Calciphylaxis: Risk Factors and Histologic Findings in a Case Series From a Tertiary Care Referral Hospital

Sánchez-Pujol, María José; Simón, A. Docampo; Gambín, F. Illán; Jaime, María Nivéiro de; Martínez, M.

doi:10.1016/j.adengl.2021.07.003

Cited by 3 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can progress to necrotic eschars, non-healing ulcers, and eventually gangrene [ 9 ]. On histology, it is characterized by calcium deposition on the medial layer of vessel walls and hyperplasia or fibrosis of the intima, in addition to thrombosis of small vessels [ 10 ]. The risk factors for calciphylaxis that our patient possessed included female sex, diabetes mellitus, hypoalbuminemia, warfarin usage, hyperphosphatemia, obesity, and length of dialysis [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The gold standard of diagnosis for calciphylaxis is a skin biopsy; however, due to its associated risk, it is controversial among the medical community as it may cause necrosis, infection, or facilitate the development of new lesions [ 4 , 5 , 10 ]. The diagnosis can also be supported by clinical findings of necrotic skin lesions with risk factors significant for calciphylaxis [ 10 ]. Our patient was on warfarin, and its use is associated with an increased risk for calciphylaxis [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease

Khudair,

Awadh

et al. 2023

Cureus

View full text Add to dashboard Cite

Calciphylaxis, or calcific uremic arteriolopathy, is a rare and deadly disease that affects patients with end-stage renal disease (ESRD). It typically manifests in the abdomen and lower extremities. We present a case of a 59-year-old female patient on dialysis due to ESRD who complained of a three-week history of hemorrhagic and painful bilateral lower limb lesions. The predominant clinical suspicion was warfarin-induced skin necrosis (WISN); however, the persistence of unresolved skin lesions post-warfarin cessation generated the impression of calciphylaxis. A skin biopsy confirmed the classical histological findings associated with calciphylaxis. This paper highlights the possible importance of warfarin being an inciting event, as well as the early differentiation between the presentations of WISN and calciphylaxis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease

Khudair,

Awadh

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…The etiology and pathogenesis of calciphylaxis are complex and have yet to be clarified. The interaction between various promoters and inhibitors of calcification has been implicated 3 , 4 . The incidence of calciphylaxis in dialysis patients ranges from 0.04 to 4%, and the rate appears to be rising over the last decade 1 , 2 , 5 .…”

Section: Introductionmentioning

confidence: 99%

“…The suspicion of calciphylaxis is based on clinical findings (ulcerative-necrotic cutaneous lesions) in a patient with risk factors 1 , 3 , 4 . CUA management lacks strong evidence 1 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Calciphylaxis during the course of psoriatic arthritis patient. Is it coincidence? A case report

Khalayli,

Hodifa,

Hodaifa

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and importance: Calciphylaxis manifests clinically by skin ischemia and necrosis and histologically by calcification of dermal arterioles. Usually, it occurs in patients with end-stage renal disease on dialysis or in patients who had a kidney transplant. Here, the authors present a case of calciphylaxis occurring in a patient with psoriasis and psoriatic arthritis. Case presentation: A 66-year-old Syrian male with a history of psoriatic arthritis presented for evaluation of 2-month nonpainful ulcers on his feet and hands that were treated with warfarin. Biopsies confirmed the diagnosis of calciphylaxis. The patient received sodium thiosulfate, zoledronic acid, intralesional sodium thiosulfate injections, and an intravenous infusion of vitamin K with dramatic improvement. At the 3-month follow-up, his wounds had been completely remitted. Discussion: Nonuremic calciphylaxis occurs in many cases, like vitamin D administration, vitamin K antagonists’ administration, chronic inflammation, and others. The association between calciphylaxis and psoriasis was reported only in four cases in the literature; meanwhile, this was the first case that described calciphylaxis in the setting of psoriatic arthritis. Conclusion: A suspicion of calciphylaxis should be maintained in patients with underlying inflammatory mechanism diseases.

show abstract

Warfarin

2022

Reactions Weekly

View full text Add to dashboard Cite

Calciphylaxis: Risk Factors and Histologic Findings in a Case Series From a Tertiary Care Referral Hospital

Cited by 3 publications

References 17 publications

Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease

Calciphylaxis: A Rare Complication With a Fatal Outcome in End-Stage Renal Disease

Calciphylaxis during the course of psoriatic arthritis patient. Is it coincidence? A case report

Warfarin

Contact Info

Product

Resources

About