CagA antigen of helicobacter pylori and coronary instability: Insight from a clinico-pathological study and a meta-analysis of 4241 cases

Franceschi, Francesco; Niccoli, Giampaolo; Ferrante, Giuseppe; Gasbarrini, Antonio; Baldi, Alfonso; Candelli, Marcello; Feroce, Florinda; Saulnier, N.; Conte, Micaela; Roccarina, Davide; Lanza, Gaetano Antonio; Gasbarrini, Giovanni; Gentiloni, Silveri Nicolò; Crea, Filippo

doi:10.1016/j.atherosclerosis.2008.04.051

Cited by 90 publications

(77 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Helicobacter pylori, Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenza are some of these organisms. The association between H. pylori infection and coronary artery disease was described by Mendel et al in 1994 and has further been tested by several studies 4,5,6,7,8,9,10 . Our study was conducted because of the conflicting results available from the study results published from different parts of world and also because the lack of studies in India till now testing the effect of H. pylori seropositivity on the prognosis of the patients with unstable angina.…”

Section: Discussionmentioning

confidence: 92%

Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

Kaulgud

Kamath

2013

Int Jour of Biomed Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

Kaulgud

Kamath

2013

Int Jour of Biomed Res

View full text Add to dashboard Cite

“…Secondly, we did not have data on CagA status, which is an important virulence factor for H. pylori. This is relevant because previous studies involving populations of European ancestry have suggested a positive association among individuals with CagApositive-H. pylori strains and atherosclerosis 7,27) . However, we believe that this issue may not be a concern because the majority of H. pylori strains were CagApositive in East Asian populations, including those of Japan 28) .…”

Section: Resultsmentioning

confidence: 99%

“…The majority of previous research on the above association was conducted in Western countries [5][6][7][8][9][10][11][12][13] and findings have been inconsistent and inconclusive. It is possible, however, that variations in the study tion to H. pylori seropositivity.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the findings from several prospective studies involving a large sample size showed no or only modest association between H. pylori infection and overall CVD mortality [11][12][13] . Although a review of evidence till date does not support the major role of H. pylori in the development of CVD, it is possible that H. pylori, especially specific CagA positive H. pylori strains, is associated with the risk of certain subtypes of stroke or CHD 7) . A prospective analysis of data from the National Health and Nutrition Examination Survey III showed an inverse association between H. pylori and stroke mortality, with a hazard ratio of 0.69 (0.44 -1.08) for individuals infected with H. pylori 13) .…”

Section: Discussionmentioning

confidence: 99%

“…The positive association of H. pylori infection with CVD was first reported in a case-control study 4) in which individuals with H. pylori seropositivity had an increased risk, approximately two-fold, of developing CVD. However, not all subsequent studies have supported these results [5][6][7][8][9][10][11][12][13] . For example, a 1998 meta-analysis of 18 studies found no significant association between H. pylori and risk of coronary heart disease (CHD), a major component of CVD 14) .…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Lin

Obata

Kikuchi

et al. 2015

JAT

View full text Add to dashboard Cite

Aim: An increasing number of studies have linked Helicobacter pylori (H. pylori) infection to extragastric diseases; however, the role of H. pylori in the pathogenesis of cardiovascular disease (CVD) remains controversial. We examined the association between H. pylori infection and risk of death from coronary heart disease (CHD) and stroke in a nested case-control study within a large prospective cohort study of Japanese subjects. Methods: The cases were 627 subjects who died from CHD and stroke during the follow-up period until December 31, 2003, and 627 control subjects were selected and matched to cases on sex, age, and area. Commercial immunoassay IgG enzyme-linked immunosorbent assay kits were used for the determination of the seropositivity for H. pylori. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using a conditional logistic regression model. Conclusion:The results of this nested case-control study suggest that there is no association between H. pylori infection and CHD and stroke mortality risk in otherwise healthy, elderly Japanese individuals.

show abstract

Serum hsCRP and procalcitonin levels in dyspeptic patients infected with CagA‐positive Helicobacter pylori

Bulur

Ozgur

Küçükazman

et al. 2014

Clinical Laboratory Analysis

View full text Add to dashboard Cite

Helicobacter pylori (HP) is a Gram-negative bacteria that infects approximately half of the world's population (1). These bacteria colonize the mucosa of the stomach antrum and cause chronic gastritis. Although the prevalence of this infection is high, most individuals remain asymptomatic. Factors that cause HP-associated disease are called virulence factors. CagA is one of the important virulence factors that trigger inflammation. CagA is associated with peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma (2).Coronary heart disease, iron-deficiency anemia, pernicious anemia, and idiopathic thrombocytopenic purpura have been linked to HP infection (3). These extragastric manifestations of HP infection are thought that they are derived from HP-triggered systemic inflammation.C-reactive protein (CRP) is an acute phase reactant that is sensitive to systemic inflammation. Because of its sensitivity, it is used as a clinical marker of infection and tissue damage. CRP is not only specific for infection, serum CRP levels usually increase to high levels after infections, myocardial infarction, stress, trauma, neoplastic proliferation, and surgery (4, 5). High-sensitivity CRP (hsCRP) assays allow measuring very low levels of circulating CRP. Levels of hsCRP are affected by diverse states other than systemic infection, including body mass index, alcohol, and tobacco consumption, and diseases such as diabetes mellitus and coronary heart disease (6). In the past few decades, hsCRP has emerged as a predictor of coronary heart disease (7).Procalcitonin (PCT) is a polypeptide precursor of calcitonin that is produced by thyroid gland (8). In the early 1990s, it was observed that PCT levels increase after bacterial infections. Because PCT does not increase during neoplastic and autoimmune processes, or viral infections, it is used as a marker for sepsis and severe bacterial and fungal infections (9). PCT levels are increased independently from calcitonin in bacterial infections. Its major production sites are not exactly known but, it has became apparent that hepatocytes, neutrophils, and mononuclear cells can produce PCT (10).CagA is an important virulence factor for HP infection. We hypothesized that CagA-positive HP infection would cause more serious systemic responses vs. CagA-negative HP infection. Thus we investigated the effect of CagA positivity to serum levels of CRP and PCT in patients with HP infection.

show abstract

CagA antigen of helicobacter pylori and coronary instability: Insight from a clinico-pathological study and a meta-analysis of 4241 cases

Cited by 90 publications

References 35 publications

Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

Early prognosis of unstable angina patients with positive Helicobacter pylori IgG values

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

Serum hsCRP and procalcitonin levels in dyspeptic patients infected with CagA‐positive Helicobacter pylori

Contact Info

Product

Resources

About