Wine drinking and epithelial ovarian cancer risk: a meta-analysis

Abstract

Objective: Wine has been the focus in the prevention of epithelial ovarian cancer (EOC) development because resveratrol abundant in wine has anti-carcinogenic properties. However, epidemiologic results have been heterogenous in the chemopreventive effect of wine on the development of EOC. Thus, we performed a meta-analysis for comparing EOC risk between wine and never drinkers using previous related studies. Methods: After extensive search of the literature between January 1986 and December 2008, we analyzed 10 studies (3 cohort and 7 case control studies) with 135,871 women, who included 65,578 of wine and 70,293 of never drinkers. Results: In all studies, there was no significant difference in EOC risk between wine and never drinkers (odds ratio [OR], 1.13; 95% confidence interval [CI], 0.92 to 1.38; random effects). When we performed re-analysis according to the study design, 3 cohort and 7 case control studies showed that there were also no significant differences in EOC risk between wine and never drinkers, respectively (OR, 1.44 and 1.04; 95% CI, 0.74 and 2.82 and 0.88 to 1.22; random effects). In sub-analyses using 2 case-control studies, EOC risk was not different between former and never drinkers (OR, 1.12; 95% CI, 0.87 to 1.44; fixed effect), and between current and former drinkers (OR, 0.74; 95% CI, 0.41 to 1.34; random effects). Conclusion: Although resveratrol, abundantly found in wine, is a promising naturally occurring compound with chemopreventive properties on EOC in preclinical studies, this meta-analysis suggests the epidemiologic evidence shows no association between wine drinking and EOC risk.

Epidemiology of ovarian cancer: a review

“…A pooled analysis of 10 cohort studies that included over 500,000 women and 2,001 incident OC cases also observed no risk association with total alcohol intake (pooled multivariate RR=1.12, 95% CI: 0.86–1.44 comparing > 30 to 0 g of alcohol per day) or alcohol intake from wine, beer, or spirits 322 . There was no association (OR=1.13, 95% CI: 0.92–1.38) between wine consumption and OC risk in a recent meta-analysis of 10 studies (3 cohort and 7 case-control studies) with 135,871 women, including 65,578 wine drinkers 323 . Based on these data, it seems reasonable to conclude that if alcohol intake does influence risk of OC, the magnitude is small and possibly limited to particular histologic subtypes.…”

Risk Factors for Ovarian Cancer: An Umbrella Review of the Literature

“…We identified 72 eligible publications that included 212 meta-analyses of 1853 individual study estimates exploring associations between non-genetic risk factors and the risk of developing or dying from ovarian cancer ( Figure 1 ) [ 8 , 19 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 …”

Phytochemicals in Gynecological Cancer Prevention

“…A meta-analysis by Kim et al assessed the relationship between wine consumption and ovarian cancer risk. An analysis of 10 studies (three cohort studies and seven clinical control studies) did not show the association between wine consumption and a reduction in the risk of ovarian cancer (OR = 1.13, 95% CI = 0.92–1.38) [ 177 ]. However, the insufficient number of epidemiological studies assessing the effect of resveratrol on the risk of ovarian cancer does not allow to draw clear conclusions.…”