Caffeoylquinic Acids Rich versus Poor Fractions of Gynura procumbens: Their Comparative Antihyperlipidemic and Antioxidant Potential

Murugesu, Kisantini; Murugaiyah, Vikneswaran; Saghir, Sultan Ayesh Mohammed; Asmawi, Mohd Zaini; Sadikun, Amirin

doi:10.2174/1389201019666180322111800

Cited by 6 publications

(4 citation statements)

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“…In the case of hyperlipidemia, a typical indicator of the rise of oxidative stress in the heart, it is closely linked to the overproduction of ROS and a damaged antioxidant defense system (34), and the disrupted balance between ROS generation and the ROS scavenging system will result in intracellular formation and accumulation of superoxide ions, leading to dysfunction and cell damage (35). Considering that the elevated ROS levels cause strong injurious effects on hyperlipidemia patients, nowadays, various types of antioxidant agents have been investigated for their potential in the treatment of hyperlipidemia (36).…”

Section: Discussionmentioning

confidence: 99%

Curcumin‑loaded PEG‑PDLLA nanoparticles for attenuating palmitate‑induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway

et al. 2019

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Curcumin (CUR) has the ability to attenuate oxidative stress in the myocardium and to protect the myocardium from lipotoxic injury owing to its lipid-reducing properties. However, the use of CUR is limited due to its hydrophobicity and instability. In this study, CUR-loaded nanoparticles (CUR NPs) were developed using an amphiphilic copolymer, monomethoxy poly (ethylene glycol)-b-poly (DL-lactide), as a vehicle material. CUR NPs with high drug loading and small size were prepared under optimized conditions. The effects of CUR NPs on palmitate-induced cardiomyocyte injury were investigated and the possible protective mechanism of CUR NPs was also examined. It was found that CUR NPs were able to control the release of CUR and to deliver CUR to H9C2 cells, and they could prevent palmitate-treated H9C2 cells from apoptosis. In addition, CUR NPs could regulate the Bax and Bcl-2 levels of palmitate-treated H9C2 cells back to their respective normal levels. A prospective mechanism for the function of CUR NPs is that they may activate the AMP-activated protein kinase (AMPK)/mammalian target of rapamycin complex-1/p-p70 ribosomal protein S6 kinase signaling pathway, regulate the expression of downstream proteins and resist the palmitate-induced cardiomyocyte injury. Results suggest that CUR NPs can attenuate palmitate-induced oxidative stress in cardiomyocytes and protect cardiomyocytes from apoptosis through the AMPK pathway. In view of the safety and efficiency of these CUR NPs, they have potential for application in protecting the myocardium from lipotoxic injury.

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Section: Discussionmentioning

confidence: 99%

Curcumin‑loaded PEG‑PDLLA nanoparticles for attenuating palmitate‑induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway

et al. 2019

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“…Therefore, fraction that rich caffeoylquinic has potential for development into phytopharmaceuticals as adjunct therapy for management of hyperlipidaemia. 8…”

Section: Caffeoylquinic Acidsmentioning

confidence: 99%

“…The di-caffeoylquinic acids are responsible for the potent antihyperlipidaemia effect. 8…”

Section: Anti-hyperlipidaemia Effectsmentioning

confidence: 99%

Overview of Herbal Therapy with Leave of Gynura procumbens (Lour.) Merr

Timotius¹,

Rahayu²

2020

JYP

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Plants are important source of traditional medicine that can be used to aid many type of illness. Gynura procumbens is one of the plants that are often used by Indonesian people as traditional medicine. Gynura procumbens exhibits antibacterial, anticancer, anti-hyperglycemic, antihypertensive, anti-inflammatory, antioxidant, cardioprotective, fertility enhancement, organ protective activity. This review aims to provide an overview on the relatedness of the identified bioactive compounds with the reported biological activities of Gynura procumbens leave and on the herbal therapy with leave of Gynura procumbens. Literature search is carried out with the help of two searching engines: PubMed and Science Direct. The searching was carried out with keyword: Gynura procumbens. From PubMed and Science Direct, 42 and 94 results were obtained respectively. There were 45 full text articles that meet systematic review criteria. The relevant information is compiled to illustrate that leave of Gynura procumbens is a potential natural source of compounds with various pharmacological actions. Polar, semi and nonpolar solvent can be used to extract the bioactive compounds from the leave of Gynura procumbens. The identified bioactive compounds belong to phenolic, flavonoid, coumaric acids, essential oils, carbohydrates and proteins. Most of the extracts show potent antioxidative activity. The bioactivities of the leave extract are associated with many diseases, such as diabetes, hypertension, cancer, obesity, etc. The herbal therapy with leave of Gynura procumbens can be appropriately applied in oral administration and topical application. Leave of Gynura procumbens is good resource for oral or topical herbal medicine/ingredient.

