Calcifying Pseudoneoplasms of the Neuraxis: CT, MR Imaging, and Histologic Features

Aiken, Ashley H.; Akgün, Hakan; Tihan, Tarık; Barbaro, Nicholas M.; Glastonbury, Christine M.

doi:10.3174/ajnr.a1505

Cited by 86 publications

(140 citation statements)

References 10 publications

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“…18 When considering the differential diagnosis for osteomas, a distinctive feature on MRI is the lesions' lack of enhancement and uniform T1 and T2 signal hypointensity. 1,19,20 The primary differential considerations for osteomas at the skull base are meningiomas (which usually enhance), chordomas (which are usually bright on T2-weighted images), and schwannomas (which are usually bright on T2-weighted images with heterogeneous enhancement). In a more historical context, skull radiographs have been instrumental in identifying osteomas, which in various projections may help identify the location.…”

Section: Discussionmentioning

confidence: 99%

Multiple osteomas of the falx cerebri and anterior skull base: case report

Krisht

Palmer

Couldwell

2016

JNS

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The authors describe a rare case of intracranial extraaxial parafalcine and anterior skull base osteomas in a 22-year-old woman presenting with bifrontal headaches. This case highlights the possible occurrence of such lesions along the anterior skull base and parafalcine region that, as such, should be considered as part of the differential diagnosis for extraaxial calcific lesions involving the anterior skull base. To the authors’ knowledge, this is the first reported case of a patient who underwent complete successful resection of multiple extraaxial osteomas of the anterior skull base and parafalcine region.

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Section: Discussionmentioning

confidence: 99%

Multiple osteomas of the falx cerebri and anterior skull base: case report

Krisht

Palmer

Couldwell

2016

JNS

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“…The classic histopathological features of CAPNON include a set of common elements: 1) presence of chondromyxoid matrix in a nodular pattern; 2) palisading spindle to epithelioid cells; 3) fibroblastic proliferation; 4) amorphous calcification, psammoma bodies and osseous metaplasia; 5) foreign-body reaction with giant cells surrounding the calcified region (1,3,7). These pathological presentations are not evident in each case and some lesions may not show all of the above features (3).…”

Section: Discussionmentioning

confidence: 99%

“…CAPNONs can occur anywhere within the neuraxis, intracranial or spinal, intra-axial or extra-axial (1)(2)(3). Although typically benign, symptoms of CAPNONs typically present secondary to compression and surrounding mass effect (4).…”

Section: Introductionmentioning

confidence: 99%

A case report of calcifying pseudoneoplasm of the neuraxis: an incidental finding after a car accident

Zerehpoosh¹,

Samadian²,

Azhari³

et al. 2016

TJPATH

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Calcifying pseudoneoplasms of the neuraxis are rare, poorly understood lesions that can occur anywhere in the central nervous system without any age or sex predilection. Their pathogenesis is still controversial. Patients can present with various symptoms due to lesion location and only few cases have been discovered incidentally. We present a 25-year-old male referred to our hospital after a car accident. Computed tomography scan and magnetic resonance imaging was done because of the patient's head trauma and a calcified intracranial lesion was found and excised surgically. Pathologic evaluation of the specimen was consistent with the diagnosis of calcifying pseudoneoplasm of the neuraxis.

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“…1 Since that time, a few dozen patients have been reported. 2,3 This fibro-osseous lesion has no particular predilection for site of presentation and can present in either an intraaxial or extra-axial location within the central nervous system. CAPNON arises as a result of local compression and/or irritation of adjacent tissues.…”

Section: Discussionmentioning

confidence: 99%