Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer

Tworoger, Shelley S.; Gertig, Dorota M.; Gates, Margaret A.; Hecht, Jonathan L.; Hankinson, Susan E.

doi:10.1002/cncr.23275

Cited by 96 publications

(101 citation statements)

References 54 publications

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“…19 In a recent large population study, epithelial ovarian cancer did not observe an association with smoking. 20 Present results confirm that to tobacco smoking/chewing may not increase the risk of ovarian cancer. However, this study was only observational study but not a randomized control trial for assessment of tobacco in relation with ovarian cancer.…”

Section: Discussionsupporting

confidence: 83%

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Pradhan¹,

Singh²,

Ravikumar³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Ovarian cancer represents one of the most frequently seen malignancies in women and it is the fifth most common cause of cancer-related death in women. The aim of the study to determine the risk factors leading to ovarian cancer in western part of Odisha, India and show the tumour markers in this population.Methods: This is a prospective observational study included 240 ovarian masses diagnosed at Department of Obstetrics and Gynaecology, V. S. S. Medical College, Burla, Sambalpur over 3 years based on preoperative clinical, biochemical (tumour markers) and imaging study and confirm through post-operative histopathology reports.Results: Surface epithelial tumours (68.33%) followed by germ cell tumours (30.83%) are the most common ovarian tumour. Incidence of ovarian cancer is 73.58% in ≤50 years of age group and more number of cases (16.65%) also found in younger age (≤30 year). Overall number of ovarian cancer cases rising. Bilateral tubal ligation is not a protective factor for ovarian cancer (p value >0.05) and consumption of alcohol and tobacco is not increase risk for ovarian cancer. Most of ovarian tumour commonly present with vague abdominal pain (75.83%) followed by mass per abdomen (55%). Ascites mainly a presentation of malignant tumour seen in 46(63.88%) cases. CA125 is the frequently detected tumour markers and all of the tumour markers were significantly within normal limit.Conclusions: Ovarian neoplasia is one of the most common and lethal malignancy in female reproductive tract. Though it is a disease of older age but now a day more no of cases also seen in younger age group. Since most of the ovarian cancer remain asymptomatic for long period so measure should be taken for early diagnosis for best outcome. So, assessment of each regions statistical information reflecting its own profile may be important for estimation of risk for development of ovarian cancer and so useful for early preventive measure before progress to advance stage where prognosis is worst. So, relationship between the profiles of patients and types of ovarian neoplasms may give an idea about the risk factors of the disease in its region. Additionally, distribution of tumour markers might be considered for the dis-criminating of the benign or malign characters of the ovarian neoplasia.

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Section: Discussionsupporting

confidence: 83%

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Pradhan¹,

Singh²,

Ravikumar³

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…In a recent large population study, epithelial ovarian cancer did not observe an association with smoking [21] Our results confirm that smoking may not increase the risk of ovarian cancer. However, this study was not based on cigarette smoking and did not search the insidence of ovarian cancer in cigarette smoking women.…”

Section: Discussionsupporting

confidence: 74%

Changing Trends in the Incidence of Ovarian Neoplasia and Its Relationship with the Risk Factors: A Report of 311 Cases from North-Eastern Anatolia Region

