Calciphylaxis with pseudoxanthoma elasticum‐like changes: A case series

Abstract

The presence of PXE-like changes in the subcutis may heighten suspicion for a diagnosis of calciphylaxis in the appropriate clinical setting and be helpful when classic histologic features are subtle or absent.

Calciphylaxis and nephrogenic fibrosing dermopathy with pseudoxanthoma elasticum‐like changes: Successful treatment with sodium thiosulfate

“…Calciphylaxis and NFD usually develops in the setting of chronic renal failure with hemodialysis. [1][2][3][4] NFD is clinically manifested with symmetrical skin sclerosis in limbs and trunk and joint contructure. 2,4 Histologically, increased collagen fibers is characteristic.…”

“…[1][2][3][4] NFD is clinically manifested with symmetrical skin sclerosis in limbs and trunk and joint contructure. 2,4 Histologically, increased collagen fibers is characteristic. Histopathological changes, including dystrophic dermal calcification, often in association with elastic fibers have been observed in NFD or calciphylaxis.…”

“…Histopathological changes, including dystrophic dermal calcification, often in association with elastic fibers have been observed in NFD or calciphylaxis. [2][3][4] Particularly, a pattern of dermal elastic fiber calcification that mimics PXE is sometimes observed in calciphylaxis. Penn et al 4 reported that six of the 13 calciphylaxis tissue specimens demonstrated PXE-like histological features.…”

“…[2][3][4] Particularly, a pattern of dermal elastic fiber calcification that mimics PXE is sometimes observed in calciphylaxis. Penn et al 4 reported that six of the 13 calciphylaxis tissue specimens demonstrated PXE-like histological features. However, to our knowledge, there is only one report of the concomitant presence of calciphylaxis and NFD with PXE-like histological changes.…”

“…3 Interleukin (IL)-1 are major inflammatory cytokines, and patients with psoriasis persistently exposed to higher levels of IL-1 have a risk of arteriosclerosis. 4 Recently, it was reported that moderate to severe psoriasis is associated with moderate to advanced CKD, independent of traditional risk factors. 5 We routinely perform blood examination during apremilast treatment because we have experienced apremilast-induced liver injury.…”