Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio

Bulur, Oktay; Öztürk, Doğan; Ertuğrul, Derun Taner; Sayın, Selim; Asiltürk, Zeliha; Dal, Kürşat; Şahin, Mustafa; Buluş, Hakan; Uzman, Metin

doi:10.1515/jbcpp-2020-0179

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…In the current study, a high proportion of patients were found with elevated NLR (44.4%) and CRP (75%) before surgery, which was consistent with an underlying inflammatory process ( 4 ). Similar to the findings of Bulur O et al and Randell EW et al, we also found that the levels of NLR and CRP significantly reduced after LSG surgery ( 6 , 18 ). As non-specific inflammatory markers, those reductions indicated the improvement of systemic inflammatory response.…”

Section: Discussionsupporting

confidence: 91%

Might female patients benefit more from bariatric surgery with respect to inflammation

et al. 2022

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BackgroundBariatric surgery is an effective method for severe obesity and its related comorbidities, in which inflammation plays a crucial role. The aim of this study was to investigate the changes of Neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) in patients undergoing laparoscopic sleeve gastrectomy (LSG) and to explore the related factors including gender.MethodsWe retrospectively included 72 patients undergoing LSG in our hospital from 2017 to 2020. Clinical information, laboratory investigations as well as parameters derived from traditional and 2D strain echocardiography were collected. Univariate logistic model was used in myocardial performance index (MPI) and E/E′ analysis. Univariate and Multivariate logistic model were used in NLR analysis.ResultsAt baseline, all patients had normal left ventricular ejection fraction (LVEF). The myocardial performance index (MPI) (OR = 1.218 (95%CI 1.040, 1.426); p = 0.0142) and E/E′ (OR = 1.364 (95%CI 1.124, 1.655); p = 0.0017) were independently associated with CRP. LSG led to a significant decrease in inflammatory markers (NLR, 2.4 ± 1.59 vs.1.7 ± 0.86; CRP, 5.6 ± 3.17 vs. 2.1 ± 2.35 mg/L, respectively, both p < 0.001),which was more in NLR among female than male (OR = 3.14 (95%CI 1.112, 8.870); p = 0.031).ConclusionsThe present study indicated a significant correlation between subclinical cardiac dysfunction and CRP among obese patients. Furthermore, female patients might benefit more from bariatric surgery on inflammation.

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Section: Discussionsupporting

confidence: 91%

Might female patients benefit more from bariatric surgery with respect to inflammation

et al. 2022

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“…The NLR has been studied several times following bariatric surgery [ 9 , 13 , 14 ]. Bulur et al [ 27 ] showed that the NLR decreased after surgery in a proportional reduction in adipose tissue. Da Silva et al [ 13 ] demonstrated that postoperative day 1 NLR was independently associated with 30-day outcomes following bariatric surgery.…”

Section: Discussionmentioning

confidence: 99%

Does Neutrophil-Lymphocyte Ratio Correlate with the Improvement of Hepatosteatosis after Laparoscopic Sleeve Gastrectomy?

Yıldırım¹,

Karabıçak²,

Ulu

et al. 2022

Obes Facts

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Introduction: Obesity is a disease that shortens life expectancy and predisposes to many diseases such as severe hepatosteatosis. Hepatosteatosis is characterized by inflammatory infiltration of the portal space. Bariatric surgery has improvement effect on hepatosteatosis and degree of inflammation. Laparoscopic sleeve gastrectomy is an effective and most common therapeutic option for obesity. Neutrophil-lymphocyte ratio is a parameter associated with inflammatory disease. This study aimed to investigate if there is any correlation between improvements in hepatosteatosis and biochemical parameters especially Neutrophil-lymphocyte ratio and ultrasonographic findings one year after the laparoscopic sleeve gastrectomy. Methods: The files of 66 patients who underwent laparoscopic sleeve gastrectomy between May 2017 and April 2020 were retrospectively reviewed. Preoperative and postoperative one year demographic data, biochemical and inflammatory parameters and ultrasonographic reports of the liver were reviewed. Results: A statistically significant improvement in hepatosteatosis was demonstrated by ultrasonography one year after laparoscopic sleeve gastrectomy. A significant decrease was also observed in Neutrophil-lymphocyte ratio. No correlation was found between the decrease of Neutrophil-lymphocyte ratio and improvement in hepatosteatosis. There was also significant difference between the preoperative and postoperative BMI, biochemical and inflammatory parameters. Conclusion: However we found laparoscopic sleeve gastrectomy is associated with significant improvement in hepatosteatosis and inflammatory parameters, no correlation between the improvement in hepatosteatosis and NLR was seen at one-year.

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Renal Function Following Bariatric Surgery: a Literature Review of Potential Mechanisms

Chen

Xiong

et al. 2022

OBES SURG

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Effects of sleeve gastrectomy on neutrophil–lymphocyte ratio

Cited by 3 publications

References 33 publications

Might female patients benefit more from bariatric surgery with respect to inflammation

Might female patients benefit more from bariatric surgery with respect to inflammation

Does Neutrophil-Lymphocyte Ratio Correlate with the Improvement of Hepatosteatosis after Laparoscopic Sleeve Gastrectomy?

Renal Function Following Bariatric Surgery: a Literature Review of Potential Mechanisms

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