Background/aim: Renal function of patients with hypothyroidism increases after reaching euthyroid state. There is no data regarding geriatric age group. The aim of the study was determined to investigate whether renal function of geriatric patients with hypothyroidism increases after they become euthyroid. Materials and methods:Patients who were sixty-five years or older were retrospectively screened in two centers. TSH, T3, T4, creatinine, and eGFR calculated by CKD-EPI formula were recorded under the presence of accompanying hypothyroidism. The same variables were recorded after the patients became euthyroid.Results: 285 patients were included in the study, the median age was 73(65-84), and 234 patients were female. Patients were examined in four groups according to TSH values. There were 160 (56.1%) patients with TSH 5-9.9 uIU/mL, 60(21.1%) patients with TSH between 10-19.9 uIU/mL, 41(14.4 %) patients with TSH between 20-49.9 uIU/mL and 24(8.4%) patients with TSH> 50uIU/mL. There was a significant and negative correlation between the initial TSH values and the first calculated eGFR values (p: 0.001; r: -0.191). The median eGFR of the patients in hypothyroid cases was 66.59 (14.62-116.07), while the median eGFR value of patients was 69.6 (12.91-109.31) in the euthyroid state. This value obtained after thyroid replacement was significantly improved when compared to the first eGFR (p: 0.001). In logistic regression analysis, pretreatment TSH value was found to independently affect eGFR (p: 0.009; Exb: 1.017). Conclusion:It has been observed that hypothyroidism treatment increases eGFR in geriatric patients. Similar results were obtained after studies with younger patients in the literature. This study is a study in which only geriatric age group patients were examined. It should be kept in mind that hypothyroidism which is not corrected in geriatric patients may also contribute to a decrease in eGFR.
Objectives Obesity and related diseases have become one of the most important health problems in the modern age. In addition to its clinical use in the treatment of obesity, bariatric surgery reduces obesity-induced inflammation. Neutrophil–lymphocyte ratio (NLR) is a cheap and easily attainable inflammatory marker. The purpose of this study is to show the effect of bariatric surgery on NLR at preoperative and postoperative 3rd, 6th, and 12th months after SG. Methods 298 patients, who underwent sleeve gastrectomy (SG) in general surgery clinic between 2015 and 2017, were included in the study. We excluded the patients younger than 18 years old, and did not have any inflammatory, infectious, hematological, and comorbide diseases such as diabetes mellitus, cardiovascular diseases, ischemic heart disease, hypertension, renal insufficiency, cancer, and respiratory problems like asthma, obstructive sleep apnea syndrome. We evaluated the levels of NLR at preoperative and postoperative 3rd, 6th, and 12th months visits. Results There were a total of 298 adult patients (age: mean 38.6, minimum 18, maximum 69 years old). Of whom 247 were female (82.9%) and 51 were male (17.1%). We found that NLR levels decreased significantly at 3rd, 6th, and 12th month visits after SG (p<0.001). Conclusions We concluded that NLR levels decrease after surgery in a proportional reduction in adipose tissue. The decrease in NLR levels may also be associated with the protective effects of sleeve gastrectomy against low-grade inflammation-related diseases.
Helicobacter pylori (HP) is a Gram-negative bacteria that infects approximately half of the world's population (1). These bacteria colonize the mucosa of the stomach antrum and cause chronic gastritis. Although the prevalence of this infection is high, most individuals remain asymptomatic. Factors that cause HP-associated disease are called virulence factors. CagA is one of the important virulence factors that trigger inflammation. CagA is associated with peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue (MALT) lymphoma (2).Coronary heart disease, iron-deficiency anemia, pernicious anemia, and idiopathic thrombocytopenic purpura have been linked to HP infection (3). These extragastric manifestations of HP infection are thought that they are derived from HP-triggered systemic inflammation.C-reactive protein (CRP) is an acute phase reactant that is sensitive to systemic inflammation. Because of its sensitivity, it is used as a clinical marker of infection and tissue damage. CRP is not only specific for infection, serum CRP levels usually increase to high levels after infections, myocardial infarction, stress, trauma, neoplastic proliferation, and surgery (4, 5). High-sensitivity CRP (hsCRP) assays allow measuring very low levels of circulating CRP. Levels of hsCRP are affected by diverse states other than systemic infection, including body mass index, alcohol, and tobacco consumption, and diseases such as diabetes mellitus and coronary heart disease (6). In the past few decades, hsCRP has emerged as a predictor of coronary heart disease (7).Procalcitonin (PCT) is a polypeptide precursor of calcitonin that is produced by thyroid gland (8). In the early 1990s, it was observed that PCT levels increase after bacterial infections. Because PCT does not increase during neoplastic and autoimmune processes, or viral infections, it is used as a marker for sepsis and severe bacterial and fungal infections (9). PCT levels are increased independently from calcitonin in bacterial infections. Its major production sites are not exactly known but, it has became apparent that hepatocytes, neutrophils, and mononuclear cells can produce PCT (10).CagA is an important virulence factor for HP infection. We hypothesized that CagA-positive HP infection would cause more serious systemic responses vs. CagA-negative HP infection. Thus we investigated the effect of CagA positivity to serum levels of CRP and PCT in patients with HP infection.
This HRR was calculated for the first(HRR1) , and the second minutes of recovery phase(HRR2). Results: According to basic clinical and demographic characteristics, groups were similar with regard to age and gender. No significant differences were observed in the initial systolic blood pressures or maximal systolic blood pressures or resting heart rates between three groups. All patients and control group participants had sinus rhythm and normal 12 lead ECG results at rest. The maximal heart rate and baseline heart rate during exercise stress test were similar in UC, CD and control groups . The first and the second minute HRR indices of patients with UC and CD were similar to those of the control group. ConClusions: The HRR index, which is calculated by an exercise stress test and associated with autonomic nervous system function, is not affected in UC and CD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.