Demirci

Daloglu

Çalık

et al. 2015

EAJM

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Objective: Ovarian cancer is one of the most common and lethal gynecologic malignancy. In Turkey, the 8 th most commonly seen neoplasm is ovarian cancer. The risk factors of ovarian cancer are menstrual reproductive events including gravida, menarche and menopause status, and life style habits such as cigarette smoking and habitat. In this study we aimed to determine the risk factors leading to ovarian cancer in Turkish women population and show the tumor markers in this population. Materials and Methods:This study included 311 ovarian neoplasia cases diagnosed at the Pathology Department of Ataturk University in Erzurum over last seven years extending from 2005 to 2013. This study is a retrospective analysis basing on the pathology reports and accesible patient files. Serum tumor markers of the patients were retrospectively reported from their records. Conventional stained preparations existing in our archive examined by two pathologists as well independent of each other, and histopathologic diagnosis and the distribution of the sub-group was revised.Results: A total of 311 patients were included in this study in which patients were diagnosed at the Pathology Department of Ataturk University in Erzurum. Serous cystadenoma is the most common ovarian tumor followed by mucinous cystadenoma, germ cell tumors, and dysgerminoma. All of the tumor markers were significantly normal.Conclusion: Upto our knowledge this was the first epidemiological study in Turkey. Analysis of each country's statistical information reflecting its own profile is also important. The relationship between the profiles of patients and types of ovarian neoplasia may give an idea about the risk factors of the disease in its region. Additionally, distribution of tumor markers might be considered for the discriminating of the benign or malign characters of the ovarian neoplasia. Keywords: Ovarian neoplasia, epidemiology, histopathology, tumor markers ÖzetAmaç: Over kanseri, en yaygın ve ölümcül olarak izlenen jinekolojik malignensidir. Türkiye'de kanser sıklık sıralamasında 8. sıradadır. Over kanseri risk faktörleri arasında, gravida, menarş ve menopoz durumu, sigara içme ve yaşam tarzı alışkanlıkları, adet düzeni yer almaktadır. Bu çalışmada, Türk kadın nüfusunun over kanserine yol açan risk faktörlerinin belirlenmesini ve bu populasyondaki tümör belirteçleri göstermeyi amaçladık. Bu çalışmaya, 2005Bu çalışmaya, -2013 yılları arasında Erzurum Atatürk Üniversitesi Patoloji Anabilim Dalı'nda tanılanan 311 over neoplazm olgusu dahil edildi. Patoloji raporları ve erişilebilir hasta dosyaları retrospektif bir analiz ile değerlendirildi. Hastaların serum tümör belirteçleri kendi kayıtlarından alındı. Arşiv preparatları birbirinden bağımsız iki patolog tarafından tekrar değerlendirildi ve histopatolojik tanıların subgruplardaki dağılımı gözden geçirildi. Bulgular: Erzurum Atatürk Üniversitesi Patoloji Anabilim Dalı'nda tanı alan 311 hasta bu çalışmaya dahil edildi. Sıklık sırasına göre, seröz kistadenoma, müsinöz kistadenom, germ hücreli tümörl...

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“…Moreover, insufficient data from 3 relevant may be biased in this meta-analysis. [27][28][29] Thus, these facts may act as confounding factors for comparing EOC risk between wine and never drinkers; Third, we could not evaluate the chemopreventive effect of wine according to dose-dependency because cut-off levels of the increased wine consumption were different among all 7 studies. Fourth, we could not also evaluate EOC risk according to menopausal status and histological types because of the lack of related data, and the results of this meta-analysis should be interpreted considering different covariates for risk estimation.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10][11] However, several epidemiologic results have been heterogenous regarding the association between wine drinking and EOC risk. [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] Therefore, the current study was designed to evaluate the efficacy of wine drinking for reducing EOC risk through a meta-analysis using previous relevant studies.…”

Section: Introductionmentioning

confidence: 99%

Wine drinking and epithelial ovarian cancer risk: a meta-analysis

Kim

Shouten

et al. 2010

J Gynecol Oncol

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Objective: Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies. Methods: After extensive search of the literature between January 1986 and December 2008, we analyzed 10 studies (3 cohort and 7 case control studies) with 135,871 women, who included 65,578 of wine and 70,293 of never drinkers. Results: In all studies, there was no significant difference in EOC risk between wine and never drinkers (odds ratio [OR], 1.13; 95% confidence interval [CI], 0.92 to 1.38; random effects). When we performed re-analysis according to the study design, 3 cohort and 7 case control studies showed that there were also no significant differences in EOC risk between wine and never drinkers, respectively (OR, 1.44 and 1.04; 95% CI, 0.74 and 2.82 and 0.88 to 1.22; random effects). In sub-analyses using 2 case-control studies, EOC risk was not different between former and never drinkers (OR, 1.12; 95% CI, 0.87 to 1.44; fixed effect), and between current and former drinkers (OR, 0.74; 95% CI, 0.41 to 1.34; random effects). Conclusion: Although resveratrol, abundantly found in wine, is a promising naturally occurring compound with chemopreventive properties on EOC in preclinical studies, this meta-analysis suggests the epidemiologic evidence shows no association between wine drinking and EOC risk.

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Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer

Cited by 96 publications

References 54 publications

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Study of risk factors and tumor markers in ovarian malignancy in western part of Odisha: a prospective observational study

Changing Trends in the Incidence of Ovarian Neoplasia and Its Relationship with the Risk Factors: A Report of 311 Cases from North-Eastern Anatolia Region

Wine drinking and epithelial ovarian cancer risk: a meta-analysis

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