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“…Merr. 15,16-Dihydroxy-9Z, 12Z-octadecadienoic acid (PubChem CID: 16061068) Akowuah et al (2002) , Rosidah et al (2008) , Kim et al (2011) , Kaewseejan and Siriamornpun (2015) , Murugesu et al (2017) , Li et al (2018) , Murugaiyah et al (2018) , Nazri et al (2019) , Huang et al (2019) , Liu M. et al (2019) , Liu Y. et al (2019) , Chandradevan et al (2020) 3,4-Dicaffeoylquinic acid (Isochlorogenic acid B) (PubChem CID: 5281780) 3,5-Dicaffeoylquinic acid (Isochlorogenic acid A) (PubChem CID: 6474310) 3,5-O-Dicaffeoylquinic acid (PubChem CID: 13604688) 3-O-Methyl gallic acid sulfate (PubChem CID: not found) 3-Carene (PubChem CID: 26049) 4,5-Dicaffeoylquinic acid (Isochlorogenic acids C) (PubChem CID: 6474309) 4-O-Methyl gallic acid sulfate (PubChem CID: not found) 5-O-(E)-Caffeoyl-galactaric acid (PubChem CID: not found) Apigenin (PubChem CID: 5280443) Caffeic acid (PubChem CID: 689043) Chlorogenic acid (PubChem CID: 1794427) Choline (PubChem CID: 305) Citric acid (PubChem CID: 311) Cynarine (PubChem CID: 5281769) Dicaffeoylquinic acids (PubChem CID: 6474310) Eriocitrin (PubChem CID: 83489) Ferulic acid (PubChem CID: 445858) Feruloylquinic acid (PubChem CID: 10133609) Gallic acid (PubChem CID: 370) Genkwanin isomer (PubChem CID: 5281617) Isobioquercetin (PubChem CID: not found) Kaempferol (PubChem CID: 5280863) Kaem...…”

Section: Future Perspectivementioning

confidence: 99%

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

et al. 2020

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Background:Gynura species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding Gynura species that exhibited antioxidant and anti-inflammatory effects, thus providing perspectives and instructions for future research of the plants as a potential source of new dietary supplements or medicinal agents.Methods: A literature search from internet databases of PubMed, Scopus, Science Direct, e-theses Online Service, and ProQuest was carried out using a combination of keywords such as “Gynura,” “antioxidant,” “anti-inflammatory,” or other related words. Research articles were included in this study if they were experimental (in vitro and in vivo) or clinical studies on the antioxidant or anti-inflammatory effects of Gynura species and if they were articles published in English.Results: Altogether, 27 studies on antioxidant and anti-inflammatory effects of Gynura species were selected. The antioxidant effects of Gynura species were manifested by inhibition of reactive oxygen species production and lipid peroxidation, modulation of glutathione-related parameters, and enzymatic antioxidant production or activities. The anti-inflammatory effects of Gynura species were through the modulation of inflammatory cytokine production, inhibition of prostaglandin E2 and nitric oxide production, cellular inflammatory-related parameters, and inflammation in animal models. The potential anti-inflammatory signaling pathways modulated by Gynura species are glycogen synthase kinase-3, nuclear factor erythroid 2-related factor 2, PPARγ, MAPK, NF-κB, and PI3K/Akt. However, most reports on antioxidant and anti-inflammatory effects of the plants were on crude extracts, and the chemical constituents contributing to bioactivities were not clearly understood. There is a variation in quality of studies in terms of design, conduct, and interpretation, and in-depth studies on the underlying mechanisms involved in antioxidant and anti-inflammatory effects of the plants are in demand. Moreover, there is limited clinical study on antioxidant and anti-inflammatory effects of Gynura species.Conclusion: This review highlighted antioxidant and anti-inflammatory effects of genus Gynura and supported their traditional uses to treat oxidative stress and inflammatory-related diseases. This review is expected to catalyze further studies on genus Gynura. However, extensive preclinical data need to be generated from toxicity and pharmacokinetic studies before clinical studies can be pursued for their development into clinical medicines to treat oxidative stress and inflammatory conditions.

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Caffeoylquinic Acids Rich versus Poor Fractions of Gynura procumbens: Their Comparative Antihyperlipidemic and Antioxidant Potential

Abstract: The resin separation technology may find application in caffeoylquinic acids enrichment of plant extracts for pre-clinical studies. The F2 has potential for development into phytopharmaceuticals as adjunct therapy for management of hyperlipidemia.

Cited by 6 publications

References 0 publications

Curcumin‑loaded PEG‑PDLLA nanoparticles for attenuating palmitate‑induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway

Curcumin‑loaded PEG‑PDLLA nanoparticles for attenuating palmitate‑induced oxidative stress and cardiomyocyte apoptosis through AMPK pathway

Overview of Herbal Therapy with Leave of Gynura procumbens (Lour.) Merr

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

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