SummarySegmented polyurethane does not induce acute toxicity when subjected to intracutaneous and intravascular tests with mice and rabbits. Specimens, which have been implanted in dogs for 18 months, exhibit stability heretofore unattributed to the general class of polyurethanes. Data on tensile properties, abrasion resistance when wet, tolerance to autoclaving, results of acute toxicity tests, and stability of long-term implants are described along with appropriate means of processing the polymer into useful biomedial devices.
Intracavitary calcium phosphate deposits were observed in smooth, elastomeric blood pump sacs implanted in male calves for periods of 115 to 166 days. These deposits occurred predominantly on the flexing surface of the sacs. In contrast, similar pump sacs remained generally free of mineral deposits for up to 150 days in calves treated with the anticoagulant warfarin-sodium. These results implicate a vitamin K-dependent process in calcium phosphate deposition on elastomeric sacs.
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