Calcification Inside Artificial Hearts: Inhibition by Warfarin-Sodium

Pierce, William S.; Donachy, James H.; Rosenberg, Gerson; Baier, Robert E.

doi:10.1126/science.7367883

Cited by 56 publications

(12 citation statements)

References 11 publications

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“…The biomineral deposition is a very important complication that is quite often overlooked in spite of the fact that it takes place in both blood vessels (1) and heart tissues (2). Cardiovascular bioprostheses, when used for a prolonged time, also host calcific deposits that may severely limit the longevity and performance of the bioprostheses (3)(4)(5)(6).…”

Section: Physicochemical Principles Of Cardiovascular Calcificationmentioning

confidence: 99%

Physicochemical principles of cardiovascular calcification

Bb¹

2001

Zeitschrift f�r Kardiologie

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Section: Physicochemical Principles Of Cardiovascular Calcificationmentioning

confidence: 99%

Physicochemical principles of cardiovascular calcification

Bb¹

2001

Zeitschrift f�r Kardiologie

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“…These groups can be provided by direct alloying or admixture of polydimethylsiloxane (PDMS) in the original polymer blend [30]. All blood-contacting surfaces are preferably fabricated to be smooth and free of entrapped air prior to their first exposure to blood.…”

Section: Blood-contacting Materialsmentioning

confidence: 99%

Correlations of Materials Surface Properties with Biological Responses

Baier¹

2015

JSEMAT

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More than 50 years have passed since it was first recognized that the surface properties, and predominantly the surface energies of materials controlled their interactions with all biological phases via their spontaneous acquisition of proteinaceous "conditioning films" of differing degrees of denaturation but usually of the same substances within any given system. This led to the understanding that useful engineering control of such interactions could thus be manifested through adjustments to those surface properties, giving significant control and utility to the biomaterials developer without requiring detailed discovery of the biological specifications of the components involved. Thus, effective selection of adhesive versus abhesive (non-stick, non-retention) outcomes for such useful appliances as dental implants versus substitute blood vessels, or water-resistant bonded structures versus clean, nontoxic ship bottoms is now facilitated with little biological background required. A historical overview is presented, followed by a brief survey of the forces involved and most useful analyses applied. Utility for blood-contacting materials is described in contrast to utility for bone-and tissue-contacting materials, demonstrating practical uses in controlling cell-surface interactions and preventing biofouling. New research directions being explored are noted, urging applications of this prior knowledge to replace the use of toxicants.

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“…This complication has been observed in calves living longer than 3 months and, in our experience, has generally been observed in animals not treated with warfarin sodium [2]. Material limitations, in the form of calcification (calcium phosphate deposition) on the blood contacting elastomeric pump bladder, may result in material perforation with termination of the experiment.…”

Section: Invited Commentarymentioning

confidence: 56%

“…Material limitations, in the form of calcification (calcium phosphate deposition) on the blood contacting elastomeric pump bladder, may result in material perforation with termination of the experiment. Potential solutions to this problem include use of an adult animal model, administration of warfarin sodium [2], or use of drugs to prevent crystal formation such as the diphosphonates [4]. Calcification may be peculiar to growing animals; xenograft valves calcify in children at a significantly faster rate than in adults [3].…”

Section: Invited Commentarymentioning

confidence: 99%