Meta‐analysis: Helicobacter pylori eradication treatment efficacy in children

Abstract

SUMMARY BackgroundSeveral meta-analyses assessing the efficacy of anti-Helicobacter pylori treatment in adults have been published but a comparable meta-analysis in children is lacking.

Furazolidone, tetracycline and omeprazole: a low-cost alternative for <i>Helicobacter pylori</i> eradication in children

“…Não há estudos comparativos em relação a custo-efetividade do tratamento do H. pylori porque os estudos são geralmente ensaios de tratamento único com tamanho amostral baixo 12 . Por outro lado, ensaios controlados com placebo não são necessários para testar regimes medicamentosos, pois a erradicação espontâ-nea da infecção não é comum 13 .…”

Furazolidona, tetraciclina e omeprazol: uma alternativa de baixo custo para erradicação de Helicobacter pylori em crianças

“…Continuous variables were expressed by calculation of mean and standard deviation. H. pylori eradication rates are displayed in Table 1 or normal gastric histology (12).…”

“…It lacks comparative studies concerning the cost effectiveness of the H. pylori treatment because the studies are generally single-treatment trials with a small sample. 12 On the other hand, placebo-controlled trials are not needed to test drug regimens because the spontaneous eradication of the infection is unusual. 13 The present study was not designed as a comparative study because this regimen has never been tested in children, and it should be needed to establish the feasibility of this treatment in children.…”

“…26 Side effect rates up to 34% have been reported in eradication therapy in children. 12 Previous studies with tetracycline-based regimens with adults have reported rates ranging from 34 to 59.7%, most of them mild, and the most frequent reported side effects is nausea (up to 34.6%). 18,19,27 It is interesting that the main side effect reported in the present study is abdominal pain, and it is likely that this symptom was related to the clinical condition of the patient rather than to the therapy.…”

Helicobacter pylori—Associated Dyspepsia in Paediatrics

“…Few randomized, placebo-controlled treatment trials are available in children for the different outcomes (gastritis or peptic ulcer), and often consist of only small numbers of cases [86,106]. Clearly in children as in adults, successful eradication of H. pylori markedly reduces the risk of ulcer recurrence [107][108][109][110].…”