CagA seropositivity and the severity of Helicobacter pylori infection in dyspeptic children

Abstract

cagA testing may be of useful clinical interest because its positivity can imply a more severe gastritis and a lower susceptibility to eradication treatment.

The humoral immuneresponse toHelicobacter pyloriinfection in children with gastrointestinal symptoms

“…The majority of our H. pylori ‐seropositive DU (12/18) and gastritis patients (32/48) were infected with CagA positive H. pylori strain. An association between CagA+ H. pylori strains and the presence of gastritis and gastric or duodenal ulcer was previously reported [26–30], as well as inconsistent results [31–33]. Kato et al [31] found that a high prevalence of CagA+ H. pylori strains in children was not associated with peptic ulcer disease.…”

Meta‐analysis: Helicobacter pylori eradication treatment efficacy in children

“…The computerized and manual search revealed 112 studies, of which 80 studies met the established inclusion criteria with 26 treatment regimens, 127 treatment arms and 4436 children 16–95 . The remaining 32 studies (29%) were not included for the following reasons: eradication proportions for children were not reported by treatment arm in 12 (11%) studies, inconsistent treatment protocol or varied treatment regimen in four (5%), inadequate information was given in eight (7%), three studies reported clearance instead of eradication, three studies inadequately assessed H. pylori eradication and two studies included both adults and children.…”

Associations Between Helicobacter pylori Infection, Co‐Morbid Infections, Gastrointestinal Symptoms, and Circulating Cytokines in African Children

“…Helicobacter pylori symptom profiles in children reflect an interplay between the chronicity of infection, the host's immune response [15,39,40], heterogeneity of bacterial virulence [25,26,41,42], and the ability of a child to report and describe symptoms. In addition, psychological symptoms, unfamiliarity with foods and language may contribute to and ⁄ or alter patterns of…”

“…Variations in both microbial virulence and immunologic responses are suggested to account for the spectrum of symptoms described in H. pylori infection [25–28]. Studies of gastric and duodenal mucosal biopsies demonstrate adults predominantly mount a T‐helper 1 (Th1)‐skewed immune responses to H. pylori infection [25], which is less pronounced in children [27,29,30], in whom Th1 responses are generally less mature.…”