Calcifying pseudoneoplasm of the CNS

Abstract

Calcifying pseudoneoplasm or fibro-osseous lesion of the CNS is uncommon. We report a case in a 6-year-old boy who presented with generalized tonic-clonic seizures for 6 months. There was a calcified mass in the depth of the left temporal lobe, which on histology showed collagenous nodules surrounded by spindle cells and seperated by chondromyxoid matrix. The only other report of such a lesion in a child is of a 12-year-old boy with an epidural lesion at C-6 level. It is important to recognize this entity since it is slow growing with a good prognosis.

Calcifying Pseudoneoplasms of the Neuraxis: CT, MR Imaging, and Histologic Features

“…[2][3][4][5][6][7][8]10 Most reported lesions have been extra-axial, but several intra-axial cases have also been reported. 1,2 The lesions seem to be slow growing with presenting symptoms related to local compression or irritation of adjacent tissues.…”

“…Since the original pathologic description by Rhodes and Davis, 1 there have been approximately 32 reported cases. [2][3][4][5][6][7][8][9] We found 32 additional cases reported in the literature: 11 spine CAPNON and 21 intracranial CAPNON. Of the intracranial lesions, most were extra-axial and were located at the skull base.…”

Occipital calcified pseudoneoplasms of the neuraxis (CAPNON): understanding a rare pathology

“…Immunohistochemical analysis can aid in the diagnosis of CAPNON with EMA negativity and GFAP positivity 6 20 21. To the best of our knowledge, we are reporting the second CAPNON case that stained positive for GFAP 2 5.…”

Endoscopic resection of calcifying pseudoneoplasm of the neuraxis (CAPNON) of the anterior skull base with sinonasal extension

“…CAPNON arises as a result of local compression and/or irritation of adjacent tissues. 4 CAPNON is a slow-growing, non-neoplastic lesion with no propensity for metastasis. As in our patient, CAPNON can be destructive as it enlarges.…”