporation (EP)) in combination with cytostatic drugs, enables the reduction of cytotoxic drug doses while increasing their efficacy. Electroporation-based treatment methods are applied in breast carcinoma and are the subject of intensive research globally. Irreversible EP has shown promising therapeutic potential in the absence of cytotoxic drugs, as has EP associated with molecules such as calcium ions that are already present in the human body. The application of EP-based methods seems to be a safer and more effective treatment for BC in vitro and in vivo. Indeed, they have found applications in the treatment of BC and its metastases. Moreover, their palliative effects have also been established, and pain reduction has been noted in patients.

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Section: Studies On Ep and Ect In Breast Cancermentioning

confidence: 99%

Novel electroporation-based treatments for breast cancer

Łapińska¹,

Saczko²

2022

Adv Clin Exp Med

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“…Recently, Łapinska et al further analyzed the role of CSP-based ECT in ovarian cancer in combination with estradiol [ 56 ]. Indeed, it is well known that the biological mechanisms of ovarian cancer development and progression are tightly linked to estrogen hormones.…”

Section: Systematic Review Of Studies On Electroporation Combined With Cisplatinmentioning

confidence: 99%

Electrochemotherapy in Vulvar Cancer and Cisplatin Combined with Electroporation. Systematic Review and In Vitro Studies

Perrone

Ravegnini

Miglietta

et al. 2021

Cancers

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Electrochemotherapy (ECT) is an emerging treatment for solid tumors and an attractive research field due to its clinical results. This therapy represents an alternative local treatment to the standard ones and is based on the tumor-directed delivery of non-ablative electrical pulses to maximize the action of specific cytotoxic drugs such as cisplatin (CSP) and bleomycin (BLM) and to promote cancer cell death. Nowadays, ECT is mainly recommended as palliative treatment. However, it can be applied to a wide range of superficial cancers, having an impact in preventing or delaying tumor progression and therefore in improving quality of life. In addition, during the natural history of the tumor, early ECT may improve patient outcomes. Our group has extensive clinical and research experience on ECT in vulvar tumors in the palliative setting, with 70% overall response rate. So far, in most studies, ECT was based on BLM. However, the potential of CSP in this setting seems interesting due to some theoretical advantages. The purpose of this report is to: (i) compare the efficacy of CSP and BLM-based ECT through a systematic literature review; (ii) report the results of our studies on CSP-resistant squamous cell tumors cell lines and the possibility to overcome chemoresistance using ECT; (iii) discuss the future ECT role in gynecological tumors and in particular in vulvar carcinoma.

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“…Other in vitro studies showed that ECT could be an effective treatment in combination with bleomycin. A potentiating effect was observed in human ovarian cancer cells (MDAH-2774) expressing ER, in combination with hormonal (17β-estradiol-based) therapies [ 95 ]. ECT could also be used in patients with deep gynecological tumors.…”

Section: Treatment Of Solid Tumors With Ectmentioning

confidence: 99%

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

Condello

D'Avack

Spugnini³

et al. 2022

Cancers

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Electrochemotherapy (ECT) is one of the innovative strategies to overcome the multi drug resistance (MDR) that often occurs in cancer. Resistance to anticancer drugs results from a variety of factors, such as genetic or epigenetic changes, an up-regulated outflow of drugs, and various cellular and molecular mechanisms. This technology combines the administration of chemotherapy with the application of electrical pulses, with waveforms capable of increasing drug uptake in a non-toxic and well tolerated mechanical system. ECT is used as a first-line adjuvant therapy in veterinary oncology, where it improves the efficacy of many chemotherapeutic agents by increasing their uptake into cancer cells. The chemotherapeutic agents that have been enhanced by this technique are bleomycin, cisplatin, mitomycin C, and 5-fluorouracil. After their use, a better localized control of the neoplasm has been observed. In humans, the use of ECT was initially limited to local palliative therapy for cutaneous metastases of melanoma, but phase I/II studies are currently ongoing for several histotypes of cancer, with promising results. In this review, we described the preclinical and clinical use of ECT on drug-resistant solid tumors, such as head and neck squamous cell carcinoma, breast cancer, gynecological cancer and, finally, colorectal cancer.

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Electrochemotherapy with Calcium Chloride and 17β-Estradiol Modulated Viability and Apoptosis Pathway in Human Ovarian Cancer

Cited by 12 publications

References 54 publications

Novel electroporation-based treatments for breast cancer

Novel electroporation-based treatments for breast cancer

Electrochemotherapy in Vulvar Cancer and Cisplatin Combined with Electroporation. Systematic Review and In Vitro Studies

Electrochemotherapy: An Alternative Strategy for Improving Therapy in Drug-Resistant SOLID Tumors

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